Development of efficient gene markers that can be used to improve the fat deposition traits in pigs.
Project/Area Number |
23580393
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Applied animal science
|
Research Institution | Azabu University |
Principal Investigator |
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | ブタ / 改良 / 遺伝子マーカー / 脂肪蓄積 / グレリン / グレリン受容体 / レプチン受容体 / Gタンパク質共役型受容体120 / グレリン遺伝子 / グレリン受容体遺伝子 / レプチン受容体遺伝子 / 相関解析 / 経済形質 / 遺伝子多型マーカー / GPR120遺伝子 / 遺伝子多型 |
Research Abstract |
In the present study, we analyzed sequence variations in pig homolog of candidate genes for human obesity in order to develop efficient gene markers that can be used to improve the fat deposition traits in pigs. The preproghrelin (GHRL), growth hormone secretagogue receptor (GHSR), leptin receptor (LEPR), and G-protein coupled receptor 120 (GPR120) genes were selected to study. The c.335C>A polymorphism in GHRL gene was not associated with intra-muscular fat and back fat thickness. However, previously reported c.2002C>T (now c.1987C>T) polymorphism in LEPR was significantly associated with back fat thickness in our study population, and thus, we confirmed that this polymorphism could be an effective gene marker. Furthermore, we have succeeded in developing a simple genotyping method for this polymorphism.
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Report
(4 results)
Research Products
(1 results)
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[Journal Article] Evaluation of effects of multiple candidate genes (LEP, LEPR, MC4R, PIK3C3, and VRTN) on production traits in Duroc pigs2014
Author(s)
Hirose K, Ito T, Fukawa K, Arakawa A, Mikawa S, Hayashi Y, Tanaka K.
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Journal Title
Animal Science Journal
Volume: 85
Issue: 3
Pages: 198-206
DOI
Related Report