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Actin filament assembly during myofibrillogenesis

Research Project

Project/Area Number 23590337
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General medical chemistry
Research InstitutionUniversity of Miyazaki (2013)
Kyushu University (2011-2012)

Principal Investigator

TAKEYA Ryu  宮崎大学, 医学部, 教授 (50335981)

Project Period (FY) 2011 – 2014
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsサルコメア / アクチン / 心筋 / 筋原線維 / 発生・分化 / 細胞・組織 / 循環器 / 循環器・高血圧
Outline of Final Research Achievements

Fhod3 is a cardiac member of the formin family proteins that play pivotal roles in actin filament assembly. In the present study, we show that Fhod3 KO mice appear normal up to embryonic day (E) 8.5, but fail to develop further and died by E11.5 with aborted development of myofibrils. These findings indicate that actin dynamics, regulated by Fhod3, participate in sarcomere organization during myofibrillogenesis and thus play a crucial role in heart development.

Report

(4 results)
  • 2014 Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (14 results)

All 2013 2012 2011

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (9 results) (of which Invited: 1 results)

  • [Journal Article] Dilated Cardiomyopathy-Associated <i>FHOD3</i> Variant Impairs the Ability to Induce Activation of Transcription Factor Serum Response Factor2013

    • Author(s)
      Arimura T, Takeya R, Ishikawa T, Yamano T, Matsuo A, Tatsumi T, Nomura T, Sumimoto H, Kimura A.
    • Journal Title

      Circulation Journal

      Volume: 77 Issue: 12 Pages: 2990-2996

    • DOI

      10.1253/circj.CJ-13-0255

    • NAID

      10031203585

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phosphorylation of Noxo1 at threonine 341 regulates its interaction with Noxa1 and the superoxide-producing activity of Nox1.2013

    • Author(s)
      Yamamoto A, Takeya R, Matsumoto M, Nakayama KI, Sumimoto H.
    • Journal Title

      FEBS J.

      Volume: 280 Issue: 20 Pages: 2145-5159

    • DOI

      10.1111/febs.12489

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression and subcellular localization of mammalian formin Fhod3 in the embryonic and adultheart2012

    • Author(s)
      Kan-o M, Takeya R, Taniguchi K, Tanoue Y, Tominaga R, and Sumimoto H
    • Journal Title

      PLoS One

      Volume: 7 Issue: 4 Pages: 34765-34765

    • DOI

      10.1371/journal.pone.0034765

    • Related Report
      2012 Research-status Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] High cell-autonomy of the anterior endomesoderm viewed in blastomere fate shift during regulative development in the isolated right halves of four-cell stage Xenopus embryos2012

    • Author(s)
      Masaaki Koga
    • Journal Title

      Development Growth and Differentiation

      Volume: 54 Issue: 7 Pages: 717-729

    • DOI

      10.1111/j.1440-169x.2012.01372.x

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Mammalian formin Fhod3 plays an essential role ln cardiogenesis by organizing myofibrillosenesis.2012

    • Author(s)
      Kan-O M., et al
    • Journal Title

      Biol. Open.

      Volume: 9 Issue: 9 Pages: 889-896

    • DOI

      10.1242/bio.20121370

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] formin相同蛋白質Fhod3のアクチン結合能は、マウス胎仔心筋のサルコメア構築に必須である2013

    • Author(s)
      神尾 明君, 藤本 智子, 武谷 立, 住本 英樹
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] formin相同蛋白質Fhod3変異による心筋症様変化2013

    • Author(s)
      武谷 立, 有村卓朗, 神尾 明君, 木村彰方, 住本 英樹
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Related Report
      2013 Annual Research Report
  • [Presentation] マウス胎仔心筋のサルコメア形成におけるformin相同蛋白質Fhod3のアクチン結合能の役割2013

    • Author(s)
      神尾 明君, 藤本 智子, 武谷 立, 住本 英樹
    • Organizer
      第65回日本細胞生物学会大会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] Role of Fhod3-mediated actin assembly in myofibrillogenesis during cardiac differentiation2013

    • Author(s)
      Ryu Takeya
    • Organizer
      International Workshop on Stem Cell Differentiation: The Influence of Biomaterials and Biomechanics
    • Place of Presentation
      中国・上海
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] The essential role of mammalian formin FHOD3 in sarcomere organization during heart development2012

    • Author(s)
      Ryu Takeya, Meikun Kan-o, Takaya Abe, Naoyuki Kitajima, Motohiro Nishida, Ryuji Tominaga, Hitoshi Kurose, and Hideki Sumimoto
    • Organizer
      第65回日本細胞生物学会大会
    • Place of Presentation
      神戸
    • Related Report
      2012 Research-status Report
  • [Presentation] Mammalian formin Fhod3 is required for sarcomere organization in the developing mouse heart2012

    • Author(s)
      武谷 立、神尾明君、阿部高也、北島直幸、西田基宏、富永隆治、黒瀬 等、住本英樹
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] formin蛋白質Fhod3は心臓形成における筋原線維の形成に必須のアクチン調節因子である2012

    • Author(s)
      武谷 立、神尾明君、阿部高也、北島直幸、西田基宏、富永隆治、黒瀬 等、住本英樹
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] formin相同蛋白質Fhod3のマウス胎仔、成獣、およびヒト心筋サルコメアにおける局在2011

    • Author(s)
      神尾明君、武谷 立、田ノ上禎久、富永隆治、住本英樹
    • Organizer
      第84回日本生化学大会
    • Place of Presentation
      京都
    • Related Report
      2011 Research-status Report
  • [Presentation] formin相同蛋白質Fhod3の心筋サルコメアにおける局在と機能2011

    • Author(s)
      神尾明君、武谷 立、田ノ上禎久、富永隆治、住本英樹
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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