Cell lineage-related mechanisms involved in lung cancer stem cell development.

• Project/Area Number: 23501281
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Tumor biology
• Research Institution: Aichi Cancer Center Research Institute
• Principal Investigator: OSADA Hirotaka 愛知県がんセンター(研究所), 分子腫瘍学部, 室長 (30204176)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 肺がん / 幹細胞 / がん幹細胞 / 癌幹細胞

Research Abstract

Sphere-forming cells were initially established from several different lung cancer cell lines, after which expression profiling and tumorigenesis assay findings indicated their cancer stem cell properties. In addition, expression of neuroendocrine-related genes in these cells suggests a possible association between sphere formation and cell lineage plasticity. Furthermore, neuroendocrine-inducing ASH1 has also been found to promote sphere formation in some cell lines, suggesting the involvement of ASH1 signaling in development of cancer stem cells.

Research Products

• [Journal Article] CD74-NRG1 fusions in lung adenocarcinoma (2014)
  • Author(s): Fernandez-Cuesta L, Plenker D, Osada H, Sun R, Menon R, Leenders F, Ortiz-Cuaran S, Peifer M, Bos M, DaBler J, Malchers F, Schottle J, Vogel W, Dahmen I, Koker M, Ullrich RT, Wright GM, Russell PA, Wainer Z, Solomon B, Brambilla E, Nagy-Mignotte H, Moro-Sibilot D, Brambilla CG, Lantuejoul S, Altmuller J, Becker C, Nurnberg P, Heuckmann JM, Stoelben E, Petersen I, Clement JH, Sanger J, Muscarella LA, la Torre A, Fazio VM, Lahortiga I, Perera T, Ogata S, Parade M, Brehmer D, Vingron M, Heukamp LC, Buettner R, Zander T, Wolf J, Perner S, Ansen S, Haas SA, Yatabe Y, Thomas RK
  • Journal Title: Cancer Discovery Volume: 4 Pages: 415-422
  • Peer Reviewed
• [Journal Article] RASSF3 downregulation increases malignant phenotypes of non-small cell lung cancer (2014)
  • Author(s): Fukatsu A, Ishiguro F, Tanaka I, Kudo T, Nakagawa K, Shinjo K, Kondo Y, Fujii M, Hasegawa Y, Tomizawa K, Mitsudomi T, Osada H, Hata Y, Sekido Y
  • Journal Title: Lung Cancer Volume: 83 Pages: 23-29
  • Peer Reviewed
• [Journal Article] Hepatitis virus infection affects DNA methylation in mice with humanized livers (2014)
  • Author(s): Okamoto Y, Shinjo K, Shimizu Y, Sano T, Yamao K, Gao W, Fujii M, Osada H, Sekido Y, Murakami S, Tanaka Y, Joh T, Sato S, Takahashi S, Wakita T, Zhu J, Issa JP, Kondo Y
  • Journal Title: Gastroenterology Volume: 146 Pages: 562-572
  • Peer Reviewed
• [Journal Article] LIM-domain protein AJUBA suppresses malignant mesothelioma cell proliferation via Hippo signaling cascad (2014)
  • Author(s): Tanaka I, Osada H, Fujii M, Fukatsu A, Hida T, Horio Y, Kondo Y, Sato A, Hasegawa Y, Tsujimura T, Sekido Y
  • Journal Title: Oncogene Volume: 34 Issue: 1 Pages: 73-83
  • DOI: 10.1038/onc.2013.528
  • Peer Reviewed / Open Access
• [Journal Article] CD74-NRG1 fusions in lung adenocarcinoma (2014)
  • Author(s): Fernandez-Cuesta L1, Plenker D, Osada H, Sun R, Menon R, Leenders F, Ortiz-Cuaran S, Peifer M, Bos M, Dassler J, Malchers F, Schuttle J, Vogel W, Dahmen I, Koker M, Ullrich RT, Wright GM, Russell PA, Wainer Z, Solomon B, 他31名
  • Journal Title: Cancer Discov Volume: 4 Issue: 4 Pages: 415-422
  • DOI: 10.1158/2159-8290.cd-13-0633
  • Peer Reviewed
• [Journal Article] Hepatitis virus infection affects DNA methylation in mice with humanized livers. (2014)
  • Author(s): Okamoto Y, Shinjo K, et al.
