Analysis of novel chemokine receptor variant in cancer-associated inflammatory microenvironment
| Project/Area Number |
23590406
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Yokohama City University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Reiko 千葉大学, 真菌医学研究センター, 助教 (60143319)
AOKI Ichiro 横浜市立大学, 医学研究科, 教授 (00184028)
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| Co-Investigator(Renkei-kenkyūsha) |
MIYAGI Etsuko 横浜市立大学, 附属病院, 准教授 (40275053)
MIYAGI Yohei 神奈川県立がんセンター, がん分子病態研究部門, 部門長 (00254194)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 卵巣癌 / 炎症 / ケモカイン / 炎症性微小環境 / シグナル / 発癌 / 人体病理 |
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| Research Abstract |
We examined pathophysiology of impaired CXCR3 signaling in endometriosis-associated ovarian cancer (EAOC) under IFN-g enriched microenvironment.
The expression of CXCL4, a ligand of CXCR3-B, was gradually suppressed as cancer developed from endometriosis lesion. We confirmed that the responsible cell type expressing CXCL4 was macrophage. Interestingly, infiltrating macrophages in endometriosis were CD68 (+) CXCL4 (+) whereas those in EAOC were CD163 (+) CXCL4 (-). Furthermore, we found that suppressor of cytokine signaling (SOCS) was severely suppressed in these IFN-g-high EAOC.
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Report
(4 results)
Research Products
(75 results)
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[Journal Article] Intratumoral peripheral small papillary tuft (ITPSPT): A diagnostic clue of renal tumors associated with Birt-Hogg-Dubé syndrome.2014
Author(s)
Kuroda N, Furuya M, Nagashima Y, Gotoda H, Moritani S, Kawakami F, Imamura Y, Bando Y, Takahashi M, Kanayama H, Ota S, Michal M, Hes O, Nakatani Y.
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Journal Title
Ann Diagn Pathol
Volume: vol18
Pages: 171-176
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Multifocal and microscopic chromophobe renal cell carcinomatous lesions associated with"capsulomas"without FCLN gene abnormality2013
Author(s)
Sugimoto K, Takasawa A, Ichimiya S, Murata M, Kimura H, Aoyama T, Gille JJ, Kuroda N, Shimizu H, Hasegawa T, Sawada N, Furuya M, Nagashima Y.
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Journal Title
Pathol Int
Volume: 60
Pages: 510-5
DOI
Related Report
Peer Reviewed
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[Journal Article] Multifocal and microscopic chromophobe renal cell carcinomatous lesions associated with 'capsulomas' without FCLN gene abnormality2013
Author(s)
Sugimoto K, Takasawa A, Ichimiya S, Murata M, Kimura H, Aoyama T, Gille JJ, Kuroda N, Shimizu H, Hasegawa T, Sawada N, Furuya M, Nagashima Y
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Journal Title
Pathol Int.
Volume: 63
Pages: 510-515
Related Report
Peer Reviewed
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[Journal Article] Identification of miR-30d as a novel prognostic maker of prostate cancer2012
Author(s)
Kobayashi N, Uemura H, Nagahama K, Okudela K, Furuya M, Ino Y, Ito Y, Hirano H, Inayama Y, Aoki I, Nagashima Y, Kubota Y, Ishiguro H.
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Journal Title
Oncotarget
Volume: 3
Pages: 1455-1471
Related Report
Peer Reviewed
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[Presentation] 卵巣原発の腺扁平上皮癌の一例2013
Author(s)
筒井美帆, 松村舞依, 三宅暁夫, 宇高直子, 古屋充子, 山中正二, 大橋健一, 稲山嘉明
Organizer
第102回日本病理学会学術総会
Place of Presentation
ロイトン札幌 (北海道札幌市)
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