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Search for new biomarkers about Langerhans cell histiocytosis using mass spectrometry

Research Project

Project/Area Number 23590426
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Human pathology
Research InstitutionTottori University

Principal Investigator

MURAKAMI Ichiro  鳥取大学, 医学部, 准教授 (80548701)

Co-Investigator(Renkei-kenkyūsha) OKA Takashi  岡山大学, 医葉薬学総合研究科, 助教 (50160651)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsランゲルハンス細胞組織球症 / バイオマーカー / 質量分析 / 国際情報交換(フランス) / ランゲルハンス細胞組織球症(LCH) / LC-MS / MALDI-TOF/TOF-MS / IL17R / IL17 / MCPyV / microdissection
Research Abstract

We proposed possibility that LCH has both neoplastic character and reactive character. As a trigger of the reactive origin we proposed the dermotropic Merkel cell polyomavirus (MCPyV) as a pathogenic agent. The lesional hyperreactivity may define the clinical courses of LCH. Though primary infection with MCPyV may play a significant pathogenic role in LCH, other mechanisms might also play important roles in LCH.
As clues to understand these mechanisms, we think serum biomarkers are important. LCH consists of two subtypes: single-system LCH (SS-LCH) with favorable prognosis and multisystem LCH (MS-LCH) with poor prognosis. LCH is also classified as either LCH developed in at least one high-risk organ (RO (+)) or LCH developed in organ without high-risk organ (LCH-RO (-)). As a preliminary analysis we already delineated 2 candidate biomarkers in sera which differentiate the LCH from controls, MS-LCH from SS-LCH, or LCH-RO (+) from LCH-RO (-), respectively.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (18 results)

All 2014 2013 2012 2011 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (11 results) Remarks (3 results)

  • [Journal Article] High viral load of Merkel cell polyomavirus DNA sequences in Langerhans cell sarcoma tissues2014

    • Author(s)
      Murakami I, Matsushita M, Iwasaki T, Kuwamoto S, Kato M, Horie Y, Hayashi K, Gogusev J, Jaubert F, Nakamoto S, Yamakawa M, Nakamine H, Takata K, Oka T, Yoshino T
    • Journal Title

      Infect Agent Cancer

      Volume: 9 Pages: 15-15

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Merkel cell polyomavirus DNA sequences in peripheral blood and tissues from patients with Langerhans cell histiocytosis.2014

    • Author(s)
      Murakami I, Matsushita M, Iwasaki T, Kuwamoto S, Kato M, Horie Y, Hayashi K, Imamura T, Morimoto A, Imashuku S, Gogusev J, Jaubert F, Takata K, Oka T, Yoshino T.
    • Journal Title

      Hum Pathol.

      Volume: 45 Issue: 1 Pages: 119-126

    • DOI

      10.1016/j.humpath.2013.05.028

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] IL-17A receptor expression differs between subclasses of Langerhans cell histiocytosis, which might settle the IL-17A controversy.2013

    • Author(s)
      Murakami I, Morimoto A, Oka T, Kuwamoto S, Kato M, Horie Y, Hayashi K, Gogusev J, Jaubert F, Imashuku S, Al-Kadar LA, Takata K, Yoshino T.
    • Journal Title

      Virchows Arch

      Volume: 462 Issue: 2 Pages: 219-228

    • DOI

      10.1007/s00428-012-1360-6

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Tyrosine phosphatase SHP-1 is expressed higher in multisystem than in single-system Langerhans cell histiocytosis by immunohistochemistry2011

    • Author(s)
      Murakami I, Oka T, Kuwamoto S, Kato M, Hayashi K, Gogusev J, Imamura T, Morimoto A, Imashuku S, Yoshino T
    • Journal Title

      Virchows Arch

      Volume: 459 Issue: 2 Pages: 227-234

    • DOI

      10.1007/s00428-011-1090-1

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Presentation] メルケル細胞ポリオーマウイルス解析に依るランゲルハンス細胞肉腫の疾患モデル2014

