• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Clarifying about the variation factors of the pharmacokinetics of doxapram in low-birthweight infants.

Research Project

Project/Area Number 23590189
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Medical pharmacy
Research InstitutionDaiichi University, College of Pharmaceutical Sciences (2013)
Kumamoto University (2011-2012)

Principal Investigator

IRIKURA Mitsuru  第一薬科大学, 薬学部, 教授 (70151694)

Co-Investigator(Kenkyū-buntansha) 入江 徹美  熊本大学, 生命科学研究部, 教授 (60150546)
山﨑 俊夫 (山崎 俊夫)  藤田保健衛生大学, 医学部, 教授 (40135364)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywordsドキサプラム / 未熟児無呼吸発作 / 母集団薬物動態解析 / 至適投与方法 / 低出生体重児無呼吸発作
Research Abstract

This study aimed to determine the population pharmacokinetics of doxapram in low birth weight infants. A total of 92 serum concentration measurements obtained from 34 Japanese neonates were analyzed using nonlinear mixed-effect modeling (NONMEM). Estimates generated by NONMEM indicated that clearance of doxapram (CL; L/kg/h) was influenced by postmenstrual age (PMA; weeks), body weight (BW; g), and aspartate aminotransferase (AST; IU/L). In addition, the volume of distribution (Vd; L/kg) was influenced by gestational age (GA; weeks). The final pharmacokinetic model was: CL = BW/PMA x 0.0453 x serum AST -0.373; Vd = 2.54 (if GA >28 weeks) and Vd = 2.54 x 2.11 (if GA ≤ 28 weeks). The interindividual variabilities in CL and Vd were 39.9% and 83.0%, respectively, and the residual variability was 20.9%.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (7 results)

All 2013 2012 2011

All Journal Article (1 results) Presentation (6 results)

  • [Journal Article] 低出生体重児の無呼吸発作治療を目的とした低用量ドキサプラムの投与設計低出生体重児の無呼吸発作治療を目的とした低用量ドキサプラムの投与設計2013

    • Author(s)
      小川由貴, 入倉 充, 冨安麻友, 瓜生真実子, 石塚洋一, 近藤悠希, 山﨑俊夫, 湯川栄二, 入江徹美
    • Journal Title

      日本小児臨床薬理学会雑誌

      Volume: 26 (1) Pages: 97-101

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 低出生体重児におけるドキサプラムの母集団動態解析および有効血清中濃度の検討2012

    • Author(s)
      小川由貴,入倉充,小原優佳,河内山佳英,湯川榮二,山崎俊夫,石塚洋一,入江徹美
    • Organizer
      医療薬学フォーラム2012第20回クリニカルファーマシーシンポジウム
    • Place of Presentation
      福岡市
    • Related Report
      2013 Final Research Report
  • [Presentation] 低出生体重児におけるドキサプラムの母集団薬物動態解析およびその有効血清中濃度2012

    • Author(s)
      小川由貴,入倉充,山崎俊夫,川瀬昭彦,近藤裕一,入江徹美
    • Organizer
      第57回日本未熟児新生児学会・学術集会
    • Place of Presentation
      熊本市
    • Related Report
      2013 Final Research Report
  • [Presentation] 低出生体重児におけるドキサプラムの母集団動態解析および有効血清中濃度の検討2012

    • Author(s)
      小川由貴,入倉 充,小原優佳,河内山佳英,湯川榮二,山崎俊夫,石塚洋一,入江徹美
    • Organizer
      第20回クリニカルファーマシーシンポジウム
    • Place of Presentation
      福岡国際会議場,福岡市
    • Related Report
      2012 Research-status Report
  • [Presentation] 低出生体重児におけるドキサプラムの母集団薬物動態解析およびその有効血清中濃度2012

    • Author(s)
      小川由貴,入倉充,山崎俊夫,川瀬昭彦,近藤裕一,入江徹美・
    • Organizer
      第57回日本未熟児新生児学会・学術集会
    • Place of Presentation
      ホテル日航熊本,熊本市
    • Related Report
      2012 Research-status Report
  • [Presentation] 低出生体重児における低用量ドキサプラムの体内動態解析2011

    • Author(s)
      入倉充、湯川榮二、山﨑俊夫、石塚洋一、入江徹美
    • Organizer
      第38回日本小児臨床薬理学会
    • Place of Presentation
      大津市
    • Related Report
      2013 Final Research Report
  • [Presentation] 低出生体重児におけるドキサプラムの母集団薬物動態解析2011

    • Author(s)
      小原優佳, 河内山佳英, 湯川榮二, 山崎俊夫, 石塚洋一, 入倉充, 入江徹美
    • Organizer
      第28回日本薬学会九州支部大会
    • Place of Presentation
      福岡市
    • Related Report
      2013 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi