• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Formation and function of SHAP-hyaluronan complex as a niche molecule in inflammatory microenvironment

Research Project

Project/Area Number 23570148
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Structural biochemistry
Research InstitutionAichi Medical University

Principal Investigator

KIMATA Koji  愛知医科大学, その他部局等, 名誉教授 (10022641)

Co-Investigator(Kenkyū-buntansha) ZHUO Lisheng  愛知医科大学, 公私立大学の部局等, その他 (00399031)
Project Period (FY) 2011-04-28 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords炎症 / 酵素 / 細胞接着 / ヒアルロン酸 / 血清タンパク質 / 血清蛋白質
Outline of Final Research Achievements

Serum-derived hyaluronan (HA)-associated proteins (SHAP) binds covalently to HA, which plays important roles in inflammation and tumor malignance, to assign it novel physiological functions. This project aims to isolate the enzymatic factor calalyzing the formation of the SHAP-HA complex and screen its inhibitor. In addition, the roles of the SHAP-HA complex as a member of inflammatory niche in mouse models of acute liver failure, functional regeneration of muscle after injury by mesenchymal stem cell transplantation, and chronic painful scar are investigated.

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (55 results)

All 2015 2014 2013 2012 2011

All Journal Article (43 results) (of which Peer Reviewed: 42 results,  Open Access: 5 results,  Acknowledgement Compliant: 6 results) Presentation (8 results) (of which Invited: 3 results) Book (4 results)

  • [Journal Article] Inhibition of hyaluronan synthesis alters sulfated glycosaminoglycans deposition during chondrogenic differentiation in ATDC5 cells.2015

    • Author(s)
      Yoshioka Y, Kozawa E, Urakawa H, Arai E, Futamura N, Zhuo L, Kimata K, Ishiguro N, Nishida Y.
    • Journal Title

      Histochem Cell Biol.

      Volume: not determined

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] マウス術後痛モデル動物が示す行動学的変化と術後瘢痕部およびDRGの病態2015

    • Author(s)
      李玉強、木全弘治、飯田博己、卓麗聖、牛田享宏
    • Journal Title

      愛知医大誌

      Volume: 未定

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Human blood glycosaminoglycans: isolation and analysis2015

    • Author(s)
      Anower-E-Khuda MF, Kimata K.
    • Journal Title

      Methods Mol Biol.

      Volume: 1229 Pages: 95-103

    • DOI

      10.1007/978-1-4939-1714-3_10

    • ISBN
      9781493917136, 9781493917143
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Glomerular basement membrane (GBM) abnormalities are worth pursuing.2014

    • Author(s)
      Takagi J, Morita H, Kimata K.
    • Journal Title

      Clin Exp Nephrol.

      Volume: Sep 6 Issue: 3 Pages: 329-330

    • DOI

      10.1007/s10157-014-1025-7

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sulfated Glycosaminoglycans Control the Extracellular Trafficking and the Activity of the Metalloprotease Inhibitor TIMP-3.2014

    • Author(s)
      Troeberg L, Lazenbatt C, Anower-E-Khuda MF, Freeman C, Federov O, Habuchi H, Habuchi O, Kimata K, Nagase H.
    • Journal Title

      Chem Biol.

      Volume: 21 Issue: 10 Pages: 1300-1309

    • DOI

      10.1016/j.chembiol.2014.07.014

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Ancient origin of mast cells2014

    • Author(s)
      Wong GW, Zhuo L, Kimata K, Lam BK, Satoh N, Stevens RL
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 451 Issue: 2 Pages: 314-318

    • DOI

      10.1016/j.bbrc.2014.07.124

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Hyaluronan expression as a significant prognostic factor in patients with ma lignant peripheral nerve sheath tumors.2014

    • Author(s)
      Ikuta K, Urakawa H, Kozawa E, Arai E, Zhuo L, Futamura N, Hamada S, Kimata K, Ishiguro N, Nishida Y.
    • Journal Title

      Clin Exp Metastasis

      Volume: 31 Issue: 6 Pages: 715-725

    • DOI

      10.1007/s10585-014-9662-5

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Hyaluronan Deficiency Due to Has3 Knock-Out Causes Altered Neuronal Activity and Seizures via Reduction in Brain Extracellular Space.2014

    • Author(s)
      Arranz AM, Perkins KL, Irie F, Lewis DP, Hrabe J, Xiao F, Itano N, Kimata K, Hrabetova S, Yamaguchi Y.
    • Journal Title

      J Neurosci.

