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The investigations of the effects of fatty acids administration on the functions of aorta

Research Project

Project/Area Number 23500851
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Applied health science
Research InstitutionJosai University

Principal Investigator

KASONO KEIZO  城西大学, 薬学部, 教授 (90177387)

Co-Investigator(Kenkyū-buntansha) NOBE Kouji  城西大学, 薬学部, 准教授 (30276612)
TAKENOUCHI Yasuhiro  城西大学, 薬学部, 助手 (30582233)
角田 伸代  独立行政法人国立長寿医療研究センター, その他部局等, その他 (60337483)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords血管内皮機能 / エイコサペンタエン酸 / 血管収縮反応 / 血管弛緩反応 / 脂肪酸 / 2型糖尿病 / 一酸化窒素 / 糖尿病合併症 / 血管内皮細胞 / n-3系多価不飽和脂肪酸 / EPA / DHA / パルミトオレイン酸
Research Abstract

1.Chronic administration of eicosapentaenoic acid ethyl ester (EPA-E) improved Ach-induced relaxation reactivity in the aorta of KKAy diabetic mice. 2.Chronic administration of EPA-E showed no effect on SNP-induced relaxation reactivity in the aorta. 3.Chronic administration of EPA-E showed no effect on the contraction reactivity in the aorta. 4.EPA-E(10microM)did not induce any effect. However, EPA, DPA or DHA(10microM) directly induced remarkable relaxation reaction after the contraction induced by PGF2-alpha.5. In conclusion, EPA-E administration showed the therapeutic effect on the functional disorder of vascular endothelial cells in KKAy diabetic mice.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (14 results)

All 2014 2013 2012 2011

All Journal Article (9 results) Presentation (3 results) Book (2 results)

  • [Journal Article] Adiponectin enhances calcium-dependency of mouse bladder contraction mediated by protein kinase Cα expression2013

    • Author(s)
      Koji Nobe, Akiko Fujii, Kiyomi Saito, Takaharu Negoro, Yasuo Ogawa, Yasuko Nakano, Terumasa Hashimoto, Kazuo Honda
    • Journal Title

      J. Pharmacol. Exp. Ther

      Volume: 345 Pages: 62-68

    • Related Report
      2013 Final Research Report
  • [Journal Article] Fenugreek with reduced bitterness prevents diet-induced metabolic disorders in rats2012

    • Author(s)
      Muraki Etsuko, Hiroshige Chiba, Keiko Taketani, Shohei Hoshino, Nobuaki Tsuge, Nobuyo Tsunoda, Keizo Kasono
    • Journal Title

      Lipids Health Dis

      Volume: 11 Pages: 58-58

    • NAID

      120005520710

    • Related Report
      2013 Final Research Report
  • [Journal Article] Improvement in the high-fat diet-induced dyslipidemia and adiponectin levels by fish oil feeding combined with food restriction in obese KKAy mice2012

    • Author(s)
      Masaki Wakutsu, Nobuyo Tsunoda, Yasuki Mochi, Mitsuki Numajiri, Sachiko Shiba, Etsuko Muraki, Keizo Kasono
    • Journal Title

      Biosci. Biotechnol. Biochem

      Volume: 76(5) Pages: 1011-1014

    • NAID

      10030753153

    • Related Report
      2013 Final Research Report
  • [Journal Article] Spatiotemporal dynamics of intracellular calcium in the middle cerebral artery isolated from stroke-prone spontaneously hypertensive rats2012

    • Author(s)
      Terumasa Hashimoto, Mariko Kiya, Hisayuki Ohata, Takuro Miyazaki, Keita Shibata, Koji Nobe and Kazuo Honda
    • Journal Title

      Exp. Physiol

      Volume: 97(2) Pages: 265-276

    • Related Report
      2013 Final Research Report
  • [Journal Article] Two distinct dysfunctions in diabetic mouse mesenteric artery contraction are caused by changes in the Rho A-Rho kinase signaling pathway2012

    • Author(s)
      Koji Nobe, Terumasa Hashimoto and Kazuo Honda
    • Journal Title

      Eur. J. Pharmacol

      Volume: 683(1-3) Pages: 217-225

    • Related Report
      2013 Final Research Report
  • [Journal Article] Dose-dependent effects, safety and tolerability of fenugreek in diet-induced metabolic disorders in rats2011

    • Author(s)
      Etsuko Muraki, Yukie Hayashi, Hiroshige Chiba, Nobuyo Tsunoda, Keizo Kasono
    • Journal Title

      Lipids Health Dis

      Volume: 10 Pages: 240-240

    • NAID

      120005520709

    • Related Report
      2013 Final Research Report
  • [Journal Article] Regulation of lipid metabolism by palmitoleate and eicosapentaenoic acid (EPA) in mice fed a high-fat diet2011

    • Author(s)
      Sachiko Shiba, Nobuyo Tsunoda, Masaki Wakutsu, Etsuko Muraki, Mariko Sonoda, Phyllis S.Y. Tam, Yoko Fujiwara, Shinji Ikemoto, Keizo Kasono
    • Journal Title

      Biosci Biotechnol Biochem

      Volume: 75(12) Pages: 2401-2403

    • NAID

      10030397966

    • Related Report
      2013 Final Research Report
  • [Journal Article] Fenugreek improves diet-induced metabolic disorders in rats2011

    • Author(s)
      Etsuko Muraki, Hiroshige Chiba, Nobuyo Tsunoda, Keizo Kasono
    • Journal Title

      HormMetab Res

      Volume: 43(13) Pages: 950-955

    • Related Report
      2013 Final Research Report
  • [Journal Article] Unsaturated fatty acids in fish oil play a role in adequate fat distribution to plasma, liver and white adipose tissue2011

    • Author(s)
      Sachiko Shiba, Nobuyo Tsunoda, Kanako Ito, Masaki Wakutsu, Etsuko Muraki, Mariko Sonoda, Phyllis. S. Y. Tam, Yoko Fujiwara, Shinji Ikemoto, Keizo Kasono
    • Journal Title

      J. Health Sci

      Volume: 57(4) Pages: 341-349

    • NAID

      120005520790

    • Related Report
      2013 Final Research Report
  • [Presentation] 温泉施設を利用した仲間づくりおよび健康増進プログラムの提供が生活習慣病リスク軽減に及ぼす影響2011

    • Author(s)
      山川裕子, 角田伸代, 村木悦子, 斎藤京子, 加園恵三
    • Organizer
      第58回日本栄養改善学会学術総会
    • Place of Presentation
      広島
    • Related Report
      2013 Final Research Report
  • [Presentation] Fenugreek with Reduced Bitterness Prevents Diet-induced Metabolic Disorders in Rats2011

    • Author(s)
      Etsuko Muraki, Hiroshige Chiba, Shohei Hoshino, Keiko Taketani, Nobuaki Tsuge, Yasuhiro Takenouchi, Nobuyo Tsunoda, keizo Kasono
    • Organizer
      American Diabetes Association's 71st Scientific Sessions
    • Place of Presentation
      San Diego, America
    • Related Report
      2013 Final Research Report
  • [Presentation] Inverse Effects of Fish Oil and Thiazolodonedione Administration on Insulin Sensitivity under Lipoatrophy Induced by Restricted Food Intake2011

    • Author(s)
      Nobuyo Tsunoda, Hiroko Miki, Yasuhiro Takenouchi, Etsuko Muraki, Keizo Kasono
    • Organizer
      American Diabetes Association's 71st Scientific Sessions
    • Place of Presentation
      San Diego, America
    • Related Report
      2013 Final Research Report
  • [Book] 人体の構造と機能および疾病の成り立ち 疾病の成因・病態・診断・治療 第2版 2-疾患治療の概要, 竹中優(編)2014

    • Author(s)
      加園恵三
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2013 Final Research Report
  • [Book] ETERNAL EXPLORER 症例人間病態論2013

    • Author(s)
      加園恵三
    • Publisher
      京都廣川書店
    • Related Report
      2013 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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