Role of AMP kinase in cellular proliferation and polarity in the gastrointestinal tract

• Project/Area Number: 23590272
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General physiology
• Research Institution: Research Institute, International Medical Center of Japan
• Principal Investigator: INAGAKI-OHARA Kyoko 独立行政法人国立国際医療研究センター, その他部局等, その他 (70363588)
• Co-Investigator(Renkei-kenkyūsha): MIHONOSHI Yasuhiko (10200099)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: AMPK / 胃 / レプチンシグナル / レプチン / 消化管 / 高脂肪食 / 極性 / 免疫

Research Abstract

AMPK, a critical molecule in leptin receptor signaling is not only an essential factor for regulation of metabolic energy balance at the whole-body level but also affects cellular proliferation.However, it remains unknown the pathophysiological role of leptin in gastrointestinal tract. We show the relevance of AMPK phosphorylation for the progression of atrophic gastritis due to a high-fat diet feeding. SInce destruction of tissue construction and metabolic energy alteration is one of oncogenic feature, it is conceivable that the effect of AMPK phosphorylation on progression of atrophic gastritis.

Research Products

• [Journal Article] Enhancement of leptin receptor signaling by SOCS3 deficiency induces development of gastric tumors in mice (2014)
  • Author(s): Inagaki-Ohara K, Mayuzumi H, Kato S, Minokoshi Y, Otsubo T, Kawamura YI, Dohi T, Matsuzaki G, Yoshimura A
  • Journal Title: Oncogene Volume: 33(1) Pages: 74-84
  • Peer Reviewed
• [Journal Article] Enhancement of leptin receptor signaling by SOCS3 deficiency induces development of gastric tumors in mice. (2014)
  • Author(s): Inagaki-Ohara K, Mayuzumi H, Kato S, Minokoshi Y, Otsubo T, Kawamura YI, Dohi T, Matsuzaki G, Yoshimura A.
  • Journal Title: Oncogene Volume: 33 Issue: 1 Pages: 74-84
  • DOI: 10.1038/onc.2012.540
  • Peer Reviewed / Open Access
• [Journal Article] SOCS, inflammation, and cancer (2013)
  • Author(s): Inagaki-Ohara K, Kondo T, Ito M, Yoshimura A
  • Journal Title: JAKSTAT Volume: 1;2(3)
  • Peer Reviewed
• [Journal Article] SOCS, inflammation and cancer (2013)
  • Author(s): Inagaki-Ohara K, Kondo T, Ito M., Yoshimura A.
  • Journal Title: JAK-STAT Volume: 2:3
  • Peer Reviewed
• [Journal Article] Adrenomedullin is a potential therapeutic agent for inflammatory bowel diseases. (2013)
  • Author(s): Ashizuka S., Inatsu H., Inagaki-Ohara K., Kita T., Kitamura K.
  • Journal Title: Current Protein & Peptide Science Volume: in press
  • Peer Reviewed
• [Journal Article] Microbiota-derived lactate accelerates colon epithelial cell turnover in starvation-refed mice (2013)
  • Author(s): Okada T
  • Journal Title: Nat. Commun Volume: 4巻 Issue: 1 Pages: 1654-1654
  • DOI: 10.1038/ncomms2668
  • Peer Reviewed
• [Presentation] Leptin receptor signaling pathways is required for high-fat diet-induced atrophic gastritis in mice (2014)
  • Author(s): Kyoko Inagaki-Ohara, Shiki Okamoto, Yasuhiko Minokoshi
  • Organizer: 第91回日本生理学会大会公募シンポジウム
  • Place of Presentation: 鹿児島大学,鹿児島県
