| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
Cancer cells are refractory in the hypoxic region of solid tumors. The mechanism of refractory hypoxic cancer cells should be clarified. We previously reported that deprivation of oxygen and glucose reduced c-Myc protein to make cancer cells dormant and inhibit cell death. In this study, we cultured primary colorectal cancer cells three dimensionally and found that hypoxic treatment reduced c-Myc protein in primary cancer cells. In addition, we found that ER stress might contribute to reduction of c-Myc protein in primary cancer cells.
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