      Volume: 34 Issue: 18 Pages: 6164-6176

    • DOI

      10.1523/jneurosci.3458-13.2014

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Activation of endothelial TLR4 and Kupffer cells coordinate neutrophil adhesion within liver sinusoids during endotoxemia.2013

    • Author(s)
      McDonald B, Jenne CN, Zhuo L, Kimata K, Kubes P.
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol.

      Volume: 305 Issue: 11 Pages: G797-G806

    • DOI

      10.1152/ajpgi.00058.2013

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Homotypic Versican G1 Domain Interactions Enhance Hyaluronan Incorporation into Fibrillin Microfibrils.2013

    • Author(s)
      Murasawa Y, Watanabe K, Yoneda M, Zako M, Kimata K, Sakai LY, Isogai Z.
    • Journal Title

      J Biol Chem.

      Volume: 288 Issue: 40 Pages: 29170-29181

    • DOI

      10.1074/jbc.m113.456947

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Crucial role of hyaluronan in neointimal formation after vascular injury.2013

    • Author(s)
      Kashima Y, Takahashi M, Shiba Y, Itano N, Izawa A, Koyama J, Nakayama J, Taniguchi S, Kimata K, Ikeda U.
    • Journal Title

      PLoS One

      Volume: 8 Issue: 3 Pages: e58760-e58760

    • DOI

      10.1371/journal.pone.0058760

    • Related Report
      2013 Research-status Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Glycosaminoglycans in blood of hereditary multiple exostoses patients: Half reduction of heparan sulfate to chondroitin sulfate ratio and the possible diagnostic application.2013

    • Author(s)
      Anower-E-Khuda MF, Matsumoto K, Habuchi H, Morita H, Yokochi T, Shimizu K, Kimata K.
    • Journal Title

      Glycobiology

      Volume: 23 Issue: 7 Pages: 865-876

    • DOI

      10.1093/glycob/cwt024

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Suppression of hyaluronan synthesis alleviates inflammatory response in murine arthritis and in human rheumatoid synovial fibroblasts.2013

    • Author(s)
      Yoshioka Y, Kozawa E, Urakawa H, Arai E, Futamura N, Zhuo L, Kimata K, Ishiguro N, Nishida Y.
    • Journal Title

      Arthritis Rheum.

      Volume: 65 Issue: 5 Pages: 1160-1170

    • DOI

      10.1002/art.37861

    • Related Report
      2013 Research-status Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Heparan sulfate 6-O-sulfotransferase isoform-d ependent regulatory effects of heparin on the activities of various proteases in mast cells a nd the biosynthesis of 6-O-sulfated heparin.2013

    • Author(s)
      Anower-E-Khuda MF, Habuchi H, Nagai N, Habuchi O, Yokochi T, Kimata K.
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 288 Issue: 6 Pages: 3705-3717

    • DOI

      10.1074/jbc.m112.416651

    • Related Report
      2013 Research-status Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Role of hyaluronan synthase 1 in the changes of hyaluronan content and size distribution after intracerebral hemorrhage in mice2013

    • Author(s)
      Ding H, Jiang J, Y Tang, Dong Y, Dong Q, Ren H, Zhuo L, Kimata K
    • Journal Title

      Chin J Clin Neurosci

      Volume: 21 Pages: 138-145

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Involvement of heparan sulfate 6-O-sulfation in regulation of energy metabolism and alteration of thyroid hormone levels in male mice.2013

    • Author(s)
      Nagai N, Habuchi H, Sugaya N, Nakamura M, Imamura T, Watanabe H, Kimata K.
    • Journal Title

      Glycobiology

      Volume: 23 Issue: 8 Pages: 980-992

    • DOI

      10.1093/glycob/cwt037

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Nephronectin binds to heparan sulfate proteoglycans via its MAM domain2013

    • Author(s)
      佐藤 祐哉
    • Journal Title

      Matrix Biology

      Volume: VOL. 32 Issue: 3-4 Pages: 188-195

    • DOI

      10.1016/j.matbio.2013.01.005

    • Related Report
      2013 Research-status Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Moderate repulsive effects of E-unit-containing chondroitin sulfate (CSE) on behavior of retinal growth cones.2013

    • Author(s)
      Shimbo M, Ando S, Sugiura N, Kimata K, Ichijo H. Brain Res. 2013 Jan 23;1491:34-43.
    • Journal Title

      Brain Res.

