The development of new immunotherapy by regulating immune checkpoint molecules for the treatment of digestive cancers
| Project/Area Number |
23501285
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor immunology
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| Research Institution | Tottori University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 免疫治療 / 消化器癌 / T細胞 / Tim-3 / LAG-3 / 胃癌 / PD-1 / Tリンパ球 / 免疫逃避機構 |
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| Research Abstract |
There are lots of patients who die due to cancer in Japan. The standard treatments for cancer are surgery, chemotherapy, and radiation therapy. Although recent progress in those therapies improve prognosis of cancer patients, many patients still die due to cancer. Therefore, the development of new effective therapy is indispensable to improve prognosis of cancer patients. Immunotherapy is considered to be a most promising candidate. We performed current study to develop new effective immunotherapy for the treatment of digestive cancer. In the current study, we found that the function of T cells was impaired and this phenomenon was induced by up-regulation of various immune checkpoint molecules. Furthermore, we have demonstrated that T cell function could be recovered by regulating these molecules. This approach may be the breakthrough for the treatment of cancer patients.
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Report
(4 results)
Research Products
(9 results)
