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The action of IL-24 involving the exacerbation of pneumonia in RSV-infected mice exposed perinatally to a brominated flame retardant.

Research Project

Project/Area Number 23590161
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Environmental pharmacy
Research InstitutionKyushu University of Health and Welfare

Principal Investigator

WATANABE Wataru  九州保健福祉大学, 薬学部, 教授 (50399218)

Co-Investigator(Kenkyū-buntansha) KUROKAWA Masahiko  九州保健福祉大学, 大学院医療薬学研究科, 教授 (80186527)
YOSHIDA Hiroki  九州保健福祉大学, 大学院医療薬学研究科, 講師 (90469411)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsRSV / IL-24 / 臭素化難燃剤 / TBBPA / ウイルス / 免疫学 / 有害化学物質 / RSウイルス
Research Abstract

To reveal effects of perinatal exposure to a brominated flame retardant TBBPA on the exacerbation of RSV-induced pneumonia, mechanism of action of IL-24 on RSV infection was investigated.
By immune histopathological analysis, increase of the expression of IL-24 was confirmed in the lung tissues of RSV-infected mice exposed perinatally to TBBPA. The expression of IL-24 was also found in RA264.7 cells by real-time RT-PCR and western blotting in vitro. Although correlation between increase of IL-24 and decrease of a proinflammatory cytokine TNF-alpha was observed in the RSV-infected cells, direct interaction of them could not be revealed due to the failure of RNAi against IL-24 gene. Increase of IL-24 induced due to TBBPA-exposure might affect the production of proinflammatory cytokine from macrophages, should result in disorder of immune system responding to RSV infection.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (34 results)

All 2014 2013 2012 2011 Other

All Journal Article (14 results) (of which Peer Reviewed: 14 results) Presentation (14 results) (of which Invited: 1 results) Book (3 results) Remarks (3 results)

  • [Journal Article] Perinatal exposure to insecticide methamidophos suppressed production of proinflammatory cytokines responding to virus infection in lung tissues in mice.2013

    • Author(s)
      Watanabe,W., Yoshida, H., Hirose, A., Akashi, T., Takeshita, T., Kuroki, N., Shibata, A., Hongo, S., Hashiguchi, S., Konno, K., Kurokawa, M.
    • Journal Title

      BioMed. Res. Int.

      Volume: 0 Pages: 151807-151814

    • DOI

      10.1155/2013/151807

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of Brazilian propolis on exacerbation of respiratory syncytial virus infection in mice exposed to tetrabromobisphenol A, a brominated flame retardant.2013

    • Author(s)
      Takeshita, T., Watanabe, W., Toyama, S., Hayashi, Y., Honda, S., Sakamoto, S., Matsuoka, S., Yoshida, H., Takeda, S., Hidaka, M., Tsutsumi, S., Yasukawa, K., Park, Y.K., Kurokawa, M.
    • Journal Title

      Evid.-Based Compl. Alt. Med.

      Volume: 0 Pages: 698206-698212

    • DOI

      10.1155/2013/698206

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of oral administration of probiotics from Mongolian dairy products on Th1 immune response in mice2013

    • Author(s)
      Takeda, S., Kawahara, S., Hidaka, M., Yoshida, H., Watanabe, W., Takeshita, M., Kikuchi, Y., Bumbein, D., Muguruma, M., Kurokawa, M
    • Journal Title

      Biosci. Biotechnol. Biochem

      Volume: 77 Pages: 1372-1378

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Citrus flavonoid naringenin inhibits TLR2 expression in adipocytes2013

    • Author(s)
      Yoshida, H., Watanabe, W., Oomagari, H., Tsuruta, E., Shida, M., Kurokawa, M
    • Journal Title

      J. Nutr. Biochem

      Volume: 24 Pages: 1276-1284

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Corticosteroids plus long-acting beta2-agonists prevent double-stranded RNA-induced upregulation of B7-H1 on airway epithelium2013

    • Author(s)
      Kan-o, K., Matsumoto, K., Inoue, H., Fukuyama, S., Asai, Y., Watanabe, W., Kurokawa, M., Araya, J., Kuwano, K., Natanishi, Y
    • Journal Title

      Int. Arch. Allergy Immunol

      Volume: 160 Pages: 27-36

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of oral administration of probiotics from Mongolian dairy products on Th1 immune response in mice.2013

    • Author(s)
      Takeda, S., Kawahara, S., Hidaka, M., Yoshida, H., Watanabe, W., Takeshita, M., Kikuchi, Y., Bumbein, D., Muguruma, M., Kurokawa, M.
    • Journal Title

      Biosci. Biotechnol. Biochem.

