| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
1.Chronic administration of eicosapentaenoic acid ethyl ester (EPA-E) improved Ach-induced relaxation reactivity in the aorta of KKAy diabetic mice. 2.Chronic administration of EPA-E showed no effect on SNP-induced relaxation reactivity in the aorta. 3.Chronic administration of EPA-E showed no effect on the contraction reactivity in the aorta. 4.EPA-E(10microM)did not induce any effect. However, EPA, DPA or DHA(10microM) directly induced remarkable relaxation reaction after the contraction induced by PGF2-alpha.5. In conclusion, EPA-E administration showed the therapeutic effect on the functional disorder of vascular endothelial cells in KKAy diabetic mice.
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