Screening and Functional Analyses of the MicroRNAs Involved in Cancer Cell Dormancy
| Project/Area Number |
23501268
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor biology
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| Research Institution | Kobe University |
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Principal Investigator |
SHIMONO YOHEI 神戸大学, 医学(系)研究科(研究院), 准教授 (90594630)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | がん休眠 / 乳がん / マイクロＲＮＡ / ＣＸＣＲ４ / がん幹細胞 / 休眠がん細胞 / マイクロRNA / 細胞表面タンパク質 / 休眠状態がん細胞 |
|---|
| Outline of Final Research Achievements |
Metastatic cancer may emerge more than 10 years after complete remission in human breast cancers. It is considered that these very late relapses are caused by the latent tumor cells that remain dormant in the organs of metastases. In this research, we revealed that the cancer cells in the patient-derived xenografts of human breast cancers are mostly in a G0 phase; the presence of primary cilia is not associated with the cell-cycle arrest; and the downregulation of the chemokine receptor CXCR4 is associated with the cell-cycle arrest. Furthermore, we identified the microRNAs that are preferentially expressed in the cancer cells in the patient-derived xenografts of human breast cancers and revealed a part of the genes and signaling pathways regulated by these microRNAs.
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Report
(5 results)
Research Products
(33 results)
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[Journal Article] Comparison of 2D- and 3D-culture models as drug-testing platforms in breast cancer2015
Author(s)
Imamura Y, Mukohara T, Shimono Y, Funakoshi Y, Chayahara N, Toyoda M, Kiyota N, Takao S, Kono S, Nakatsura T, Minami H
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Journal Title
Oncol Rep
Volume: 33
Issue: 4
Pages: 1837-1843
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] miR-142 regulates the tumorigenicity of human breast cancer stem cells through the canonical WNT signaling pathway2014
Author(s)
Isobe T, Hisamori S, Hogan DJ, Zabala M, Hendrickson DG, Dalerba P, Cai S, Scheeren F, Kuo AH, Sikandar SS, Lam JS, Qian D, Dirbas FM, Somlo G, Lao K, Brown PO, Clarke MF, Shimono Y
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Journal Title
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Absence of primary cilia in cell cycle-arrested human breast cancer cells.2014
Author(s)
Nobutani K, Shimono Y, Yoshida M, Mizutani K, Minami A, Kono S, Mukohara T, Yamasaki T, Itoh T, Takao S, Minami H, Azuma T, Takai Y.
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Journal Title
Genes Cells.
Volume: 19
Issue: 2
Pages: 141-152
DOI
Related Report
Peer Reviewed
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