      Volume: 77 Pages: 1372-1378

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antiviral activity of diarylheptanoid stereoisomers against respiratory syncytial virus in vitro and in vivo.2013

    • Author(s)
      Konno, K., Miura, M., Toriyama, M., Motohashi, S., Sawamura, R., Watanabe, W., Yoshida, H., Kato, M., Yamamoto, R., Yasukawa, K., Kurokawa, M.
    • Journal Title

      J. Nat. Med.

      Volume: -

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Citrus flavonoid naringenin inhibits TLR2 expression in adipocytes.2013

    • Author(s)
      Yoshida, H., Watanabe, W., Oomagari, H., Tsuruta, E., Shida, M., Kurokawa, M.
    • Journal Title

      J. Nutr. Biochem.

      Volume: -

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Corticosteroids plus long-acting beta2-agonists prevent double-stranded RNA-induced upregulation of B7-H1 on airway epithelium.2013

    • Author(s)
      Kan-o, K., Matsumoto, K., Inoue, H., Fukuyama, S., Asai, Y., Watanabe, W., Kurokawa, M., Araya, J., Kuwano, K., Natanishi, Y.
    • Journal Title

      Int. Arch. Allergy Immunol.

      Volume: 160 Pages: 27-36

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Antiviral activities of diarylheptanoids isolated from Alpinia officinarum against respiratory syncytial virus, poliovirus, measles virus and herpes simplex virus type 1 in vitro2012

    • Author(s)
      Konno, K., Sawamura, R., Sun, Y., Yasukawa, K., Shimizu, T., Watanabe, W., Kato, M., Yamamoto, R., Kurokawa, M
    • Journal Title

      Nat. Prod. Commun

      Volume: 6 Pages: 1881-1884

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy of oral administration of heat-killed probiotics from Mongolian dairy products against influenza infection in mice : Alleviation of influenza infection by its immunomodulatory activity through intestinal immunity2011

    • Author(s)
      Takeda, S. Takeshita, M., Kikuchi, Y., Dashnyam, B., Kawahara, S., Yoshida, H., Watanabe, W., Muguruma, M., Kurokawa, M
    • Journal Title

      Int. Immunopharmacol

      Volume: 11 Pages: 1976-1983

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Antiviral activities of diarylheptanoids isolated from Alpinia officinarum against respiratory syncytial virus, poliovirus, measles virus and herpes simplex virus type 1 in vitro.2011

    • Author(s)
      Konno, K., Sawamura, R., Sun, Y., Yasukawa, K., Shimizu, T., Watanabe, W., Kato, M., Yamamoto, R., Kurokawa, M.
    • Journal Title

      Nat. Prod. Commun.

      Volume: 6 Pages: 1881-1884

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Efficacy of Korean traditional medicines against influenza virus infection in mice and their modes of anti-influenza virus action2011

    • Author(s)
      Shimizu, T., Sawamura, R., Kim, K-H., Kim, K-H., Lee, S-H., Lee, Y-S., Kim, T-G., Kai, H., Yoshida, H., Watanabe, W., Matsuno, K., Shiraki, K., Kurokawa, M.
    • Journal Title

      J. Trad. Med.

      Volume: 28 Pages: 115-127

    • NAID

      130004495573

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Efficacy of oral administration of heat-killed probiotics from Mongolian dairy products against influenza infection in mice: Alleviation of influenza infection by its immunomodulatory activity through intestinal immunity.2011

    • Author(s)
      Takeda, S. Takeshita, M., Kikuchi, Y., Dashnyam, B., Kawahara, S., Yoshida, H., Watanabe, W., Muguruma, M., Kurokawa,
    • Journal Title

      Int. Immunopharmacol.

      Volume: 11 Pages: 1976-1983

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 多層型カーボンナノチューブ曝露によるRSウイルス感染免疫への影響2014

    • Author(s)
      橋口誠子、吉田裕樹、徳田健治、紺野克彦、明石敏、広瀬明彦、黒川昌彦、渡辺渡
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本、ポスター28pmS-064
    • Year and Date
      2014-02-28
    • Related Report
      2013 Final Research Report
  • [Presentation] Perinatal exposure to an insecticide methamidophos affected the immune redponse to virus infection in the next generation of mice2013

    • Author(s)
      Wataru Watanabe, Hiroki Yoshida, Akihiko Hirose, Masahiko Kurokawa
    • Organizer
      EUROTOX2013
    • Place of Presentation
      Interlaken, Switzerland, poster P11-15
    • Year and Date
      2013-09-02
    • Related Report
      2013 Final Research Report
  • [Presentation] 有機リン系殺虫剤メタミドホスの周産期曝露によるRSウイルス感染免疫への影響2013

    • Author(s)
      渡辺渡、吉田裕樹、広瀬明彦、黒木奈緒、本郷聡子、紺野克彦、黒川昌彦
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜、ポスター30pmE-205
    • Year and Date
      2013-03-30
    • Related Report
      2013 Final Research Report
  • [Presentation] Effects of nanoparticles of titanium dioxide on the immune redponse to virus infection2012

    • Author(s)
      Wataru Watanabe, Hiroki Yoshida, Akihiko Hirose, Katsuhiko Konno, Masahiko Kurokawa
    • Organizer
      EUROTOX2012
    • Place of Presentation
      Stockholm, Sweden, poster P20-02
    • Year and Date
      2012-06-19
    • Related Report
      2013 Final Research Report
  • [Presentation] 酸化チタンナノ粒子のマクロファージおよびマウスモデルにおけるRSウイルス感染免疫応答における影響2012

