Study on the exact mechanism for the polychlorinated biphenyl-induced decrease in the serum thyroxine level
| Project/Area Number |
23510083
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Tokushima Bunri University |
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Principal Investigator |
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | PCB / 甲状腺ホルモン撹乱 / サイロキシン / UDP-グルクロン酸転移酵素 / トランスサイレチン / 肝臓 / グルクロン酸抱合酵素 / ラット / マウス / 3,3',4,4'-テトラクロロビフェニル / 2,3',4,4',5-ペンクロロビフェニル / 2,2',4,5,5'-ペンクロロビフェニル / TTRノックアウトマウス |
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| Outline of Final Research Achievements |
We have demonstrated that polychlorinated biphenyl(PCB)-mediated decrease in serum thyroxine (T4) level in rats and mice occurred mainly through increased accumulation of T4 in the liver and partially through increased excretion of biliary T4 metabolite(s), development of liver hypertrophy and/or the inhibition of a T4-transthyretin complex formation. Since the several transporters, including apical and basolateral T4-transporters, are reported to exist in the liver cells, further studies on PCB-mediated changes in the expression and activity of hepatic T4 transporter(s) are necessary to understand the liver-selective accumulation of T4.
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Report
(5 results)
Research Products
(53 results)
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[Journal Article] Distribution and excretion of 2,2',3,4',5,5',6-heptachlorobiphenyl (CB187) and its metabolites in rats and guinea pigs2015
Author(s)
Chiho Ohta, Koichi Haraguchi, Yoshihisa Kato, Tetsuya Endo, Osamu Kimura, Nobuyuki Koga
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Journal Title
Chemosphere
Volume: 118
Pages: 5-11
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] 3,3′,4,4′-Tetrachlorobiphenyl-Mediated Decrease of Serum Thyroxine Level in C57BL/6 and DBA/2 Mice Occurs Mainly through Enhanced Accumulation of Thyroxine in the Liver2014
Author(s)
Yoshihisa Kato, Koichi Haraguchi, Mao Onishi, Shinichi Ikushiro, Tetsuya Endo, Chiho Ohta, Nobuyuki Koga, Shizuo Yamada, and Masakuni Degawa
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Journal Title
Biological and Pharmaceutical Bulletin
Volume: 37
Issue: 3
Pages: 504-509
DOI
NAID
ISSN
0918-6158, 1347-5215
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] A Possible Mechanism for 2,3′,4,4′,5′-Pentachlorobiphenyl-Mediated Decrease in Serum Thyroxine Level in Mice2013
Author(s)
Yoshihisa Kato, Mao Onishi, Koichi Haraguchi, Shinichi Ikushiro, Chiho Ohta, Nobuyuki Koga, Tetsuya Endo, Shizuo Yamada, and Masakuni Degawa
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Journal Title
Biological and Pharmaceutical Bulletin
Volume: 36
Issue: 10
Pages: 1594-1601
DOI
NAID
ISSN
0918-6158, 1347-5215
Related Report
Peer Reviewed
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[Presentation] In vitro metabolism of 3,5,6,7,8,3’,4’-heptamethoxyflavone by rat liver microsomes2013
Author(s)
Nobuyuki Koga, Mikiko Matsuoka, Chiho Ohta, Yoshihisa Kato, Koichi Haraguchi, Osamu Kimura and Tetsuya Endo
Organizer
20th International Congress of Nutrition
Place of Presentation
Granada, Spein
Related Report
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