Hypoxia-induced dormancy identified by a novel 3D culture method of primary cancer
| Project/Area Number |
23501282
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor biology
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| Research Institution | Research Institute, Osaka Medical Center for Cancer and Cardiovascular Disaeses |
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Principal Investigator |
OKUYAMA Hiroaki 地方独立行政法人大阪府立病院機構大阪府立成人病センター(研究所), 研究所, 総括研究員 (50432373)
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| Co-Investigator(Kenkyū-buntansha) |
INOUE Masahiro 地方独立行政法人大阪府立病院機構大阪府立成人病センター(研究所), 研究所, 部長 (10342990)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | がん細胞の特性 / 低酸素 / dormancy / 初代培養 / 大腸がん / MYC / HIF |
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| Research Abstract |
Cancer cells are refractory in the hypoxic region of solid tumors. The mechanism of refractory hypoxic cancer cells should be clarified. We previously reported that deprivation of oxygen and glucose reduced c-Myc protein to make cancer cells dormant and inhibit cell death. In this study, we cultured primary colorectal cancer cells three dimensionally and found that hypoxic treatment reduced c-Myc protein in primary cancer cells. In addition, we found that ER stress might contribute to reduction of c-Myc protein in primary cancer cells.
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Report
(4 results)
Research Products
(2 results)
