Formulation of novel functional dosage forms by spary congealing method.
| Project/Area Number |
23590047
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | University of Shizuoka |
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Principal Investigator |
ITAI Shigeru 静岡県立大学, 薬学部, 教授 (80453059)
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| Co-Investigator(Kenkyū-buntansha) |
IWAO Yasunori 静岡県立大学, 薬学部, 助教 (30433022)
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| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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|---|
| Keywords | 噴霧凝固造粒 / 放出制御 / 苦味マスキング / 大腸デリバリー / 微粒子設計 / 薬学 / 化学工学 / 材料加工・処理 / 設計工学 / 複合材料・物性 |
|---|
| Research Abstract |
By using spray congealing method, a taste masking technology with gastro-dissolvable polymer and low-melting-point material, a colon delivery system employing enteric polymer and low-melting-point material and a controlled release technology forming micropores dispersing sugars with various particle sizes were established. Furthermore, the optimization of formulation was carried out for each technology by applying multiple linear regression analysis. The spherical matrixes with optimum formula were manufactured by spray congealing method. As a result, each preparation exhibited intended release performance and both predictive and experimental data coincided with each other.
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Report
(4 results)
Research Products
(53 results)
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[Journal Article] Investigation of internal structure of fine granules by microtomography using synchrotron X-ray radiation2013
Author(s)
Noguchi, S., Kajihara, R., Iwao, Y., Fujinami, Y., Suzuki, Y., Terada, Y., Uesugi, K., Miura, K., Itai, S.
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Journal Title
Int. J. Pharm
Volume: 445
Pages: 93-98
Related Report
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[Journal Article] Investigation of internal structure of fine granules by microtomography using synchrotron X-ray radiation2013
Author(s)
Noguchi, S., Kajihara, R., Iwao, Y., Fujinami, Y., Suzuki, Y., Terada, Y., Uesugi, K., Miura, K., Itai, S.,
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Journal Title
Int. J. Pharm.
Volume: 445
Issue: 1-2
Pages: 93-98
DOI
Related Report
Peer Reviewed
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[Journal Article] Determination of Useful Ranges of Mixing Conditions for Glycerin Fatty Acid Ester by Multiple Regression Analysis2013
Author(s)
Uchimoto, T., Iwao, Y., Hattori, H., Noguchi, S., Itai, S.
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Journal Title
Chemical and Pharmaceutical Bulletin
Volume: 61
Issue: 11
Pages: 1143-1148
DOI
NAID
ISSN
0009-2363, 1347-5223
Related Report
Peer Reviewed
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[Journal Article] "Clarithromycin monohydrate: a synchrotron X-ray powder study,"2012
Author(s)
Noguchi, S., Fujiki, S., Iwao, Y., Miura, K., Itai, S.
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Journal Title
Acta Crystallographica Section E
Volume: 68
Pages: 667-668
Related Report
Peer Reviewed
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[Journal Article] "Structure of clarithromycin form I determined by synchrotron X-ray powder diffraction,"2012
Author(s)
Noguchi, S., Miura, K., Fujiki, S., Iwao, Y., Itai, S.,
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Journal Title
Acta Crystallographica Section C
Volume: 68
Pages: 41-44
Related Report
Peer Reviewed
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