Mechanisms of neuronal-glial-vascular interactions in the retina and the application for development of anti-glaucoma drugs
| Project/Area Number |
23590112
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MORI Asami 北里大学, 薬学部, 助教 (80453504)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 薬理学 / 血管生物学 / 網膜神経 / グリア細胞 / 網膜血管 / 神経節細胞 |
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| Research Abstract |
This study aimed to clarify the mechanisms of neuronal-glial-vascular interactions in the retina using a rat model of retinal degeneration induced by an intravitreal injection of NMDA. In this model, loss of neuronal cells, accumulation of leukocytes, activation of microglia, and vascular injury were observed after NMDA treatment. Neuronal cell loss and microglia activation preceded vascular injury following NMDA treatment. Inhibitors of macrophage migration inhibitory factor (MIF) and mammalian target of rapamycin (mTOR) attenuated these NMDA-induced responses. Therefore, compounds acting on these molecules may have the potential to correct the neuronal-glial-vascular interaction and ultimately be used for the treatment of glaucoma.
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Report
(4 results)
Research Products
(23 results)