    • Author(s)
      村上一郎, 松下倫子, 岩崎健, 桑本聡史, 加藤雅子, 堀江靖, 林一彦, 前田智治, 中本周, 山川光徳, 中峯寛和, 高田尚良, 岡剛史, 吉野正
    • Organizer
      第103回日本病理学会総会
    • Place of Presentation
      広島
    • Related Report
      2013 Final Research Report
  • [Presentation] 網羅的遺伝子発現解析, メルケル細胞ポリオーマウイルス解析に依るランゲルハンス細胞組織球症の疾患モデル2013

    • Author(s)
      村上一郎, 松下倫子, 岩崎健, 桑本聡史, 加藤雅子, 堀江靖, 林一彦, 岡剛史, 吉野正
    • Organizer
      第102回日本病理学会総会
    • Place of Presentation
      札幌
    • Related Report
      2013 Final Research Report
  • [Presentation] 網羅的遺伝子発現解析、メルケル細胞ポリオーマウイルス解析に依るランゲルハンス細胞組織球症の疾患モデル2013

    • Author(s)
      村上一郎、他
    • Organizer
      第102回日本病理学会総会
    • Place of Presentation
      札幌(ロイトン札幌)
    • Related Report
      2012 Research-status Report
  • [Presentation] ランゲルハンス細胞組織球症(LCH)におけるIL-17RAの検討2012

    • Author(s)
      村上一郎, 岡剛史, 桑本聡史, 加藤雅子, 林一彦, 吉野正
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] ランゲルハンス細胞組織球症(LCH)におけるメルケル細胞ポリオーマウイルス(MCPyV)感染の検討2012

    • Author(s)
      松下倫子, 村上一郎, 岩崎健, 桑本聡史, 加藤雅子, 北村幸郷
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] ランゲルハンス細胞組織球症(LCH)におけるIL-17RA の検討2012

    • Author(s)
      村上一郎、岡 剛史、桑本聡史、加藤雅子、林 一彦、
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      京王プラザホテル(東京)
    • Related Report
      2011 Research-status Report
  • [Presentation] ランゲルハンス細胞組織球症(LCH)におけるメルケル細胞ポリオーマウイルス(MCPyV)感染の検討2012

    • Author(s)
      松下倫子、村上一郎、岩崎 健、桑本聡史、加藤雅子、北村幸郷、林 一彦
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      京王プラザホテル(東京)
    • Related Report
      2011 Research-status Report
  • [Presentation] メルケル細胞癌:他の皮膚腫瘍との合併腫瘍に対する組織学的検討および文献的考察2011

    • Author(s)
      桑本聡史, 檜垣裕美, 加藤雅子, 村上一郎, 堀江靖, 林一彦
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] Merkel cell polyomavirusの剖検症例における感染の検討2011

    • Author(s)
      松下倫子, 岩崎健, 桑本聡史, 檜垣裕美, 加藤雅子, 村上一郎, 北村幸郷, 林一彦
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] HE染色によるMerkel cell carcinomaの形態的特徴からMerkel cell polyomavirusの感染の予測はどの程度可能か?2011

    • Author(s)
      岩崎健, 松下倫子, 桑本聡史, 檜垣裕美, 加藤雅子, 村上一郎, 堀江靖, 林一彦
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] PTPN6 (SHP-1)遺伝子導入Langerhans cell様細胞株(ELD-1)に関する検討2011

    • Author(s)
      村上一郎, 岡剛史, 桑本聡史, 加藤雅子, 堀江靖, 林一彦, 佐藤妃映, 高橋聖之, 吉野正
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Remarks] 鳥取大学医学部医学科分子病理学分野

    • URL

      http://www.med.tottori-u.ac.jp/molepath/

    • Related Report
      2013 Final Research Report
  • [Remarks] LCHに関する科学研究費

    • URL

      http://www.med.tottori-u.ac.jp/molepath/160/388.html

    • Related Report
      2012 Research-status Report
  • [Remarks] 業績(Ichiro Murakami)

    • URL

      http://www.med.tottori-u.ac.jp/molepath/167/4452.html

    • Related Report
      2012 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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