Antimicrobial peptide model conctructed on a nono molecuar space

Research Project

Project/Area Number	23550191
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Chemistry related to living body
Research Institution	Nagoya Institute of Technology
Principal Investigator	YAMAMURA Hatsuo 名古屋工業大学, 工学(系)研究科(研究院), 教授 (80220440)
Project Period (FY)	2011 – 2013
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000) Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords	シクロデキストリン / ペプチド / 抗菌
Research Abstract	An antimicrobial peptide model was studied by use of cyclodextrin. Amino groups and alkyl groups those interact with lipid molecules of a microbial membrane to disrupt the membrane was introduced onto the cyclodextrin molecule. Antimicrobial activities of the derivatives were examined and discussed.