  • Journal Title: Gastroenterology Volume: 146 Issue: 2 Pages: 562-572
  • DOI: 10.1053/j.gastro.2013.10.056
  • Peer Reviewed / Open Access
• [Journal Article] Membranous expression of activated leukocyte cell adhesion molecule contributes to poor prognosis and malignant phenotypes of non-small-cell lung cancer (2013)
  • Author(s): Ishiguro F, Murakami H, Mizuno T, Fujii M, Kondo Y, Usami N, Taniguchi T, Yokoi K, Osada H, Sekido Y
  • Journal Title: J Surg Res Volume: 179 Pages: 24-32
  • Peer Reviewed
• [Journal Article] RASSF3 downregulation increases malignant phenotypes of non-small cell lung cancer. (2013)
  • Author(s): Fukatsu A, Ishiguro F, et al.
  • Journal Title: Lung Cancer Volume: 83 Issue: 1 Pages: 23-29
  • DOI: 10.1016/j.lungcan.2013.10.014
  • Peer Reviewed
• [Journal Article] Membranous expression of activated leukocyte cell adhesion molecule contributes to poor prognosis and malignant phenotypes of non-small-cell lung cancer. (2013)
  • Author(s): Futoshi Ishiguro
  • Journal Title: J Surg Res. Volume: 179 Issue: 1 Pages: 24-32
  • DOI: 10.1016/j.jss.2012.08.044
  • Peer Reviewed
• [Journal Article] NKX2-1/TITF1/TTF-1-Induced ROR1 is required to sustain EGFR survival signaling in lung adenocarcinoma (2012)
  • Author(s): Yamaguchi T, Yanagisawa K, Sugiyama R, Hosono Y, Shimada Y, Arima C, Kato S, Tomida S, Suzuki M, Osada H, Takahashi T
  • Journal Title: Cancer Cell Volume: 21 Pages: 348-361
  • Peer Reviewed
• [Journal Article] YAP induces malignant mesothelioma cell proliferation by upregulating transcription of cell cycle promoting genes (2012)
  • Author(s): Mizuno T, Murakami H, Fujii M, Ishiguro F, Tanaka I, Kondo Y, Akatsuka S, Toyokuni S, Yokoi K, Osada H, Sekido Y
  • Journal Title: Oncogene Volume: 31 Pages: 5117-5122
  • Peer Reviewed
• [Journal Article] Activated leukocyte cell adhesion molecule (ALCAM) promotes malignant phenotypes of malignant mesothelioma (2012)
  • Author(s): Ishiguro F, Murakami H, Mizuno T, Fujii M, Kondo Y, Usami N, Yokoi K, Osada H, Sekido Y
  • Journal Title: J Thorac Oncol Volume: 7 Pages: 890-899
  • Peer Reviewed
• [Journal Article] TGF-β synergizes with defects in the Hippo pathway to stimulate human malignant mesothelioma growth (2012)
  • Author(s): Fujii M, Toyoda T, Nakanishi H, Yatabe Y, Sato A, Matsudaira Y, Ito H, Murakami H, Kondo Y, Kondo E, Hida T, Tsujimura T, Osada H, Sekido Y
  • Journal Title: J Exp Med Volume: 209 Pages: 479-494
  • Peer Reviewed
• [Journal Article] Integrated analysis of genetic and epigenetic alterations reveals CpG island methylator phenotype associated with distinct clinical characters of lung adenocarcinoma (2012)
  • Author(s): Shinjo K, Okamoto Y, An B, Yokoyama T, Takeuchi I, Fujii M, Osada H, Usami U, Hasegawa Y, Ito H, Hida T, Fujimoto N, Kishimoto T, Sekido S, Kondo Y
  • Journal Title: Carcinogenesis Volume: 33 Pages: 1277-1285
  • Peer Reviewed
• [Journal Article] Contribution of microRNA-1275 to Claudin 11 expression via polycomb-mediated silencing mechanism in human glioma stem-like cells (2012)
  • Author(s): Katsushima K, Shinjo K, Natsume A, Ohka F, Fujii F, Osada H, Sekido Y, Kondo Y
