| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Research Abstract |
We found that unnecessary mRNA is not translated and segregated in P-bodies or stress granules (SGs) in yeast cells under stress conditions of alcoholic fermentation. We also demonstrated several data that indicate the contribution of P-bodies and SGs to effective and selective translation of mRNAs that are really required for the rapid stress response. Additionally, we isolated and characterized several mRNA that were preferentially translated under ethanol stress conditions. Furthermore, we verified that lactic acid can induce P-body formation and translational repression but not SG formation. Effects of acetic acid and propionic acid on mRNP granule formation were different from that of lactic acid.
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