      Volume: 1491 Pages: 34-43

    • DOI

      10.1016/j.brainres.2012.11.011

    • NAID

      120005257182

    • Related Report
      2013 Research-status Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Inhibitory effect of chondroitin sulfate type e on the binding step of human T-cell leukemia virus type 1.2013

    • Author(s)
      Jinno-Oue A, Tanaka A, Shimizu N, Mori T, Sugiura N, Kimata K, Isomura H, Hoshino H.
    • Journal Title

      AIDS Res Hum Retroviruses.

      Volume: 29 Issue: 3 Pages: 621-629

    • DOI

      10.1089/aid.2012.0156

    • Related Report
      2013 Research-status Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Sulfation of the bikunin chondroitin sulfate chain determines heavy chain·hyaluronan complex formation2013

    • Author(s)
      Lord MS, Day AJ, Youssef P, Zhuo L, Watanabe H, Caterson B, Whitelock JM.
    • Journal Title

      J Biol Chem.

      Volume: 288 Issue: 32 Pages: 22930-22941

    • DOI

      10.1074/jbc.m112.404186

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Application of chondroitin sulfate derivatives for understanding axonal guidance in the nervous system during development2013

    • Author(s)
      Ichijo H, Sugiura N, Kimata K
    • Journal Title

      Polymers

      Volume: 5 Pages: 254-268

    • NAID

      120005257181

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Role of hyaluronan synthase 1 in the changes of hyaluronan content and size distribution after intracerebral hemorrhage in mice.2013

    • Author(s)
      Ding H, Jiang J, Y Tang, Dong Y, Dong Q, Ren H, Zhuo L, Kimata K.
    • Journal Title

      Chin J Clin Neurosci

      Volume: 21 Pages: 138-145

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 血清蛋白その他の生化学検査:ヒアルロン酸2013

    • Author(s)
      卓麗聖、木全弘治
    • Journal Title

      内科

      Volume: 111

    • Related Report
      2012 Research-status Report
  • [Journal Article] Single-Molecular Enzymatic Elongation of Hyaluronan Polymers Visualized by High-Speed Atomic Force Microscopy2012

    • Author(s)
      Toshiaki Mori, Atsushi Hirose, Tatsuya Hagiwara, Masanori Ohtsuka, Yoshimitsu Kakuta, Koji Kimata, and Yoshio Okahata
    • Journal Title

      J. Am. Chem. Soc.

      Volume: 134 Issue: 50 Pages: 20254-20257

    • DOI

      10.1021/ja309646s

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Construction of a chondroitin sulfate library with defined structures and analysis of molecular interactions.2012

    • Author(s)
      Sugiura N, Shioiri T, Chiba M, Sato T, Narimatsu H, Kimata K, Watanabe H
    • Journal Title

      J Biol Chem

      Volume: 287 Issue: 52 Pages: 43390-43400

    • DOI

      10.1074/jbc.m112.412676

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Chondroitin sulfate synthase-2 is necessary for chain extension of chondroitin sulfate but not critical for skeletal development.2012

    • Author(s)
      Ogawa H, Hatano S, Sugiura N, Nagai N, Sato T, Shimizu K, Narimatsu H, Kimata K, Watanabe H
    • Journal Title

      PLoS ONE

      Volume: 7 Issue: 8 Pages: 1-12

    • DOI

      10.1371/journal.pone.0043806

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] The structural basis for a coordinated reaction catalyzed by a bifunctional glycosyltransferase in chondroitin biosynthesis.2012

    • Author(s)
      Sobhany M, Kakuta Y, Sugiura N, Kimata K, Negishi M.
    • Journal Title

      J Biol Chem.