  • Journal Title: J Biol Chem Volume: 287 Pages: 27396-27406
  • Peer Reviewed
• [Journal Article] Conversion from the "oncogene addiction" to "drug addiction" by intensive inhibition of the EGFR and MET in lung cancer with activating EGFR mutation (2012)
  • Author(s): Suda K, Tomizawa K, Osada H, Maehara Y, Yatabe Y, Sekido Y, Mitsudomi T
  • Journal Title: Lung Cancer Volume: 76 Pages: 292-299
  • Peer Reviewed
• [Journal Article] The circadian clock gene BMAL1 is a novel therapeutic target for malignant mesothelioma (2012)
  • Author(s): Elshazley M, Sato M, Hase T, Takeyama Y, Yamashita R, Yoshida K, Toyokuni S, Ishiguro F, Osada H, Sekido Y, Yokoi K, Usami N, Shames DS, Kondo M, Gazdar AF, Minna JD, Hasegawa Y
  • Journal Title: Int J Cancer Volume: 131 Pages: 2820-2831
  • Peer Reviewed
• [Journal Article] Aberrant DNA methylation associated with aggressiveness of gastrointestinal stromal tumour (2012)
  • Author(s): Okamoto Y, Sawaki A, Ito S, Nishida T, Takahashi T, Toyota M, Suzuki H, Shinomura Y, Takeuchi I, Shinjo K, An B, Ito H, Yamao K, Fujii M, Murakami H, Osada H, Kataoka H, Joh T, Sekido Y, Kondo Y
  • Journal Title: GUT Volume: 61 Pages: 392-401
  • Peer Reviewed
• [Journal Article] NKX2-1/TITF1/TTF-1-induced ROR1 is required to sustain EGFR survival signaling in lung adenocarcinoma (2012)
  • Author(s): Yamaguchi T, et al
  • Journal Title: Cancer Cell Volume: 21 Issue: 3 Pages: 348-361
  • DOI: 10.1016/j.ccr.2012.02.008
  • Peer Reviewed
• [Journal Article] YAP induces malignant mesothelioma cell proliferation by upregulating transcription of cell cycle promoting genes. (2012)
  • Author(s): Mizuno T, Murakami H, Fujii M, Ishiguro F, Tanaka I, Kondo Y, Akatsuka S, Toyokuni S, Yokoi K, Osada H, Sekido Y
  • Journal Title: Oncogene Volume: 31 Issue: 49 Pages: 5117-22
  • DOI: 10.1038/onc.2012.5
  • Peer Reviewed
• [Journal Article] TGF-β synergizes with defects in the Hippo pathway to stimulate human malignant mesothelioma growth (2012)
  • Author(s): Fujii M, Toyoda T, Nakanishi H, Yatabe Y, Sato A, Matsudaira Y, Ito H, Murakami H, Kondo Y, Kondo E, Hida T, Tsujimura T, Osada H, Sekido Y.
  • Journal Title: J Exp Med Volume: VOL.209(3) Issue: 3 Pages: 479-494
  • DOI: 10.1084/jem.20111653
  • Peer Reviewed
• [Journal Article] Activated leukocyte cell adhesion molecule (ALCAM) promotes malignant phenotypes of malignant mesothelioma. (2012)
  • Author(s): Ishiguro F, Murakami H, Mizuno T, Fujii F, Kondo Y, Usami N, Yokoi K, Osada H, Sekido Y
  • Journal Title: J Thorac Oncol Volume: 7 Issue: 5 Pages: 890-9
  • DOI: 10.1097/jto.0b013e31824af2db
  • Peer Reviewed
• [Journal Article] Convergent signaling in the regulation of connective tissue growth factor in malignant mesothelioma: TGF-β signaling and defects in the Hippo signaling cascade. (2012)
  • Author(s): Fujii M, Nakanishi H, Toyoda T, Tanaka I, Kondo Y, Osada H, Sekido Y
  • Journal Title: Cell Cycle. Volume: 11 Issue: 18 Pages: 3373-9
  • DOI: 10.4161/cc.21397
• [Journal Article] Conversion from the "oncogene addiction" to "drug addiction" by intensive inhibition of the EGFR and MET in lung cancer with activating EGFR mutation. (2012)
  • Author(s): Suda K, et al.
  • Journal Title: Lung Cancer. Volume: 76 Issue: 3 Pages: 292-299
  • DOI: 10.1016/j.lungcan.2011.11.007
  • Peer Reviewed
• [Journal Article] The circadian clock gene BMAL1 is a novel therapeutic target for malignant mesothelioma. (2012)
  • Author(s): Elshazley M, Sato M, Hase T, Yamashita R, Yoshida K, Toyokuni S, Ishiguro F, Osada H, Sekido Y, Yokoi K, Usami N, Shames DS, Kondo M, Gazdar AF, Minna JD, Hasegawa Y
  • Journal Title: Int J Cancer Volume: 131 Issue: 12 Pages: 2820-31
  • DOI: 10.1002/ijc.27598
  • Peer Reviewed
• [Journal Article] Contribution of microRNA-1275 to Claudin11 suppression via a polycomb-mediated silencing mechanism in human glioma stem-like cells (2012)
  • Author(s): Katsushima K, Kondo Y, 8名
  • Journal Title: J Biol Chem. Volume: 287 Issue: 33 Pages: 27396-27406
  • DOI: 10.1074/jbc.m112.359109
  • Peer Reviewed
• [Journal Article] Integrated analysis of genetic and epigenetic alterations reveals CpG island methylator phenotype associated with distinct clinical characters of lung adenocarcinoma (2012)
  • Author(s): Shinjo K, Kondo Y, 14名
  • Journal Title: Carcinogenesis Volume: 33 Issue: 7 Pages: 1277-1285
  • DOI: 10.1093/carcin/bgs154
  • Peer Reviewed
• [Journal Article] Activated leukocyte cell adhesion molecule (ALCAM) promotes malignant phenotypes of malignant mesothelioma. (2012)
  • Author(s): Ishiguro F
  • Journal Title: J Thorac Oncol Volume: 7
  • Peer Reviewed
• [Journal Article] let-7 and miR-17-92 : Small-sized major players in lung cancer development (2011)
  • Author(s): Osada H and Takahashi T
  • Journal Title: Cancer Sci Volume: 102 Pages: 9-17
  • NAID: 10029287990
  • Peer Reviewed
• [Journal Article] miR-375 is activated by ASH1 and inhibits YAP1 in a lineage dependent manner in lung cancermiR-375 is activated by ASH1 and inhibits YAP1 in a lineage dependent manner in lung cancer (2011)
  • Author(s): Nishikawa E, Osada H, Okazaki Y, Arima C, Tomida S, Tatematsu Y, Taguchi A, Shimada Y, Yanagisawa K, Yatabe Y, Toyokuni S, Sekido Y, Takahashi T
  • Journal Title: Cancer Res Volume: 71 Pages: 6165-6173
  • Peer Reviewed
• [Journal Article] LATS2 is a tumor suppressor gene of malignant mesothelioma (2011)
  • Author(s): Murakami H, Mizuno T, Taniguchi T, Fujii M, Ishiguro F, Fukui T, Akatsuka S, Horio Y, Hida T, Kondo Y, Toyokuni S, Osada H, Sekido Y
  • Journal Title: Cancer Res Volume: 71 Pages: 873-883
  • Peer Reviewed
• [Journal Article] Epithelial to mesenchymal transition in an EGFR-mutant lung cancer cell line with acquired resistance to erlotinib (2011)
  • Author(s): Suda K, Tomizawa K, Fujii M, Murakami H, Osada H, Maehara Y, Yatabe Y, Sekido Y, Mitsudomi T
  • Journal Title: J Thorac Oncol Volume: 6 Pages: 1152-1161
  • Peer Reviewed
• [Journal Article] Distinct profiles of epigenetic evolution between colorectal cancers with and without metastasis (2011)
  • Author(s): Ju HX, An B, Okamoto Y, Shinjo K, Kanemitsu Y, Komori K, Hirai T, Shimizu Y, Sano T, Sawaki A, Tajika M, Yamao K, Fujii M, Murakami H, Osada H, Ito H, Takeuchi I, Sekido Y, Kondo Y
  • Journal Title: Am J Pathol Volume: 178 Pages: 1835-1846
  • Peer Reviewed
• [Journal Article] miR-375 is activated by ASH1 and inhibits YAP1 in a lineage-dependent manner. (2011)
  • Author(s): Nishikawa E
  • Journal Title: Cancer Research Volume: 71 Pages: 6165-6173
  • Peer Reviewed
• [Journal Article] let-7 and miR-17-92 : Small-sized major players in lung cancer development (2011)
  • Author(s): Osada H, Takahashi T
  • Journal Title: Cancer Science Volume: 102 Issue: 1 Pages: 9-17
  • DOI: 10.1111/j.1349-7006.2010.01707.x
  • NAID: 10029287990
  • Peer Reviewed
• [Journal Article] LATS2 is a tumor suppressor gene of malignant mesothelioma. (2011)
  • Author(s): Murakami H
  • Journal Title: Cancer Research Volume: 71 Pages: 873-883
  • Peer Reviewed
• [Journal Article] LIM-domain protein AJUBA suppresses malignant mesothelioma cell proliferation via Hippo signaling cascade
  • Author(s): Tanaka I, Osada H, Fujii M, Fukatsu A, Hida T, Horio Y, Kondo Y, Sato A, Hasegawa Y, Tsujimura T, Sekido Y
  • Journal Title: Oncogene Volume: (in press)
  • Peer Reviewed
• [Presentation] Functional analysis of CLCP1 as potential target for lung cancer diagnostics and therapeutics (2013)
  • Author(s): Osada H, Yagi K, Yanagisawa K, Akatsuka J, Tatematsu Y, Kato S, Yatabe Y, Ono K, Sekido Y, Takahashi T
  • Organizer: 72nd Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Yokohama (Oral Session)
• [Presentation] Analysis of CLCP1, a potential target for lung cancer diagnostics and therapeutics (2013)
  • Author(s): Osada H, Yagi K, Yanagisawa K, Akatsuka J, Tatematsu Y, Kato S, Yatabe Y, Ono K, Sekido Y, Takahashi T
  • Organizer: 36th Molecular Biology Society of Japan
  • Place of Presentation: Kobe (Poster Session)
• [Presentation] Functional analysis of CLCP1 as potential target for lung cancer diagnostics and therapeutics. (2013)
  • Author(s): Osada H. et al.
  • Organizer: 第72回 日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜(横浜市)
• [Presentation] Analysis of CLCP1, a potential target for lung cancer diagnostics and therapeutics. (2013)
  • Author(s): Osada H. et al.
  • Organizer: 第36回 日本分子生物学会年会
  • Place of Presentation: 神戸国際会議場(神戸市)
• [Presentation] Functional analysis of CLCP1 as a potential target for lung cancer diagnostics and therapeutics (2012)
  • Author(s): Osada H, Yagi K, Yanagisawa K, Akatsuka J, Tatematsu Y, Kato S, Yatabe Y, Ono K, Sekido Y, Takahashi T
  • Organizer: 71st Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Sapporo (Oral Session)
• [Presentation] Roles of ASH1-miR-375 pathway in development of lung cancers with neuroendocrine features (2011)
  • Author(s): Osada H, Nishikawa E, Arima C, Okazaki Y, Tomida S, Tatematsu Y, Taguchi A, Shimada Y, Yanagisawa K, Toyokuni S, Sekido Y, Takahashi, T
  • Organizer: 102nd Annual Meeting of the American Association for Cancer Research
  • Place of Presentation: Orlando, USA (Poster)
• [Presentation] Roles of ASH1- regulated miRNAs and lincRNAs in lung cancer development (2011)
  • Author(s): Osada H, Takahashi T
  • Organizer: 70th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Nagoya (Symposium)
• [Presentation] Roles of ASH1-miR-375 pathway in development of lung cancers with neuroendocrine features. (2011)
  • Author(s): Osada H
  • Organizer: 102nd AACR annual meeting
  • Place of Presentation: Orange County Convention Center (米国)
• [Presentation] YAP transcription coactivator induces malignant mesothelioma cell proliferation by up-regulating cell cycle progression (2011)
  • Author(s): Mizuno T
  • Organizer: the 14th World Conference on Lung Cancer
  • Place of Presentation: the Amsterdam RAI Exhibition and Convention Centre (オランダ)
• [Presentation] TGF-β synergizes with defects in the Hippo pathway to stimulate human malignant mesothelioma growth by inducing CTGF expression (2011)
  • Author(s): Fujii M
  • Organizer: FASEB SUMMER RESEARCH CONFERENCES
  • Place of Presentation: Il Ciocco (イタリア)
• [Presentation] Roles of ASH1-regulated miRNAs and lincRNAs in lung cancer development. (2011)
  • Author(s): Osada H
  • Organizer: 第70回日本癌学会学術総会(招待講演)
  • Place of Presentation: 名古屋国際会議場(名古屋)
• [Presentation] YAP transcriptional coactivator induces malignant mesothelioma cell proliferation via up-regulating cell cycle-regulating genes including CCND1 (2011)
  • Author(s): Mizuno T
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場(名古屋)
• [Presentation] Overexpression of activated leukocyte cell adhesion molecule is involved in invasion of malignant mesothelioma cells (2011)
  • Author(s): Ishiguro F
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場(名古屋)
• [Presentation] 悪性中皮腫細胞の増殖におけるTGF-βシグナルとhippo pathwayの役割 (2011)
  • Author(s): 藤井万紀子
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場(名古屋)
• [Presentation] A LIM protein ajuba suppresses malignant mesothelioma cell proliferation via Hippo signaling cascade
  • Author(s): Tanaka I, et al.
  • Organizer: AACR annual meeting 2013
  • Place of Presentation: The Walter E. Washington Convention Center (米国)
• [Presentation] NKX2-1/TITF1/TTF-1-induced ROR1 is required to sustain EGFR survival signaling in lung adenocarcinoma.
  • Author(s): Yamaguchi T, et al.
  • Organizer: AACR annual meeting 2012
  • Place of Presentation: McCormick Place West (米国)
• [Presentation] TGF-β synergistically stimulates malignant mesothelioma growth with defects in the Hippo pathway by inducing CTGF expression
  • Author(s): Fujii M, et al.
  • Organizer: AACR annual meeting 2012
  • Place of Presentation: McCormick Place West (米国)
• [Presentation] Epigenetic regulation of miR-1275 through histone H3 lysine 27 trimethylation during human glioma stem-like cell differentiation
  • Author(s): Katsushima K, et al.
  • Organizer: AACR annual meeting 2012
  • Place of Presentation: McCormick Place West (米国)
• [Presentation] Integrated analysis of genetic and epigenetic alterations reveals CpG island methylator phenotype associated with distinct clinical characters of lung adenocarcinoma.
  • Author(s): ShinjoK, et al.
  • Organizer: AACR annual meeting 2012
  • Place of Presentation: McCormick Place West (米国)
• [Presentation] Functional analysis of CLCP1 as a potential target for lung cancer diagnostics and therapeutics.
  • Author(s): Osada H, et al.
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌市教育文化会館（札幌）
• [Book] microRNA 発現異常と発癌 実験医学増刊 29 (2) (2011)
  • Author(s): 長田 啓隆、高橋 隆
• [Remarks]
  • URL: http://www.pref.aichi.jp/cancer-center/ri/01bumon/03bunshi_shuyo/index.html
• [Remarks] 愛知県がんセンター研究所 分子腫瘍学部
  • URL: http://www.pref.aichi.jp/cancer-center/ri/01bumon/03bunshi_shuyo/index.html
• [Remarks] 愛知県がんセンター研究所 分子腫瘍学部
  • URL: http://www.pref.aichi.jp/cancer-center/ri/01bumon/03bunshi_shuyo/index.html
• [Remarks]
  • URL: http://www.pref.aichi.jp/cancer-center/ri/01bumon/03bunshi_shuyo/index.html