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Application of sphingosine-1-phosphate receptors to diagnosis and treatment for lymphohematopoietic neoplasms

Research Project

Project/Area Number 23590418
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Human pathology
Research InstitutionKawasaki Medical School

Principal Investigator

SADAHIRA YOSHITO  川崎医科大学, 医学部, 教授 (30178694)

Co-Investigator(Kenkyū-buntansha) AKIYAMA Takashi  川崎医科大学, 医学部, 准教授 (80294411)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsスフィンゴシン-1-リン酸 / 受容体 / 悪性リンパ腫 / 低酸素 / FTY720 / リンパ腫 / STAT3 / HTLV-1 / 異種移植片 / 低酸素環境 / スフィンゴシン-1-リン酸受容体 / 白血病
Research Abstract

In this study, we found that sphingosine-1-phosphate receptor 1 (S1PR1) was expressed in 12% of 183 diffuse large B-cell lymphoma (DLBCL) cases, in particular, as high as 56% in primary testicular DLBCL. However, the S1PR1 expression status was not associated with STAT3 activation. S1PR1 was also expressed in 20% of 25 adult T-cell leukemia/lymphoma (ATLL) cases. S1PR1 expression of HTLV-1-infected T cell lines was elevated under hypoxic condition. FTY720, functional antagonist of S1PR1, inhibited activation of STAT3,suppressed cell proliferation, and induced apoptosis of HTLV-1-infected T cell lines in vitro. FTY720 (10mg/kg) treatment did not induce significant suppression of S1PR1 expression nor tumor growth in SCID xenograft model of HTLV-1-infected T cell line HUT102. induce significant suppression of S1PR1 expression nor tumor growth in SCID xenograft model of HTLV-1-infected T cell line HUT102.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (19 results)

All 2014 2013 2012 2011 Other

All Presentation (15 results) Remarks (4 results)

  • [Presentation] 白血化・骨髄浸潤を示し, S1PR1の発現が低下していたマントル細胞リンパ腫の3例2014

    • Author(s)
      藤原英世, 西村広健, 秋山隆, 伊禮功, 濱崎周次, 定平吉都, 海野正俊, 竹内誠, 物部泰昌
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      京王プラザホテル(東京)
    • Year and Date
      2014-04-27
    • Related Report
      2013 Final Research Report
  • [Presentation] Primary testicular diffuse large B-cell lymphomaにおけるsphingosine-1-phosphate receptor 1の高発現2014

    • Author(s)
      是澤里紗, 岡大五, 藤原英世, 定平吉都
    • Organizer
      第103回日本病理学会総会
    • Place of Presentation
      広島国際会議場(広島)
    • Year and Date
      2014-04-25
    • Related Report
      2013 Final Research Report
  • [Presentation] FTY720によるHTLV-1感染T細胞株におけるSTAT3活性化とFOXP3発現の抑制2013

    • Author(s)
      定平吉都, 西村広健, 藤原英世, 小原由美, 秋山隆, 伊禮功, 濱崎周次, 物部泰昌
    • Organizer
      第102回日本病理学会総会
    • Place of Presentation
      札幌芸文館(札幌)
    • Year and Date
      2013-06-08
    • Related Report
      2013 Final Research Report
  • [Presentation] HTLV-1感染T細胞株の低酸素によるFOXP3発現の増強とFTY720の効果2013

    • Author(s)
      岡大五, 是澤里紗, 杉原尚, 定平吉都
    • Organizer
      第53回日本リンパ網内系学会総会
    • Place of Presentation
      京都国際会議場(京都)
    • Year and Date
      2013-05-18
    • Related Report
      2013 Final Research Report
  • [Presentation] リンパ造血器腫瘍の診断・予後予測へのsphingosine-1-phosphate receptorの応用2012

    • Author(s)
      定平吉都
    • Organizer
      第3回川崎医学会
    • Place of Presentation
      川崎医科大学校舎棟M-800(倉敷)
    • Year and Date
      2012-08-04
    • Related Report
      2013 Final Research Report
  • [Presentation] 高濃度のFTY720はHTLV-1感染T細胞株におけるSTAT3の恒常的活性化をS1PR1非依存性に抑制する2012

