GABAergic modulation on the oscillatory activity and network reconstruction in the slug olfactory center
| Project/Area Number |
23570099
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Animal physiology/Animal behavior
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| Research Institution | Tokushima Bunri University |
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Principal Investigator |
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | GABA / oscillatory network / laminar structure / olfactory center / slug / cultured neuron / electrophysiology / plasticity / network reorganization |
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| Outline of Final Research Achievements |
Synchronous oscillatory activity is common in the olfactory behavior of both vertebrates and invertebrates. In the terrestrial slugs, periodic oscillation is recorded from the surface of the laminar structure of olfactory center, procerebrum (PC) and its frequency changes are suggested to encode the olfactory information and memory. Gamma-aminobutyric acid (GABA) neurons are known to inhibitory neurons as a kernel of rhythm generation in oscillatory networks of vertebrate. In the present study, we found that GABAergic neuron has a role to play as an excitatory modulator in the PC oscillatory network of the slugs. This observation and the conclusion have been supported by the pharmacological study in reconstructed oscillatory networks of cultured PC neurons.
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Report
(5 results)
Research Products
(19 results)
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[Journal Article] Involvement of insulin-like peptide in long-term synaptic plasticity and long-term memory of the pond snail Lymnaea stagnalis.2013
Author(s)
Murakami J, Okada R, Sadamoto H, Kobayashi S, Mita K, Sakamoto Y, Yamagishi M, Hatakeyama D, Otsuka E, Okuta A, Sunada H, Takigami S, Sakakibara M, Fujito Y, Awaji M, Moriyama S, Lukowiak K, Ito E.
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Journal Title
J Neurosci
Volume: 33
Pages: 371-383
Related Report
Peer Reviewed
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