  • Year and Date: 2014-03-17
• [Presentation] High-fat diet-induced atrophic gastritis requires leptin receptor signaling pathways in mice (2014)
  • Author(s): Kyoko Inagaki-Ohara, Shiki Okamoto, Yasuhiko Minokoshi
  • Organizer: Keystone Symposia
  • Place of Presentation: Fairmont Hotel Vancouver, Vancouver, Canada
  • Year and Date: 2014-01-14
• [Presentation] Augmentation of leptin receptor signaling by loss of SOCS3 induces development of gastric tumors in mice.Augmentation of leptin receptor signaling by loss of SOCS3 induces development of gastric tumors in mice (2013)
  • Author(s): Kyoko Inagaki-Ohara, Yasuhiko Minokoshi, Seiya Kato, Taeko Dohi, Goro Matsuzaki, Akihiko Yoshimura
  • Organizer: American Diabetes Association 73^<rd> Scientific sessions
  • Place of Presentation: McCormick Place Convention Center. Chicago, USA
  • Year and Date: 2013-06-23
• [Presentation] 高脂肪食摂取による消化管粘膜細胞機能に及ぼす影響 (2013)
  • Author(s): 稲垣匡子, 岡本士毅, 土肥多恵子, 箕越靖彦
  • Organizer: 第67回日本栄養食糧学会大会
  • Place of Presentation: 名古屋大学,愛知県
  • Year and Date: 2013-05-25
• [Presentation] Enhancement of leptin receptor signaling by SOCS3 deficiency induces development of gastric tumors in mice (2012)
  • Author(s): Kyoko Inagaki-Ohara, Seiya Kato, Yasuhiko Minokoshi, Taeko Dohi, Goro Matsuzaki Akihiko Yoshimura
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-11
• [Presentation] 消化管上皮細胞特異的SOCS3欠損マウスの胃腫瘍発症におけるレプチン/レプチン受容体の役割 (2012)
  • Author(s): 稲垣匡子, 箕越靖彦, 土肥多恵子, 松崎吾朗, 加藤誠也, 吉村昭彦
  • Organizer: 第66回日本栄養食糧学会大会
  • Place of Presentation: 東北大学, 宮城県
  • Year and Date: 2012-05-19
• [Presentation] 消化管上皮細胞特異的SOCS3欠損マウスの胃腫瘍発症におけるレプチン／レプチン受容体の役割 (2012)
  • Author(s): 稲垣匡子、箕越靖彦、土肥多惠子、松崎吾朗、加藤誠也、吉村昭彦
  • Organizer: 第６６回日本栄養食糧学会
  • Place of Presentation: 東北大学
• [Presentation] SOCS3 欠損によるレプチンシグナルの亢進は胃癌を誘導する (2012)
  • Author(s): 稲垣 匡子, 加藤 誠也, 箕越 靖彦,土肥 多恵子, 松崎 吾朗, 吉村 昭彦
  • Organizer: 第35 回日本分子生物学会
  • Place of Presentation: 岡国際会議場・マリンメッセ福岡
• [Presentation] High-fat diet-induced atrophic gastritis requires leptin receptor signalingpathways in mice
  • Author(s): Kyoko Inagaki-Ohara, Shiki Okamoto, Yasuhiko Minokoshi.
  • Organizer: 生理学会（公募シンポジウム）
  • Place of Presentation: 鹿児島
• [Presentation] High-fat diet-induced atrophic gastritis requires leptin receptor signaling pathways in mice
  • Author(s): Kyoko Inagaki-Ohara, Shiki Okamoto, Yasuhiko Minokoshi.
  • Organizer: Keystone Symposia
  • Place of Presentation: Vancouver, Canada
• [Presentation] Augmentation of Leptin Receptor Signaling by Loss of Socs3 Induces Development of Gastric Tumors in Mice
  • Author(s): KYOKO INAGAKI-OHARA, SEIYA KATO, TAEKO DOHI, GORO MATSUZAKI, YASUHIKO MINOKOSHI, AKIHIKO YOSHIMURA
  • Organizer: America Diabetes Association
  • Place of Presentation: Chicago, US
• [Presentation] Reqirement of leptin receptor signaling for development of gastric cancer induced by SOCS3 loss in mice
  • Author(s): Kyoko Inagaki-Ohara, Akihiko Yoshimura, Goro Matsuzaki, Seiya Kato, Yasuhiko Minokoshi
  • Organizer: 日本生理学会
  • Place of Presentation: パシフィコ横浜（神奈川県）