Studies on structure and function of sex steroids in amphioxus
Project/Area Number |
23570070
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Morphology/Structure
|
Research Institution | The University of Tokyo |
Principal Investigator |
KUBOKAWA Kaoru 東京大学, 理学(系)研究科(研究院), 特任教授 (30240740)
|
Co-Investigator(Renkei-kenkyūsha) |
ANDO Hironori 新潟大学, 佐渡臨海実験所, 教授 (60221743)
|
Research Collaborator |
KATSU Yoshinao
KATO Akiko
KOJIMA Ayaka
ROY Sonali
URANO Akihisa
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Project Period (FY) |
2011-04-28 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
Keywords | 性ステロイド / ナメクジウオ / 脊索動物 / 進化 / 神経索 / in situ ハイブリダイゼーション / エストロゲン / 卵巣 / 精巣 / 糖タンパク質ホルモン / 神経内分泌 / ステロイド / ステロイド受容体 / ホルモン |
Outline of Final Research Achievements |
Sex steroids are specific hormones in vertebrates, which control the reproductive function and maintain the balance of the nerve and visceral activities of the body. Their role is manifested through a complex metabolic system of steroidogenesis Thus, new functions of the sex steroid system are being discovered; however, many other functions remain unknown. In this study, we examined the sex steroid metabolic system of amphioxus. We found a major sex steroid metabolic pathway, 5α-reduced steroid, which is rarely used in vertebrates. In addition, the sex steroids are actively synthesized in the nerve system. It suggests that sex steroidogenesis of vertebrates is acquired in step with the evolution of a notochord and diverged during the evolution in Chordata.
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Report
(5 results)
Research Products
(20 results)
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[Journal Article] Shallow submarine hydrothermal activity with significant contribution of magmatic water producing talc chimneys in the Wakamiko Crater of Kagoshima Bay, southern Kyushu, Japan.2013
Author(s)
Yamanaka, T., Maeto, K., Akashi, H., Ishibashi, J., Miyoshi, Y., Okamura, K., Noguchi, T., Kuwahara, Y., Toki, T., Tsunogai, U., Ura, T., Nakatani, T., Maki, T., Kubokawa, K., and Chiba, H.
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Journal Title
J. Volcan. Geotherm. Res.
Volume: (in press)
Pages: 74-84
DOI
Related Report
Peer Reviewed
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[Journal Article] Actin capping proteins, CapZ (β-actinin) and tropomodulin in amphioxus striated muscle2012
Author(s)
Bao, Y., Kake, T., Hanashima, A., Nomiya, U., Kubokawa, K. and Kimura, S.
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Journal Title
Gene
Volume: Vol. 510 (1)
Issue: 1
Pages: 78-86
DOI
Related Report
Peer Reviewed
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[Journal Article] Amphioxus connectin exhibits merged structure as invertebrate connectin in I-band region and vertebrate connectin in A-band region2011
Author(s)
Ohtsuka, S., Hanashima, A., Kubokawa, K., Bao, Y., Tando, Y., Kohmaru, J., Nakaya, H., Maruyama, K. and Kimura, S.
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Journal Title
J. Mol. Biol
Volume: Vol. 409 (3)
Issue: 3
Pages: 415-426
DOI
Related Report
Peer Reviewed
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