Establishment of an antigen-specific immune regulating method by using food antigens
| Project/Area Number |
23580159
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Tokyo University of Agriculture and Technology |
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Principal Investigator |
YOSHIDA Tadashi 東京農工大学, (連合)農学研究科(研究院), 准教授 (20302911)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 免疫寛容 / T細胞アナジー / トランスクリプトーム解析 / 経口免疫寛容 / アレルギー / DNAメチル化解析 |
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| Research Abstract |
The aim of this study is to understand the mechanism of hyposensitization therapy for allergic diseases. Our results showed that the balance of Ca2+ signal and JNK signal in T cells would determine whether activation or tolerization was induced to the T cells. We actually demonstrated that the altered balance of those signals which was made by inhibitors induced activation or tolerization depending on the concentration of the inhibitors, indicating that we can regulate the induction of T cell tolerance and activation arbitrary. Furthermore, we identified the genes which distinctly expressed in tolerized T cells comprehensively by transcriptome analysis using next generation DNA sequencer. Some of the genes were also up-regulated just after the stimulation which induces tolerance to T cells. These findings contribute to establish the safe and certain method for inducing immune tolerance.
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Report
(4 results)
Research Products
(12 results)
