Fungal silent secondary metabolite gene cluster activation by disturbance of environmental responses
| Project/Area Number |
23580125
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied microbiology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
MOTOYAMA Takayuki 独立行政法人理化学研究所, 長田抗生物質研究室, 専任研究員 (70291094)
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| Co-Investigator(Kenkyū-buntansha) |
HIROTA Hiroshi 理化学研究所, 理研-KRIBB連携研究ユニット, 客員研究員 (00126153)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | イネいもち病菌 / 天然化合物 / シグナル伝達 / 生合成 / 農薬 |
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| Outline of Final Research Achievements |
By disturbance of the signal transduction systems for environmental signals, we have enabled induced production of nectriapyrones and tenuazonic acid in the rice blast fungus. In contrast, epigenetic control compounds could not cause induced production of these secondary metabolites. We found that the induced production of tenuazonic acid is caused via a LaeA ortholog, a global regulator of fungal secondary metabolism. We have succeeded in identifying the biosynthetic gene for nectriapyrones and tenuazonic acid and revealed that these compounds are not essential for infection of the rice blast fungus. Tenuazonic acid showed rice blast disease suppression activity.
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Report
(5 results)
Research Products
(29 results)
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[Journal Article] Effects of acivicin on growth, mycotoxin production and virulence of phytopathogenic fungi2014
Author(s)
Maeda, K., Nakajima, Y., Motoyama, T., Kitou, Y., Kosaki, T., Saito, T., Nishiuchi, T., Kanamaru, K., Osada, H., Kobayashi, T., Kimura, M.
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Journal Title
Letters in Applied Microbiology
Volume: 59
Issue: 4
Pages: 377-383
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Detection of oxygen addition peaks for terpendole E and related indole-diterpene alkaloids in a positive-mode ESI-MS2014
Author(s)
Hongo, Y., Nakamura, T., Takahashi, S., Motoyama, T., Hayashi, T., Hirota, H., Osada, H., and Koshino, H.
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Journal Title
Journal of Mass Spectrometry
Volume: 49
Issue: 12
Pages: 537-542
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Terpendole E and its derivative inhibit STLC - and GSK-1-resistant Eg52014
Author(s)
Tarui Y, Chinen T, Nagumo Y, Motoyama T, Hayashi T, Hirota H, Muroi M, Ishii Y, Kondo H, Osada H, Usui T.
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Journal Title
ChemBioChem
Volume: (In press)
Issue: 7
Pages: 934-938
DOI
Related Report
Peer Reviewed
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[Journal Article] Identification and Characterization of an Inhibitor of Trichothecene 3-<i>O</i>-Acetyltransferase, TRI101, by the Chemical Array Approach2013
Author(s)
Nakajima Y, Kawamura T, Maeda K, Ichikawa H, Motoyama T, Kondoh Y, Saito T, Kobayashi T, Yoshida M, Osada H, Kimura M
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Journal Title
Bioscience, Biotechnology, and Biochemistry
Volume: 77
Issue: 9
Pages: 1958-1960
DOI
NAID
ISSN
0916-8451, 1347-6947
Related Report
Peer Reviewed
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