The investigations of the effects of fatty acids administration on the functions of aorta
| Project/Area Number |
23500851
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Josai University |
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Principal Investigator |
KASONO KEIZO 城西大学, 薬学部, 教授 (90177387)
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| Co-Investigator(Kenkyū-buntansha) |
NOBE Kouji 城西大学, 薬学部, 准教授 (30276612)
TAKENOUCHI Yasuhiro 城西大学, 薬学部, 助手 (30582233)
角田 伸代 独立行政法人国立長寿医療研究センター, その他部局等, その他 (60337483)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 血管内皮機能 / エイコサペンタエン酸 / 血管収縮反応 / 血管弛緩反応 / 脂肪酸 / ２型糖尿病 / 一酸化窒素 / 糖尿病合併症 / 血管内皮細胞 / n-3系多価不飽和脂肪酸 / EPA / DHA / パルミトオレイン酸 |
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| Research Abstract |
1.Chronic administration of eicosapentaenoic acid ethyl ester (EPA-E) improved Ach-induced relaxation reactivity in the aorta of KKAy diabetic mice. 2.Chronic administration of EPA-E showed no effect on SNP-induced relaxation reactivity in the aorta. 3.Chronic administration of EPA-E showed no effect on the contraction reactivity in the aorta. 4.EPA-E(10microM)did not induce any effect. However, EPA, DPA or DHA(10microM) directly induced remarkable relaxation reaction after the contraction induced by PGF2-alpha.5. In conclusion, EPA-E administration showed the therapeutic effect on the functional disorder of vascular endothelial cells in KKAy diabetic mice.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Unsaturated fatty acids in fish oil play a role in adequate fat distribution to plasma, liver and white adipose tissue2011
Author(s)
Sachiko Shiba, Nobuyo Tsunoda, Kanako Ito, Masaki Wakutsu, Etsuko Muraki, Mariko Sonoda, Phyllis. S. Y. Tam, Yoko Fujiwara, Shinji Ikemoto, Keizo Kasono
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Journal Title
J. Health Sci
Volume: 57(4)
Pages: 341-349
NAID
Related Report
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