| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
|---|
| Research Abstract |
A tablet database was created in order for designing tablet formulations based on the quality by design concept. The contribution of active ingredients (APIs) to tablet properties such as tensile strength and disintegration time was clarified. Before investigating effects of APIs, the tablet base formulation (placebo tablet) was optimized according to an expanded simplex search. The optimal placebo tablet showed sufficient hardness and rapid disintegration. Model tablets were prepared by incorporating each of 14 kinds of active ingredients into the optimal placebo tablet, and then examined the tablet properties, including tensile strength and disintegration time. Based on the experimental data, an ensemble artificial neural network incorporating general regression analysis was conducted. A reliable model of the correlation between the physicochemical properties of the active ingredients and the tablet properties was thus constructed.
|
