| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
In complement system, lectin pathway activates complement by recognition of sugar chains on microbes. MASP has a pivotal role in the lectin pathway. Three MASPs (MASP-1, MASP-2 and MASP-3) were identified. We reported that MASP-1/3 activate complement D factor(fD), which is essential for the alternative pathway. In this study, we will investigate the mechanisms for activation of fD by MASP-1/3. During this study, MASP-1/3 defected patients were found. We found that MASP1/3 is essential for alternative pathway in human as well as mouse.
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