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Comprehensive molecular and pathological analysis of Mesothelin expression

Research Project

Project/Area Number 23590435
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Human pathology
Research InstitutionJuntendo University

Principal Investigator

WAKIYA Midori  順天堂大学, 医学部, 助教 (00220848)

Co-Investigator(Kenkyū-buntansha) KAJINO Kazunori  順天堂大学, 医学部, 助教 (80260066)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords中皮腫 / ERC/Mesothelin / ERC/mesothelin / miRNA / 性差 / estradiol / Mesothelin / 悪性腫瘍 / 発癌 / 分子病理
Research Abstract

Mesothelioma, caused by the exposure to asbestos, is a malignant tumor with poor prognosis. ERC/Mesothelin (ERC) is a tumor maker useful for the diagnosis of mesothelioma and the evaluation of its prognosis. In this study, we showed that the expression of ERC is regulated by microRNA. To establish the novel treatment for mesothelioma, we immunized mice with cultured cells derived from human mesothelioma, and isolated the monoclonal antibodies having the anti-proliferative activity for the mesothelioma cells.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (19 results)

All 2014 2013 2012 2011

All Journal Article (7 results) (of which Peer Reviewed: 5 results) Presentation (12 results)

  • [Journal Article] ERC/ mesothelin is expressed in human gastric cancer tissues and cell lines2014

    • Author(s)
      Ito T, Kajino K, Abe M,et al
    • Journal Title

      Oncol Reports

      Volume: 31 Pages: 27-33

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Todo S. C-ERC/ mesothelin provokes lymphatic invasion of colorectal adenocarcinoma2014

    • Author(s)
      Kawamata F, Homma S, Kamachi H, Einama T, Kato Y, Tsuda M, Tanaka S, Maeda M, Kajino K, Hino O, Takahashi N, Kamiyama T, Nishihara H, Taketomi A
    • Journal Title

      J Gastroenterol

      Volume: 49 Pages: 81-92

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] ERC/mesothelin is expressed in human gastric cancer tissues and cell lines2014

    • Author(s)
      Ito T, Kajino K, Abe M, Sato K, Maekawa H, Sakurada M, Orita H, Wada R, Kajiyama Y, Hino O.
    • Journal Title

      Oncol Reports

      Volume: 31 Pages: 27-33

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] C-ERC/mesothelin provokes lymphatic invasion of colorectal adenocarcinoma2014

    • Author(s)
      Kawamata F, Homma S, Kamachi H, Einama T, Kato Y, Tsuda M, Tanaka S, Maeda M, Kajino K, Hino O, Takahashi N, Kamiyama T, Nishihara H, Taketomi A, Todo S
    • Journal Title

      J Gastroenterology

      Volume: 49 Issue: 1 Pages: 81-92

    • DOI

      10.1007/s00535-013-0773-6

    • NAID

      120005537455

    • Related Report
      2013 Annual Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article]2012

    • Author(s)
      梶野一徳, 樋野興夫
    • Journal Title

      RNA干渉と肝疾患の治療生体の科学

      Volume: 63巻第2号 Pages: 129-132

    • Related Report
      2013 Final Research Report
  • [Journal Article] RNA干渉と肝疾患の治療2012

    • Author(s)
      梶野一徳、樋野興夫
    • Journal Title

      生体の科学

      Volume: 63巻第2号 Pages: 129-132

    • Related Report
      2012 Research-status Report
  • [Journal Article] DNA binding protein A expression and methylation status in hepatocellular carcinoma and the adjacent tissue2012

    • Author(s)
      Yaesn M et al.
    • Journal Title

      International Journal of Oncology

      Volume: 40 Pages: 789-797

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 悪性中皮腫に対する新規標的抗体作製およびその発現の検討2013

    • Author(s)
      水谷奈津子, 松岡周二, 梶野一徳, 脇屋緑, 樋野興夫
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2013-10-05
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] miRNAによるERC/mesothelin転写産物の制御2013

    • Author(s)
      譚珂, 梶野一徳, 脇屋緑, 樋野興夫
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2013-10-03
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 悪性中皮腫に対する新規治療抗体の作製およびその標的分子発現の検討2013

    • Author(s)
      水谷奈津子, 松岡周二, 阿部雅明, 梶野一徳, 脇屋緑, 樋野興夫
    • Organizer
      第102回日本病理学会総会
    • Place of Presentation
      ロイトン札幌
    • Year and Date
      2013-06-07
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 中皮腫におけるERC/mesothelin発現制御機構2012

    • Author(s)
      譚珂, 梶野一徳, 脇屋緑, 樋野興夫
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ロイトン札幌
    • Year and Date
      2012-09-19
    • Related Report
      2013 Final Research Report
  • [Presentation] 中皮腫におけるERC/mesothelin発現制御機構2012

    • Author(s)
      譚珂、梶野一徳、脇屋緑、樋野興夫
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report
  • [Presentation] 中皮腫におけるERC/Mesothelinの発現制御機構の解明2011

    • Author(s)
      譚珂, 梶野一徳, 百瀬修二, 他
    • Organizer
      第70回日本癌学会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2011-10-03
    • Related Report
      2013 Final Research Report
  • [Presentation] N-ERC/Mesothelinの結合蛋白質の単離2011

    • Author(s)
      王特格喜白音, 梶野一徳, 樋野興夫, 他
    • Organizer
      第70回日本癌学会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2011-10-03
    • Related Report
      2013 Final Research Report
  • [Presentation] 肺骨化症の剖検例2011

    • Author(s)
      脇屋緑, 原田紀宏, 春日文子, 他
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2011-04-28
    • Related Report
      2013 Final Research Report
  • [Presentation] 肺骨化症の剖検例2011

    • Author(s)
      脇屋 緑、原田 紀宏、春日 文子、他
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      パシフィコ横浜 (横浜)
    • Related Report
      2011 Research-status Report
  • [Presentation] 中皮腫における ERC/Mesothelin の発現制御機構の解明2011

    • Author(s)
      譚 珂、梶野 一徳、百瀬 修二、他
    • Organizer
      第70回日本癌学会
    • Place of Presentation
      名古屋国際会議場 (名古屋)
    • Related Report
      2011 Research-status Report
  • [Presentation] N-ERC/Mesothelin の結合蛋白質の単離2011

    • Author(s)
      王 特格喜白音、梶野 一徳、樋野 興夫、他
    • Organizer
      第70回日本癌学会
    • Place of Presentation
      名古屋国際会議場 (名古屋)
    • Related Report
      2011 Research-status Report
  • [Presentation] 乳癌における dbpA 遺伝子の発現異常2011

    • Author(s)
      Obulhasim G、梶野 一徳、馬合木特 亜森、他
    • Organizer
      第70回日本癌学会
    • Place of Presentation
      名古屋国際会議場 (名古屋)
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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