      Volume: 287 Issue: 43 Pages: 36022-36028

    • DOI

      10.1074/jbc.m112.375873

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Versican/PG-M is essential for ventricular septal formation subsequent to cardiac atrioventricular cushion development2012

    • Author(s)
      S. Hatano, K. Kimata, N. Hiraiwa, M. Kusakabe, Z. Isogai, E. Adachi, T. Shinomura, and H. Watanabe
    • Journal Title

      Glycobiology

      Volume: 22 (9) Issue: 9 Pages: 1268-1277

    • DOI

      10.1093/glycob/cws095

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of dexamethasone on tissue injury and reconstruction in ethanol/steroid injection therapy for allergic rhinitis2012

    • Author(s)
      Kimura M, Sugaya N, Kimata K, Kawachi M, Sawada M, Kuroda H, Takei M, Inafuku S and Wu M-D
    • Journal Title

      J Aller Ther

      Volume: S5 Pages: 2155-6121

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hyaluronan expressed by the hematopoietic microenvironment is required for bone marrow hematopoiesis.2012

    • Author(s)
      Goncharova V, Serobyan N, Iizuka S, Schraufstatter I, de Ridder A, Povaliy T, Wacker V, Itano N, Kimata K, Orlovskaja IA, Yamaguchi Y, Khaldoyanidi S.
    • Journal Title

      J Biol Chem.

      Volume: 287 Issue: 30 Pages: 25419-25433

    • DOI

      10.1074/jbc.m112.376699

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Kinetics of iterative carbohydrate transfer to polysaccharide catalyzed by chondroitin polymerase on a highly sensitive flow-type 27 MHz quartz-crystal microbalance.2012

    • Author(s)
      Mori T, Kodera T, Yoshimine H, Kakuta Y, Sugiura N, Kimata K, Okahata Y.
    • Journal Title

      Chemistry

      Volume: 18 Issue: 24 Pages: 7388-7393

    • DOI

      10.1002/chem.201200342

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Heparan sulfate subdomains that are degraded by Sulf accumulate in cerebral amyloid beta plaques of Alzheimer's disease : Evidence from mouse models and patients2012

    • Author(s)
      Hosono-Fukao, T, et al
    • Journal Title

      Am.J.Pathol

      Volume: 180 Issue: 5 Pages: 2056-2067

    • DOI

      10.1016/j.ajpath.2012.01.015

    • Related Report
      2012 Research-status Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Restriction of mast cell proliferation through hyaluronan synthesis by co-cultured fibroblasts.2012

    • Author(s)
      Takano H, Furuta K, Yamashita K, Sakanaka M, Itano N, Gohda E, Nakayama K, Kimata K, Sugimoto Y, Ichikawa A, Tanaka S.
    • Journal Title

      Biol Pharm Bull.

      Volume: 35 Pages: 408-412

    • NAID

      130001872324

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Crystallization and X-ray diffraction analysis of chondroitin lyase from baculovirus: envelope protein ODV-E66.2012

    • Author(s)
      Kawaguchi Y, Sugiura N, Onishi M, Kimata K, Kimura M, Kakuta Y.
    • Journal Title

      Acta Crystallogr Sect F Struct Biol Cryst Commun.

      Volume: 68 Issue: 2 Pages: 190-192

    • DOI

      10.1107/s1744309111053164

    • Related Report
      2012 Research-status Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Enhanced inflammation and accelerated wound closure following tetraphorbol ester application or full-thickness wounding in mice lacking hyaluronan synthases Has1 and Has3.2012

    • Author(s)
      Mack JA, Feldman RJ, Itano N, Kimata K, Lauer M, Hascall VC, Maytin EV.
    • Journal Title

      J Invest Dermatol.

