| Project/Area Number |
23590037
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Microbial Chemistry Research Foundation |
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Principal Investigator |
WATANABE Takumi 公益財団法人微生物化学研究会, 微生物化学研究所 有機合成研究部, 主席研究員 (80270544)
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| Co-Investigator(Kenkyū-buntansha) |
SHIBASAKI Masakatsu (公財)微生物化学研究会, 微生物化学研 究所, 所長 (30112767)
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| Co-Investigator(Renkei-kenkyūsha) |
ABE Hikaru (公財)微生物化学研究会, 微生物化学研 究所 有機合成研究部, 研究員 (10462269)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 全合成 / 天然有機化合物 / 触媒的不斉反応 / 抗結核剤 / 有機化学 / 抗結核薬 |
|---|
| Research Abstract |
A study on catalytic asymmetric total synthesis of caprazamycin, an anti-TB antibiotic, was conducted. The synthesis would be applied to structure-activity relationship study on the related compounds.
To install the correct stereochemistries embedded in the structure of caprazamycin, catalytic enantioselective nitroaldol- and thioamide aldol reactions that have been recently reported from the laboratory, newly developed catalytic asymmetric alcoholysis of 3-methylglutaric anhydride, and diastereoselective isocyanoacetate aldol reaction were utilized. During course of the study, catalytic asymmetric total synthesis of caprazol was accomplished.
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