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Intracellular transport of phospholipids

Research Project

Project/Area Number 23590080
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Biological pharmacy
Research InstitutionKyushu University

Principal Investigator

KUGE Osamu  九州大学, 理学(系)研究科(研究院), 教授 (30177977)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords生体膜 / リン脂質 / 細胞生物学 / 細胞内輸送 / 酵母
Research Abstract

Intracellular transport of phospholipids is an essential event for the biogenesis of functional biological membranes. However, the transport processes are largely unknown with respect to mechanisms, genes and gene products involved. In this study I tried to identify novel genes involved in the phospholipids transport or phospholipid metabolism in yeast, and identified two genes that probably functioned in phospholipid transport to mitochondrial inner membrane, and one gene that was involved in the expression of a phospholipid metabolism gene, PSD2.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (24 results)

All 2014 2013 2012 2011 Other

All Journal Article (9 results) (of which Peer Reviewed: 7 results,  Acknowledgement Compliant: 1 results) Presentation (15 results) (of which Invited: 1 results)

  • [Journal Article] Involvement of Sac1 phosphoinositide phosphatase in the metabolism of phosphatidylserine in the yeast Saccharomyces cerevisiae.2014

    • Author(s)
      Tani M, Kuge O.
    • Journal Title

      Yeast

      Volume: 31 Issue: 4 Pages: 145-158

    • DOI

      10.1002/yea.3004

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] ミトコンドリアにおけるリン脂質の生合成医学のあゆみ2014

    • Author(s)
      久下理
    • Volume
      248
    • Pages
      1159-65
    • URL

      http://www.ishiyaku.co.jp/magazines/ayumi

    • Related Report
      2013 Final Research Report
  • [Journal Article] ミトコンドリアにおけるリン脂質の生合成2014

    • Author(s)
      久下 理
    • Journal Title

      医学のあゆみ

      Volume: 248 Pages: 1159-1165

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Tam41 is a CDP-diacylglycerol synthase required for cardiolipin biosynthesis in mitochondria2013

    • Author(s)
      Y. Tamura, Y. Harada, S. Nishikawa, K. Yamano, M. Kamiya, T. Shiota, T. Kuroda, O. Kuge, H. Sesaki, K. Imai, K. Tomii, and T. Endo
    • Journal Title

      Cell Metab.

      Volume: 17 Issue: 5 Pages: 709-718

    • DOI

      10.1016/j.cmet.2013.03.018

    • Related Report
      2013 Final Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Tam41 is a CDP-diacylglycerol synthase required for cardiolipin biosynthesis in mitochondria.2013

    • Author(s)
      Tamura Y, Harada Y, Nishikawa S, Yamano K, Kamiya M, Shiota T, Kuroda T, Kuge O, Sesaki H, Imai K, Tomii K, Endo T.
    • Journal Title

      Cell Metab.

      Volume: 印刷中

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Involvement of complex sphingolipids and phosphatidylserine in endosomal trafficking in yeast Saccharomyces cerevisiae.2012

    • Author(s)
      Tani M, Kuge O.
    • Journal Title

      Mol Microbiol.

      Volume: 86 Issue: 5 Pages: 1262-1280

    • DOI

      10.1111/mmi.12057

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Impaired retrograde membrane traffic through endosomes in a mutant CHO cell defective in phosphatidylserine synthesis2012

    • Author(s)
      Lee, S., Uchida1, Y., Emoto, K., Umeda, M., Kuge, O., Taguchi, T., Arai, H
    • Journal Title

      Genes to Cells

      Volume: 17 Issue: 8 Pages: 728

    • DOI

      10.1111/j.1365-2443.2012.01622.x

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hydroxylation state of fatty acid and long-chain base moieties of sphingolipid determine the sensitivity to growth inhibition due to AUR1 repression in Saccharomyces cerevisiae2012

    • Author(s)
      Tani M, Kuge O
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 417 Issue: 2 Pages: 673-678

    • DOI

      10.1016/j.bbrc.2011.11.138

    • NAID

      120005324445

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hydroxylation state of fatty acid and long-chain base moieties of sphingolipid determine the sensitivity to growth inhibition due to AUR1 repression in Saccharomyces cerevisiae2012

    • Author(s)
      Tani M, Kuge O.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 417 Pages: 673-678

    • NAID

      120005324445

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 酵母ホスホイノシチドホスファターゼSAC1欠損によるホスファチジルセリン量低下のメカニズム解析2013

