| Project/Area Number |
23501318
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Clinical oncology
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| Research Institution | Fukuoka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAMURA Kazuo 福岡大学, 医学部, 教授 (60145422)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 高齢者 / がん薬物療法 / 包括的機能評価 / 日常生活の質 / 外来化学療法 / 機能評価 / 薬物動態 |
|---|
| Outline of Final Research Achievements |
Older patients of same chronologic ages differ widely in physical and psychological function. Treatment strategy should be altered according to functional assessments of each patient. We underwent the comprehensive geriatric assessment (CGA), including psychological status, activities of daily living (ADL), instrumental ADL (IADL), nutritional status, comorbidity and cognitive function in patients with newly diagnosed malignant lymphoma. High ages, advanced stages and severe comorbidities were significantly associated with high incidence of treatment discontinuation, while high ages, ADL-dependencies and accumulation of severe comorbidities were significantly associated with low complete remission (CR) rates. ADL-dependency was significantly associated with overall survival. Performance status was not associated with either CR rate or OS. It indicates that CGA is an effective tool for predicting clinical outcomes in elderly patients who received anti-cancer chemotherapy.
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