Isolation and characterization of ubiquitin-like protein MNSF-conjugating enzymes
Project/Area Number |
23570138
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Structural biochemistry
|
Research Institution | Shimane University |
Principal Investigator |
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | ユビキチン様タンパク質 / 結合酵素 / 翻訳後修飾 / ユビキチン類似タンパク質 / タンパク質翻訳後修飾 |
Research Abstract |
In this study, we identified and characterized an enzyme which conjugates MNSF to target protein(s). This enzyme is a novel protein similar to ubiquitin conjugating enzyme E3. In addition, we also identified a heat shock protein which stabilizes aggregative MNSF. Thus, the mechanism of MNSF conjugation was partly shown.
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Report
(4 results)
Research Products
(30 results)