    • Author(s)
      谷元洋, 久下理
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      横浜
    • Year and Date
      2013-09-11
    • Related Report
      2013 Final Research Report
  • [Presentation] 複合スフィンゴ脂質とホスファチジルセリンによるエンドソームリサイクリング経路の制御機構2012

    • Author(s)
      谷元洋, 久下理
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-15
    • Related Report
      2013 Final Research Report
  • [Presentation] 出芽酵母の生育阻害誘導に必要なセラミドの構造的要因の解析2012

    • Author(s)
      谷元洋, 久下理
    • Organizer
      日本脂質生化学会
    • Place of Presentation
      福岡
    • Year and Date
      2012-06-08
    • Related Report
      2013 Final Research Report
  • [Presentation] 酵母ホスファチジルセリン脱炭酸酵素2の活性発現に関与する新規遺伝子の同定と解析2012

    • Author(s)
      久下理、三好琢弥、山口剛典、谷元洋
    • Organizer
      日本脂質生化学会
    • Place of Presentation
      福岡
    • Year and Date
      2012-06-07
    • Related Report
      2013 Final Research Report
  • [Presentation] ミトコンドリア新規形態制御因子IAT1の解析2012

    • Author(s)
      友廣志穂、大橋順、前田敏孝、山本祐華、谷元洋、久下理
    • Organizer
      日本生化学会九州支部例会
    • Place of Presentation
      福岡
    • Year and Date
      2012-05-27
    • Related Report
      2013 Final Research Report
  • [Presentation] 出芽酵母のエンドソーム・ゴルジ間輸送における複合スフインゴ脂質とホスファチジルセリンの機能2011

    • Author(s)
      谷元洋, 久下理
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-22
    • Related Report
      2013 Final Research Report
  • [Presentation] 酵母ホスファチジルセリン脱炭酸酵素2の活性に関与する新規遺伝子(GIP3)の同定と解析2011

    • Author(s)
      三好琢弥、中嶋友博、谷元洋、久下理
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-22
    • Related Report
      2013 Final Research Report
  • [Presentation] リサイクリングエンドソームのホスファチジルセリンは逆行性膜輸送に必要である2011

    • Author(s)
      李尚憲、内田安則、久下理、田口友彦、新井洋由
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      国立京都国際会館
    • Related Report
      2011 Research-status Report
  • [Presentation] 出芽酵母のエンドソーム・ゴルジ間輸送における複合スフインゴ脂質とホスファチジルセリンの機能2011

    • Author(s)
      谷元洋、久下理
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      国立京都国際会館
    • Related Report
      2011 Research-status Report
  • [Presentation] 酵母ホスファチジルセリン脱炭酸酵素2の活性に関与する新規遺伝子(GIP3)の同定と解析2011

    • Author(s)
      三好琢弥、中嶋友博、谷元洋、久下理
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      国立京都国際会館
    • Related Report
      2011 Research-status Report
  • [Presentation] 酵母ホスホイノシチドホスファターゼSAC1欠損によるホスファチジルセリン量低下のメカニズム解析

    • Author(s)
      谷 元洋、久下 理
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] ミトコンドリア新規形態制御因子IAT1の解析

    • Author(s)
      友廣志穂、大橋順、前田敏孝、山本祐華、谷元洋、久下理
    • Organizer
      日本生化学会九州支部例会
    • Place of Presentation
      福岡大学(福岡市)
    • Related Report
      2012 Research-status Report
  • [Presentation] 酵母ホスファチジルセリン脱炭酸酵素2の活性発現に関与する新規遺伝子の同定と解析

    • Author(s)
      久下理、三好琢弥、山口剛典、谷元洋
    • Organizer
      日本脂質生化学会
    • Place of Presentation
      九州大学(福岡市)
    • Related Report
      2012 Research-status Report
  • [Presentation] 出芽酵母の生育阻害誘導に必要なセラミドの構造的要因の解析

    • Author(s)
      谷 元洋、久下 理
    • Organizer
      日本脂質生化学会
    • Place of Presentation
      九州大学(福岡市)
    • Related Report
      2012 Research-status Report
  • [Presentation] 複合スフィンゴ脂質とホスファチジルセリンによるエンドソームリサイクリング経路の制御機構

    • Author(s)
      谷 元洋、久下 理
    • Organizer
      日本生化学会大会
    • Place of Presentation
      九州大学(福岡市)
    • Related Report
      2012 Research-status Report
    • Invited

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Published: 2011-08-05   Modified: 2019-07-29  

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