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Establishment of an antigen-specific immune regulating method by using food antigens

Research Project

Project/Area Number 23580159
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Food science
Research InstitutionTokyo University of Agriculture and Technology

Principal Investigator

YOSHIDA Tadashi  東京農工大学, (連合)農学研究科(研究院), 准教授 (20302911)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords免疫寛容 / T細胞アナジー / トランスクリプトーム解析 / 経口免疫寛容 / アレルギー / DNAメチル化解析
Research Abstract

The aim of this study is to understand the mechanism of hyposensitization therapy for allergic diseases. Our results showed that the balance of Ca2+ signal and JNK signal in T cells would determine whether activation or tolerization was induced to the T cells. We actually demonstrated that the altered balance of those signals which was made by inhibitors induced activation or tolerization depending on the concentration of the inhibitors, indicating that we can regulate the induction of T cell tolerance and activation arbitrary. Furthermore, we identified the genes which distinctly expressed in tolerized T cells comprehensively by transcriptome analysis using next generation DNA sequencer. Some of the genes were also up-regulated just after the stimulation which induces tolerance to T cells. These findings contribute to establish the safe and certain method for inducing immune tolerance.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (12 results)

All 2014 2013 2012 2011 Other

All Presentation (12 results) (of which Invited: 1 results)

  • [Presentation] 次世代シーケンサーを用いたアナジー化T細胞で発現が変動する遺伝子の網羅的解析2014

    • Author(s)
      吉岡雄介,古崎利紀,石井一夫,服部誠,好田正
    • Organizer
      日本農芸化学会
    • Place of Presentation
      東京
    • Year and Date
      2014-03-28
    • Related Report
      2013 Final Research Report
  • [Presentation] 食品アレルギー予防ワクチンへ向けて2014

    • Author(s)
      好田正
    • Organizer
      日本農芸化学会関東支部例会
    • Place of Presentation
      東京
    • Year and Date
      2014-02-01
    • Related Report
      2013 Final Research Report
  • [Presentation] T細胞のアナジー化によって発現が変動する遺伝子のトランスクリプトーム解析2013

    • Author(s)
      吉岡雄介,好田正
    • Organizer
      日本食品免疫学会
    • Place of Presentation
      東京
    • Year and Date
      2013-10-17
    • Related Report
      2013 Final Research Report
  • [Presentation] T細胞アナジーにおけるユビキチン化タンパク質の分解の役割2013

    • Author(s)
      安達悠,水口洋平,中嶋暁子,山本愛,服部誠,好田正
    • Organizer
      日本農芸化学会
    • Place of Presentation
      仙台
    • Year and Date
      2013-03-26
    • Related Report
      2013 Final Research Report
  • [Presentation] T細胞の活性化とアナジー化の決定においてカルシウムシグナルとのバランスの一翼を担うシグナルの同定2012

    • Author(s)
      安達悠,服部誠,好田正
    • Organizer
      日本食品免疫学会
    • Place of Presentation
      東京
    • Year and Date
      2012-10-16
    • Related Report
      2013 Final Research Report
  • [Presentation] T細胞の活性化とアナジー化におけるMAPKシグナルの役割2011

    • Author(s)
      安達悠,服部誠,好田正
    • Organizer
      日本食品免疫学会
    • Place of Presentation
      東京
    • Year and Date
      2011-10-18
    • Related Report
      2013 Final Research Report
  • [Presentation] T細胞のアナジー化によって発現が変動する遺伝子のトランスクリプトーム解析

    • Author(s)
      吉岡雄介,好田正
    • Organizer
      日本食品免疫学会
    • Place of Presentation
      東京,東京大学伊藤謝恩ホール
    • Related Report
      2013 Annual Research Report
  • [Presentation] 食品アレルギー予防ワクチンへ向けて

    • Author(s)
      好田正
    • Organizer
      日本農芸化学会関東支部例会
    • Place of Presentation
      東京,東京農工大学府中キャンパス
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 次世代シーケンサーを用いたアナジー化T細胞で発現が変動する遺伝子の網羅的解析

    • Author(s)
      吉岡雄介,古崎利紀,石井一夫,服部誠,好田正
    • Organizer
      日本農芸化学会
    • Place of Presentation
      東京,明治大学生田キャンパス
    • Related Report
      2013 Annual Research Report
  • [Presentation] T細胞の活性化とアナジー化の決定においてカルシウムシグナルとのバランスの一翼を担うシグナルの同定

    • Author(s)
      安達悠,服部誠,好田正
    • Organizer
      日本食品免疫学会
    • Place of Presentation
      東京,ヤクルトホール
    • Related Report
      2012 Research-status Report
  • [Presentation] T細胞アナジーにおけるユビキチン化タンパク質の分解の役割

    • Author(s)
      安達悠,水口洋平,中嶋暁子,山本愛,服部誠,好田正
    • Organizer
      日本農芸化学会
    • Place of Presentation
      仙台,東北大学川内キャンパス
    • Related Report
      2012 Research-status Report
  • [Presentation] T細胞の活性化とアナジー化におけるMAPKシグナルの役割

    • Author(s)
      安達悠,服部誠,好田正
    • Organizer
      日本食品免疫学会
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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