Development of risk evaluation method for xenobiotics based on the interindividual differences of drug-metabolizing enzymes
| Project/Area Number |
23590148
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental pharmacy
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| Research Institution | Yokohama College of Pharmacy (2013)
Okayama University (2011-2012) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NARIMATSU Shizuo 岡山大学, 大学院医歯薬学総合研究科, 教授 (20113037)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 異物代謝酵素 / シトクロムP450 / UDP-グルクロン酸転移酵素 / フタル酸エステル類 / iPS細胞 / リスク評価法 / シトクロムP450（UGT） / UDP-グルクロン酸転移酵素（UGT） / フタル酸ビス(2-エチルヘキシル)（DEHP） / モノ(2-エチルヘキシル)フタレート（MEHP） / HepG2細胞 / シトクロムP450（CYP） / 転写制御因子（NR） / ヒト人工多能性幹細胞（iPS細胞） |
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| Research Abstract |
The purpose of this study was to develop risk evaluation method for environmental pollutants such as endocrine-disruptors and sick-building syndrome substances. The finding in this study suggest that diester phthalate hydrolysis activities in human liver microsomes depend on the chemical structure, and that the expression and inducibility of UGT in iPS cell-derived hepatocyte-like cells are similar that of human livers.
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Report
(4 results)
Research Products
(41 results)
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[Journal Article] Butylbenzyl phthalate hydrolysis in liver microsomes of humans, monkeys, dogs, rats and mice2014
Author(s)
Takahara Y, Kinashi Y, Takahara Y, Hichiya H, Okada K, Murata M, Shigeyama M, Hanioka N
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Journal Title
Biol Pharm Bull
Volume: 37
Pages: 703-706
NAID
Related Report
Peer Reviewed
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