Research Project
Grant-in-Aid for Scientific Research (C)
The estrogen receptor interacts with estrogen which is female sex hormone, and participates in mechanism of the homeostatic maintenance of the vertebrates. However, it is yet unknown that the molecular evolution of estrogen receptor gene and protein. This research theme was carried out for the appearance of the estrogen receptor gene with the organic evolution and the elucidation of the process of the gain of function. As a result, it became clear that the elasmobranchii has the estrogen receptor genes that encode a functional receptor like higher vertebrates. Our functional analysis suggest that the function of estrogen receptor as a hormone-dependent transcription factor might be gain through the evolutionary process. The above-mentioned result will become the important clue in elucidating the molecular evolution of the estrogen receptor.
All 2013 2012 2011 Other
All Journal Article (15 results) (of which Peer Reviewed: 15 results) Presentation (17 results) (of which Invited: 4 results) Remarks (2 results)
J. Appl. Toxicol
Volume: 33 Issue: 9 Pages: 991-1000
10.1002/jat.2825
Mol. Cell. Endocrinol.
Volume: 365 Issue: 2 Pages: 153-161
10.1016/j.mce.2012.10.014
120005228364
Aquat. Toxicol.
Volume: 142-143 Pages: 403-413
10.1016/j.aquatox.2013.09.008
Aquatic Toxicology
Volume: 109 Pages: 250-258
10.1016/j.aquatox.2011.09.004
Chemosphere
Volume: 87 Issue: 7 Pages: 668-674
10.1016/j.chemosphere.2011.12.047
Toxicology
Volume: 296 Issue: 1-3 Pages: 13-19
10.1016/j.tox.2012.02.010
In vivo
Volume: 26 Pages: 899-906
J Vet Med Sci
Volume: 74 Pages: 1589-1595
130001879705
J.Appl.Toxicol.
Volume: 33 Issue: 1 Pages: 41-49
10.1002/jat.1707
J. Steroid Biochem. Mol. Biol.
Volume: 123 Issue: 3-5 Pages: 115-121
10.1016/j.jsbmb.2010.11.015
Mol. Cell. Endocrinol
Volume: 333 Issue: 1 Pages: 47-54
10.1016/j.mce.2010.12.002
Mol. Cel. Endcrinol.
Volume: 333 Issue: 2 Pages: 190-199
10.1016/j.mce.2010.12.025
Volume: 127 Issue: 1-2 Pages: 58-63
10.1016/j.jsbmb.2011.01.004
Volume: 103 Issue: 1-2 Pages: 101-111
10.1016/j.aquatox.2011.02.012
Environ. Sci. Technol.
Volume: 45 Issue: 8 Pages: 3759-3767
10.1021/es103814d
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