    • Author(s)
      渡辺渡,吉田裕樹,広瀬明彦, 紺野克彦, 山中沙代子, 黒木奈緒, 黒川昌彦
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Related Report
      2013 Final Research Report
  • [Presentation] Effects of the nanoparticles of titanium dioxide on the immune response to respiratory syncytial virus (RSV) infection in macrophages in vitro and mouse model in vivo2011

    • Author(s)
      Watanabe, W., Yoshida, H., Hirose, A., Konno, K., Kurokawa, M
    • Organizer
      International Congress of Virology
    • Place of Presentation
      Sapporo
    • Related Report
      2013 Final Research Report
  • [Presentation] Efficacy of Brazilian propolis against herpes simplex virus type 1 infection in mice and their modes of anti-herpetic efficacies2011

    • Author(s)
      Yoshida1, H., Kai, H., Tsutsumi, S, Yasukawa, K., Matsuno, K., Watanabe, W., Shiraki, K., Kurokawa, M
    • Organizer
      International Congress of Virology
    • Place of Presentation
      Sapporo
    • Related Report
      2013 Final Research Report
  • [Presentation] RSウイルス感染マウスモデルを用いた臭素化難燃物質の発達期免疫毒性の評価「発達期免疫毒性(developmental immunotoxicity)の評価方法」2011

    • Author(s)
      渡辺渡
    • Organizer
      第18回日本免疫毒性学会学術大会
    • Place of Presentation
      千葉
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Effects of the nanoparticles of titanium dioxide on the immune response to respiratory syncytial virus (RSV) infection in macrophages in vitro and mouse model in vivo.2011

    • Author(s)
      Watanabe, W., Yoshida, H., Hirose, A., Konno, K., Kurokawa, M
    • Organizer
      International Congress of Virology 2011
    • Place of Presentation
      Sapporo
    • Related Report
      2011 Research-status Report
  • [Presentation] ウイルス感染マウスモデルを用いた臭素化難燃物質の発達期免疫毒性の評価,試験法ワークショップ「発達期免疫毒性(developmental immunotoxicity)の評価方法」2011

    • Author(s)
      渡辺 渡
    • Organizer
      第18回日本免疫毒性学会学術大会(招待講演)
    • Place of Presentation
      千葉
    • Related Report
      2011 Research-status Report
  • [Presentation] 多層型カーボンナノチューブ曝露によるRSウイルス感染免疫への影響

    • Author(s)
      橋口誠子、吉田裕樹、徳田健治、紺野克彦、明石 敏、広瀬明彦、黒川昌彦、渡辺 渡
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本(市民体育館)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Perinatal exposure to an insecticide methamidophos affected the immune redponse to virus infection in the next generation of mice.

    • Author(s)
      Wataru Watanabe, Hiroki Yoshida, Akihiko Hirose, Masahiko Kurokawa
    • Organizer
      EUROTOX2013
    • Place of Presentation
      スイス(インターラーケン国際会議場)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Effects of nanoparticles of titinium dioxide on the immune response to virus infection.

    • Author(s)
      Watanabe, W., Yoshida, H., Hirose, A., Konno, K., Kurokawa, M.
    • Organizer
      EuroTox2012
    • Place of Presentation
      Stockholm, Sweden
    • Related Report
      2012 Research-status Report
  • [Presentation] 有機リン系殺虫剤メタミドホスの周産期暴露によるRSウイルス感染免疫への影響

    • Author(s)
      渡辺 渡, 吉田裕樹,広瀬明彦,黒木奈緒,本郷聡子,柴田麻美, 紺野克彦, 黒川昌彦
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Book] 薬学領域の食品衛生化学2013

    • Author(s)
      渡辺渡(分担), 編集長澤一樹、川崎直人
    • Publisher
      廣川書店
    • Related Report
      2013 Final Research Report
  • [Book] 薬学領域の生化学"第12章遺伝子工学の基礎"2013

    • Author(s)
      黒川昌彦(分担), 編集伊藤晃
    • Publisher
      廣川書店
    • Related Report
      2013 Final Research Report
  • [Book] 薬学領域の食品衛生化学2013

    • Author(s)
      川崎直人、田村悦臣、長岡寛明、長澤一樹、渡辺 渡
    • Total Pages
      248
    • Publisher
      廣川書店
    • Related Report
      2012 Research-status Report
  • [Remarks] 研究室HP

    • URL

      http://biochem-kuhw.org/

    • Related Report
      2013 Final Research Report
  • [Remarks] 九州保健福祉大学薬学部生化学講座・微生物学研究室

    • URL

      http://biochem-kuhw.org/

    • Related Report
      2013 Annual Research Report
  • [Remarks] 九州保健福祉大学薬学部薬学科 微生物学研究室ホームページ

    • URL

      http://biochem-kuhw.org/

    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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