| Project/Area Number |
23580476
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied molecular and cellular biology
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| Research Institution | Nagasaki International University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 細胞老化 / TERT / p38 / 免疫老化 / 細胞老化関連遺伝子群 / マイクロアレイ / hTERT遺伝子 / EBV-B細胞 / shRNA |
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| Research Abstract |
Their functions genes were extracted by the comprehensive analysis of senescence-associated genes involved in immune senescence, Involved light chain antibody genes (19 genes), leukemia-related factors (gene 3), intestinal immune antibody production factor of (1 gene) has become a clear and heavy chain. As a group of genes that increase in expression, immunoglobulin heavy chain-related genes (4 genes), adipose tissue development-related factors (2 genes), nerve memory associated calmodulin-binding factor, histone cluster-related genes, LDL (low density lipoprotein) scavenger gene, involvement colorectal cancer metastasis-related factors, and the like of (each one gene) becomes clear, changes were observed in the group of genes a wide range that suggest possible the association between age-related disease.
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