      Volume: 132 Issue: 1 Pages: 198-207

    • DOI

      10.1038/jid.2011.248

    • Related Report
      2012 Research-status Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Restriction of mast cell proliferation through hyaluronan synthesis by co-cultured fibroblasts.2012

    • Author(s)
      Takano H, Furuta K, Yamashita K, Sakanaka M, Itano N, Gohda E, Nakayama K, Kimata K, Sugimoto Y, Ichikawa A, Tanaka S
    • Journal Title

      Biol Pharm Bull

      Volume: 35 Pages: 408-12

    • NAID

      130001872324

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Inhibition of hyaluronan synthesis in breast cancer cells by4-Methylumbelliferone suppresses tumorigenicity in vitro and metastatic lesions of bone in vivo2012

    • Author(s)
      Urakawa H, Nishida Y, Wasa J, Arai E, Zhuo L, Kimata K, Kozawa E, Futamura N, Ishiguro N
    • Journal Title

      Int J Cancer

      Volume: 130(2) Issue: 2 Pages: 454-66

    • DOI

      10.1002/ijc.26014

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Inhibition of hyaluronan retention by4-methylumbelliferone suppresses osteosarcoma cells in vitro and lung metastasis in vivo2011

    • Author(s)
      Arai E, Nishida Y, Wasa J, Urakawa H, Zhuo L, Kimata K, Kozawa E, Futamura N, Ishiguro N
    • Journal Title

      Br J Cancer

      Volume: 105(12) Issue: 12 Pages: 1839-49

    • DOI

      10.1038/bjc.2011.459

    • Related Report
      2012 Research-status Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinicopathological Role of Serum-Derived Hyaluronan-Associated Protein (SHAP)-Hyaluronan Complex in Endometrial Cancer2011

    • Author(s)
      Yabushita H, Iwasaki K, Kanyama K, Obayashi Y, Zhuo L, Itano N, Kimata K, Wakatsuki A
    • Journal Title

      Obstet Gynecol Int

      Volume: 2011 Pages: 739150-739150

    • DOI

      10.1155/2011/739150

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Heparan sulfate 6-O-sulfotransferase 1, a gene involved in extracellular sugar modifications, is mutated in patients with idiopathic hypogonadotrophic hypogonadism2011

    • Author(s)
      Tornberg J, Sykiotis GP, Keefe K, Plummer L, Hoang X, Hall JE, Quinton R, Seminara SB, Hughes V, Van Vliet G, Van Uum S, Crowley WF, Habuchi H, Kimata K, Pitteloud N, Bülow HE
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 108 Issue: 28 Pages: 11524-9

    • DOI

      10.1073/pnas.1102284108

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Baculovirus envelope protein ODV-66 is a novel chondroitinase with distinct substrate specificity.2011

    • Author(s)
      Sugiura N, Setoyama Y, Chiba M, Kimata K, Watanabe H
    • Journal Title

      J Biol Chem

      Volume: 286 Issue: 33 Pages: 29026-29034

    • DOI

      10.1074/jbc.m111.251157

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Suzuki M, Imamura, T Sulfated glycosaminoglycans are required for specific and sensitive fibroblast growth factor (FGF) 19 signaling via FGF receptor 4 and betaKlotho2011

    • Author(s)
      Nakamura M, Uehara Y, Asada M, Honda E, Nagai,N, Kimata K
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 286 Issue: 30 Pages: 26418-26423

    • DOI

      10.1074/jbc.m111.251140

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Chondroitin sulfate N-acetylgalactosaminyltransferase 1 is necessary for normal endochondralossification and aggrecan metabolism.2011

    • Author(s)
      Sato T, Kudo T, Ikehara Y, Ogawa H, Hirano T, Kiyohara K, Hagiwara K, Togayachi A, Ema M, Takahashi S, Kimata K, Watanabe H, Narimatsu H
    • Journal Title

      J Biol Chem

      Volume: 286 Issue: 7 Pages: 5803-5812

    • DOI

      10.1074/jbc.m110.159244

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] ACUTE AND TEMPORAL EPRESSION OF TSG-6 IN MESENCHYMAL STEM CELLS CREATES HYALURONAN-RICH MICROENVIRONMENTS REQUIRED FOR THEIR SUCCESSFUL TRANSPLANTATION INTO THE MUSCLE TISSUES.2015

    • Author(s)
      2)Shigeko Torihashi, Mioko Ho, Yuji Kawakubo, Kazumi Komatsu, Masataka Nagai, Yuri Hirayama, Yuka Kawabata, Nana Takenaka-Ninagawa, Orawan Wanachewin, Lisheng Zhuo and Koji Kimata
    • Organizer
      HA2015
    • Place of Presentation
      Hilton Florence Metropole (Florence, Italy)
    • Year and Date
      2015-06-07 – 2015-06-11
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 損傷後の間葉系幹細胞による骨格筋肉組織の再生に必要な細胞微少環境2014

