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Hypoxia-induced dormancy identified by a novel 3D culture method of primary cancer

Research Project

Project/Area Number 23501282
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Tumor biology
Research InstitutionResearch Institute, Osaka Medical Center for Cancer and Cardiovascular Disaeses

Principal Investigator

OKUYAMA Hiroaki  地方独立行政法人大阪府立病院機構大阪府立成人病センター(研究所), 研究所, 総括研究員 (50432373)

Co-Investigator(Kenkyū-buntansha) INOUE Masahiro  地方独立行政法人大阪府立病院機構大阪府立成人病センター(研究所), 研究所, 部長 (10342990)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsがん細胞の特性 / 低酸素 / dormancy / 初代培養 / 大腸がん / MYC / HIF
Research Abstract

Cancer cells are refractory in the hypoxic region of solid tumors. The mechanism of refractory hypoxic cancer cells should be clarified. We previously reported that deprivation of oxygen and glucose reduced c-Myc protein to make cancer cells dormant and inhibit cell death. In this study, we cultured primary colorectal cancer cells three dimensionally and found that hypoxic treatment reduced c-Myc protein in primary cancer cells. In addition, we found that ER stress might contribute to reduction of c-Myc protein in primary cancer cells.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (2 results)

All 2013

All Journal Article (2 results) (of which Peer Reviewed: 2 results)

  • [Journal Article] Involvement of Heregulin/HER3 in the Primary Culture of Human Urothelial Cancer2013

    • Author(s)
      Hiroaki Okuyama, Takahiro Yoshida, Hiroko Endo, Masashi Nakayama, Norio Nonomura, Kazuo Nishimura and Masahiro Inoue
    • Journal Title

      Journal of Urology

      Volume: Vol 190 Pages: 302-310

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of Heregulin/HER3 in the Primary Culture of Human Urothelial Cancer2013

    • Author(s)
      Hiroaki Okuyama
    • Journal Title

      Journal of Urology

      Volume: Epub ahead of print Issue: 1 Pages: 302-310

    • DOI

      10.1016/j.juro.2012.12.106

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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