| Project/Area Number |
23590034
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Tokushima Bunri University |
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Principal Investigator |
KAKU Hiroto 徳島文理大学, 薬学部, 准教授 (90299339)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
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| Keywords | 精密分子認識 / 包接錯体 / 光学分割 / テトラフェニレン誘導体 / デラセミ化 / フェネチルアミン類 / X線結晶解析 / フェネチルアミン / Ｘ線結晶解析 |
|---|
| Research Abstract |
Racemic 2,7,10,15-tetrahydroxytetraphenylene (THTP) was synthesized starting from 3-bromoanisole in 4 steps (overall yield 45%). Optical resolution of the racemic THTP was achieved by include complexation using (S)-phenethylamine to afford (-)-THTP, which could be used as a host molecule for optical resolution of racemic phenethylamine to (S)-phenethylamine. An X-ray crystallographic study elucidated that the host molecules THTP ingeniously included the guest molecule via hydrogen bonding and van der Waals interactions. Furthermore, the inclusion complex consisted of (-)-THTP, (S)-phenethylamine, and toluene in a 1 : 2 : 1 ratio, respectively.
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