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Novel functions, membrane receptor and mechanisms for angiostatin

Research Project

Project/Area Number 23590099
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Biological pharmacy
Research InstitutionMukogawa Women's University

Principal Investigator

TAKAHASHI Satoru  武庫川女子大学, 薬学部, 教授 (20268098)

Co-Investigator(Kenkyū-buntansha) SUGIYAMA Akinori  岩手医科大学, 薬学部, 准教授 (40260319)
SATO Keisuke  九州保健福祉大学, 薬学部, 教授 (00315293)
Co-Investigator(Renkei-kenkyūsha) SAKANAKA Mariko  武庫川女子大学, 薬学部, 助教 (00425109)
SHINYA Tomohiro  九州保健福祉大学, 薬学部, 助教 (60551299)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsアンギオスタチン / 血管新生 / 血管内皮細胞 / 受容体 / eNOS / COX-2
Research Abstract

We identified membrane protein p130 as a novel receptor for angiostatin (AS). Extracellular region of p130 including vWF-like domains binds AS. AS inhibited VEGF-induced NO production, COX-2 expression in vascular endothelial cells and migration of endothelial cells. We found that p130 might mediate such effects of AS. Our data suggest that AS impairs HSP90 association with eNOS, and that AS abrogates JNK activation. In addition, p130 forms a complex with VE-cadherin and beta-catenin in endothelial cells.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (13 results)

All 2014 2013 2012 2011 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (10 results)

  • [Journal Article] Recent advances in the study on resveratrol2012

    • Author(s)
      Rieko Nakata, Satoru Takahashi, Hiroyasu Inoue
    • Journal Title

      Biol. Pharm.Bull.

      Volume: 35 Pages: 273-279

    • NAID

      130001872306

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Repeated and long-term treatment with physiological concentrations of resveratrol promotes NO production in vascular endothelial cells2012

    • Author(s)
      Satoru Takahashi, Yukiko Nakashima
    • Journal Title

      Br. J.Nutr.

      Volume: 107 Issue: 6 Pages: 774-780

    • DOI

      10.1017/s0007114511003588

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] vascular endothelial growth factor (VEGF), VEGF receptors and their inhibitors for antiangiogenic tumor therapy2011

    • Author(s)
      Satoru Takahashi
    • Journal Title

      Biol. Pharm. Bull.

      Volume: 34 Pages: 1785-1788

    • NAID

      130001872596

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 血管内皮細胞の管腔形成におけるCRIM1の機能2014

    • Author(s)
      中島由希子、新屋智寛、秋山友希、佐藤圭創、高橋悟
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本市総合体育館
    • Related Report
      2013 Final Research Report
  • [Presentation] 血管新生抑制因子アンジオスタチンとフィブロネクチンの相互作用2014

    • Author(s)
      阪中麻利子、小倉有紀、中村まち、杉山晶則、高橋悟
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本市総合体育館
    • Related Report
      2013 Final Research Report
  • [Presentation] 血管新生抑制因子アンジオスタチンとフィブロネクチンの相互作用2014

    • Author(s)
      阪中麻利子、小倉有紀、中村まち、杉山晶則、高橋悟
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本市総合体育館
    • Related Report
      2013 Annual Research Report
  • [Presentation] 血管内皮細胞の管腔形成におけるCRIM1の機能2014

    • Author(s)
      中島由希子、新屋智寛、秋山友希、佐藤圭創、高橋悟
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本市総合体育館
    • Related Report
      2013 Annual Research Report
  • [Presentation] 血管内皮細胞の管腔形成におけるCRIM1の機能2013

    • Author(s)
      中島由希子、新屋智寛、秋山友希、戸田憲一、佐藤圭創、高橋悟
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2013 Final Research Report
  • [Presentation] CRIM1細胞内領域の血管内皮細胞における機能2013

    • Author(s)
      森本麻由佳、高橋悟
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2013 Final Research Report
  • [Presentation] CRIM1細胞内領域の血管内皮細胞における機能2013

    • Author(s)
      森本麻由佳、高橋悟
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2013 Annual Research Report
  • [Presentation] 血管内皮細胞の管腔形成におけるCRIM1の機能2013

    • Author(s)
      中島由希子、新屋智寛、秋山友希、戸田憲一、佐藤圭創、高橋悟
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2013 Annual Research Report
  • [Presentation] H2受容体遮断薬シメチジンの血管内皮細胞に対する作用2013

    • Author(s)
      阪中麻利子,岩田優紀子,小川真季,高橋悟
    • Organizer
      日本薬学会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] アンジオスタチンの血管内皮細胞への抑制作用におけるp38 MAPK、JNKの関与

    • Author(s)
      橋口誠子,新屋智寛,豊田紗子,東伸吾,南嘉信,佐藤圭創,高橋悟
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都市
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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