    • Author(s)
      木全弘治、鳥橋茂子、帆 澪子、川窪雄二、小松佳純、永井將貴、平山由梨、川端佑果、竹中-蜷川菜々、Orawan Wanachewin, 卓 麗聖、牛田享宏
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      国立京都国際会館(京都市左京区宝ヶ池)
    • Year and Date
      2014-10-15 – 2014-10-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] ヒアルロン酸合成阻害剤である4-methylunbelliferoneはコラーゲン誘発関節炎マウスの炎症と関節破壊を抑制する.2014

    • Author(s)
      吉岡裕、小澤英史、浦川浩、新井英介、二村尚久、卓麗聖、木全弘治、石黒直樹、西田佳弘
    • Organizer
      第27回日本軟骨代謝学会
    • Place of Presentation
      京都府医師会館
    • Related Report
      2013 Research-status Report
  • [Presentation] SHAPヒアルロン酸複合体は顕微鏡的多発血管炎における疾患活動性評価のsurrogate markerとなり得るか.2013

    • Author(s)
      河合浩寿、森田博之、北川渡、三浦直人、坂野章吾、菊地正悟、卓麗聖、木全弘治、今井裕一
    • Organizer
      第56回日本腎臓学会学術総会
    • Place of Presentation
      東京国際フォーラム
    • Related Report
      2013 Research-status Report 2012 Research-status Report
  • [Presentation] Heparan sulfate 6-O-sulfation – What we have learnt from the knockout mice2013

    • Author(s)
      Kimata K
    • Organizer
      The 20th PG forum
    • Place of Presentation
      Tokyo Medical and Dental University
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] ヒアルロン酸に共有結合する血清蛋白質、SHAPの機能と疾患との関連2013

    • Author(s)
      卓麗聖
    • Organizer
      神奈川科学技術アカデミー教育講座「糖鎖科学・糖鎖工学の基礎から応用」
    • Place of Presentation
      かながわサイエンスパーク、川崎市
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Heparan sulfate 6-O-sulfotransferase isoform-dependent regulatory effects of heparin on the activities of various proteases in mast cells and the biosynthesis of 6-O-sulfated heparin.2012

    • Author(s)
      Anower-E-Khuda MF, Habuchi H, Nagai N, Yokochi T, Habuchi O, Sugaya N, Kimata K.
    • Organizer
      Proteoglycans Gordon Research Conference
    • Place of Presentation
      Proctor Academy, Andover, NH, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Abnormal Heparan sulfate content in HME patient blood and the possible diagnostic application.2012

    • Author(s)
      Anower-E-Khuda MF, Habuchi H, Morita M, Yokochi T, Matsumoto K, Kimata K.
    • Organizer
      The 85th annual meeting of the Japanese Biochemical Society
    • Place of Presentation
      Marine Messe Fukuoka, Fukuoka, Japan
    • Related Report
      2012 Research-status Report
  • [Book] Covalent modification of hyaluronan by serum protein and its biological consequnce. In: Hyaluronan: Medical Uses, Biological Synthesis and Role in Wound Healing2014

    • Author(s)
      Zhuo L, Kimata K
    • Publisher
      Nova Science Publishers
    • Related Report
      2013 Research-status Report
  • [Book] 血清蛋白その他の生化学検査:ヒアルロン酸、内科(特集検査値を読む)2013

    • Author(s)
      卓麗聖、木全弘治
    • Total Pages
      6
    • Publisher
      南江堂
    • Related Report
      2013 Research-status Report
  • [Book] Handbook of Glycosyltransferases and Related Genes: Hyaluronan synthase 1-3 (HAS1-3)2013

    • Author(s)
      Itano N, Kimata K
    • Total Pages
      9
    • Publisher
      Springer
    • Related Report
      2012 Research-status Report
  • [Book] Handbook of Glycosyltransferases and Related Genes: Heparan-sulfate 6-O-sulfotransferase 1-3 (HS6ST1-3)2013

    • Author(s)
      Nagai N, Kimata K
    • Total Pages
      12
    • Publisher
      Springer
    • Related Report
      2012 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi