Elucidation of circadian and seasonal variation of thrombosis-related factor in older peoples
Project/Area Number |
23500850
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Applied health science
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Research Institution | Nara Medical University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
INOUE Yoshimitsu 大阪国際大学, 人間科学部, 教授 (70144566)
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | VWF / ADAMTS13 / 季節変動 / 日内変動 / 老化 / VWF抗原量 / VWF活性 / 交感神経系 |
Research Abstract |
VWF revealing a thrombophilic action as a molecular glue and ADAMTS13 revealing an antithrombogenic action by the function of specifically cutting VWF were adopted and circadian variation and seasonal variation thereof and senescent influences modifying them were investigated in platelet thrombosis using healthy older peoples and college boys as subjects. As a result, VWF showed high values for older peoples in all seasons and time zones and a tendency of the highest value in the morning in winter was observed. In contrast, ADAMTS13 showed low values for older peoples and a tendency of the lowest value of activity especially in the morning in winder was observed. These results suggest easier incidence of platelet thrombosis in sporting activity in winder, particularly in the morning, for older peoples.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] ADAMTS13 activity may predict the cumulative survival of patients with liver cirrhosis in comparisonwith the Child-Turcotte-Pugh score and the Model for End-Stage Liver Disease score.2012
Author(s)
Takaya H, Uemura M, Fujimura Y, Matsumoto M,Matsuyama T, Kato S, Morioka C, Ishizashi H,Hori Y, Fujimoto M, Tsujimoto T, Kawaratani H,Toyohara M, Kurumatani N, Fukui H.
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Journal Title
Hepatol Res.
Volume: 42(5)
Pages: 459-72
NAID
Related Report
Peer Reviewed
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[Journal Article] ADAMTS13 activity may predict the cumulative survival of patients with liver cirrhosis in comparison with the Child-Turcotte-Pugh score and the Model for End-Stage Liver Disease score.2012
Author(s)
Takaya H, Uemura M, Fujimura Y, Matsumoto M, Matsuyama T, Kato S, Morioka C, Ishizashi H, Hori Y, Fujimoto M, Tsujimoto T, Kawaratani H, Toyohara M, Kurumatani N, Fukui H.
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Journal Title
Hepatol Res.
Volume: 42(5)
Pages: 459-72
NAID
Related Report
Peer Reviewed
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