    • Author(s)
      定平吉都, 西村広健, 藤原英世, 秋山隆, 伊禮功, 濱崎周次, 物部泰昌, 塩見達志
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      京王プラザホテル(東京)
    • Year and Date
      2012-04-28
    • Related Report
      2013 Final Research Report
  • [Presentation] Impact of FTY720 on S1PR1-positive HTLV-1-infected T-cell lines2012

    • Author(s)
      Sadahira Y, Fujiwara H, Nishimura H, Akiyama T, Irei I, Hamazaki S
    • Organizer
      USCAP 101^st annual meeting
    • Place of Presentation
      Vancouver convetion center (Vancouver, Canada)
    • Related Report
      2013 Final Research Report
  • [Presentation] Impact of FTY720 on S1PR1-Positive HTLV-1-Infected T-Cell Lines2012

    • Author(s)
      Sadahira Y, Fujiwara H, Nishimura H, Akiyama T, Irei I, Hamazaki S
    • Organizer
      USCAP 101st annual meeting
    • Place of Presentation
      Vancouver convention center (Canada)
    • Related Report
      2011 Research-status Report
  • [Presentation] The impact of FTY720 on malignant lymphoma2011

    • Author(s)
      Nishimura H, Fujiwara H, Akiyama T, Irei I, Monobe Y, Hamazaki S, Sugihara T, Sakai A, Sadahira Y
    • Organizer
      第73回日本血液学会学術集会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2011-10-16
    • Related Report
      2013 Final Research Report
  • [Presentation] The impact of FTY720 on malignant lymphoma2011

    • Author(s)
      Nishimura H, Fujiwara H, Akiyama T, Irei I, Monobe Y, Hamazaki S, Sugihara T, Sakai A, Sadahira Y.
    • Organizer
      第73回日本血液学会学術集会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Related Report
      2011 Research-status Report
  • [Presentation] ヒト中枢神経系疾患におけるスフィンゴシン-1-リン酸受容体の発現とその役割の検討2011

    • Author(s)
      西村広健, 藤原英世, 伊禮功, 物部泰昌, 秋山隆, 濱崎周次, 定平吉都
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2011 Research-status Report
  • [Presentation] Primary testicular diffuse large B-cell lymphomaにおけるsphingosine-1-phosphate receptor 1の高発現

    • Author(s)
      是澤 里紗、岡 大五、藤原 英世、定平 吉都
    • Organizer
      日本病理学会
    • Place of Presentation
      広島国際会議場
    • Related Report
      2013 Annual Research Report
  • [Presentation] リンパ造血器腫瘍の診断・予後予測へのsphingosine-1-phosphate receptorの応用

    • Author(s)
      定平 吉都
    • Organizer
      第3回川崎医学会
    • Place of Presentation
      川崎医科大学校舎棟M-800(倉敷市)
    • Related Report
      2012 Research-status Report
  • [Presentation] HTLV-1感染T細胞株の低酸素によるFOXP3発現の増強とFTY720の効果

    • Author(s)
      岡大五,是澤里紗,杉原尚,定平吉都
    • Organizer
      第53回日本リンパ網内系学会総会
    • Place of Presentation
      京都国際会議場(京都)
    • Related Report
      2012 Research-status Report
  • [Presentation] FTY720によるHTLV-1感染T細胞株におけるSTAT3活性化とFOXP3発現の抑制

    • Author(s)
      定平吉都,西村広健,藤原英世,小原由美、秋山隆,伊禮功,濱崎周次,物部泰昌
    • Organizer
      第102回日本病理学会総会
    • Place of Presentation
      札幌芸文館(札幌)
    • Related Report
      2012 Research-status Report
  • [Remarks]

    • URL

      http://www.kawasaki-m.ac.jp/pathology/studeis.html

    • Related Report
      2013 Final Research Report
  • [Remarks] 科学研究費補助金による研究について

    • URL

      http://www.kawasaki-m.ac.jp/pathology/studeis.html

    • Related Report
      2013 Annual Research Report
  • [Remarks] 科学研究費補助金による研究について

    • URL

      http://www.kawasaki-m.ac.jp/pathology/

    • Related Report
      2012 Research-status Report
  • [Remarks]

    • URL

      http://www.kawasaki-m.ac.jp/pathology/

    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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