Search for new biomarkers about Langerhans cell histiocytosis using mass spectrometry
| Project/Area Number |
23590426
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Tottori University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
OKA Takashi 岡山大学, 医葉薬学総合研究科, 助教 (50160651)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | ランゲルハンス細胞組織球症 / バイオマーカー / 質量分析 / 国際情報交換（フランス） / ランゲルハンス細胞組織球症（LCH） / LC-MS / MALDI-TOF/TOF-MS / IL17R / IL17 / MCPyV / microdissection |
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| Research Abstract |
We proposed possibility that LCH has both neoplastic character and reactive character. As a trigger of the reactive origin we proposed the dermotropic Merkel cell polyomavirus (MCPyV) as a pathogenic agent. The lesional hyperreactivity may define the clinical courses of LCH. Though primary infection with MCPyV may play a significant pathogenic role in LCH, other mechanisms might also play important roles in LCH.
As clues to understand these mechanisms, we think serum biomarkers are important. LCH consists of two subtypes: single-system LCH (SS-LCH) with favorable prognosis and multisystem LCH (MS-LCH) with poor prognosis. LCH is also classified as either LCH developed in at least one high-risk organ (RO (+)) or LCH developed in organ without high-risk organ (LCH-RO (-)). As a preliminary analysis we already delineated 2 candidate biomarkers in sera which differentiate the LCH from controls, MS-LCH from SS-LCH, or LCH-RO (+) from LCH-RO (-), respectively.
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] High viral load of Merkel cell polyomavirus DNA sequences in Langerhans cell sarcoma tissues2014
Author(s)
Murakami I, Matsushita M, Iwasaki T, Kuwamoto S, Kato M, Horie Y, Hayashi K, Gogusev J, Jaubert F, Nakamoto S, Yamakawa M, Nakamine H, Takata K, Oka T, Yoshino T
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Journal Title
Infect Agent Cancer
Volume: 9
Pages: 15-15
Related Report
Peer Reviewed
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[Journal Article] Merkel cell polyomavirus DNA sequences in peripheral blood and tissues from patients with Langerhans cell histiocytosis2014
Author(s)
Murakami I, Matsushita M, Iwasaki T, Kuwamoto S, Kato M, Horie Y, Hayashi K, Imamura T, Morimoto A, Imashuku S, Gogusev J, Jaubert F, Takata K, Oka T, Yoshino T.
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Journal Title
Hum Pathol
Volume: 45
Pages: 119-126
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] IL-17A receptor expression differs between subclasses of Langerhans cell histiocytosis, which might settle the IL-17A controversy2013
Author(s)
Murakami I, Morimoto A, Oka T, Kuwamoto S, Kato M, Horie Y, Hayashi K, Gogusev J, Jaubert F, Imashuku S, Al-Kadar LA, Takata K, Yoshino T
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Journal Title
Virchows Arch
Volume: 462(2)
Pages: 219-28
Related Report
Peer Reviewed
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[Journal Article] IL-17A receptor expression differs between subclasses of Langerhans cell histiocytosis, which might settle the IL-17A controversy.2013
Author(s)
Murakami I, Morimoto A, Oka T, Kuwamoto S, Kato M, Horie Y, Hayashi K, Gogusev J, Jaubert F, Imashuku S, Al-Kadar LA, Takata K, Yoshino T.
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Journal Title
Virchows Arch.
Volume: 462
Pages: 219-228
Related Report
Peer Reviewed
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[Presentation] メルケル細胞ポリオーマウイルス解析に依るランゲルハンス細胞肉腫の疾患モデル2014
Author(s)
村上一郎, 松下倫子, 岩崎健, 桑本聡史, 加藤雅子, 堀江靖, 林一彦, 前田智治, 中本周, 山川光徳, 中峯寛和, 高田尚良, 岡剛史, 吉野正
Organizer
第103回日本病理学会総会
Place of Presentation
広島
Related Report
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