Comprehensive molecular and pathological analysis of Mesothelin expression

• Project/Area Number: 23590435
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: Juntendo University
• Principal Investigator: WAKIYA Midori 順天堂大学, 医学部, 助教 (00220848)
• Co-Investigator(Kenkyū-buntansha): KAJINO Kazunori 順天堂大学, 医学部, 助教 (80260066)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 中皮腫 / ERC/Mesothelin / ERC/mesothelin / miRNA / 性差 / estradiol / Mesothelin / 悪性腫瘍 / 発癌 / 分子病理

Research Abstract

Mesothelioma, caused by the exposure to asbestos, is a malignant tumor with poor prognosis. ERC/Mesothelin (ERC) is a tumor maker useful for the diagnosis of mesothelioma and the evaluation of its prognosis. In this study, we showed that the expression of ERC is regulated by microRNA. To establish the novel treatment for mesothelioma, we immunized mice with cultured cells derived from human mesothelioma, and isolated the monoclonal antibodies having the anti-proliferative activity for the mesothelioma cells.

Research Products

• [Journal Article] ERC/ mesothelin is expressed in human gastric cancer tissues and cell lines (2014)
  • Author(s): Ito T, Kajino K, Abe M,et al
  • Journal Title: Oncol Reports Volume: 31 Pages: 27-33
  • Peer Reviewed
• [Journal Article] Todo S. C-ERC/ mesothelin provokes lymphatic invasion of colorectal adenocarcinoma (2014)
  • Author(s): Kawamata F, Homma S, Kamachi H, Einama T, Kato Y, Tsuda M, Tanaka S, Maeda M, Kajino K, Hino O, Takahashi N, Kamiyama T, Nishihara H, Taketomi A
  • Journal Title: J Gastroenterol Volume: 49 Pages: 81-92
  • Peer Reviewed
• [Journal Article] ERC/mesothelin is expressed in human gastric cancer tissues and cell lines (2014)
  • Author(s): Ito T, Kajino K, Abe M, Sato K, Maekawa H, Sakurada M, Orita H, Wada R, Kajiyama Y, Hino O.
  • Journal Title: Oncol Reports Volume: 31 Pages: 27-33
  • Peer Reviewed
• [Journal Article] C-ERC/mesothelin provokes lymphatic invasion of colorectal adenocarcinoma (2014)
  • Author(s): Kawamata F, Homma S, Kamachi H, Einama T, Kato Y, Tsuda M, Tanaka S, Maeda M, Kajino K, Hino O, Takahashi N, Kamiyama T, Nishihara H, Taketomi A, Todo S
  • Journal Title: J Gastroenterology Volume: 49 Issue: 1 Pages: 81-92
  • DOI: 10.1007/s00535-013-0773-6
  • NAID: 120005537455
  • Peer Reviewed
• [Journal Article] (2012)
  • Author(s): 梶野一徳, 樋野興夫
  • Journal Title: RNA干渉と肝疾患の治療生体の科学 Volume: 63巻第2号 Pages: 129-132
• [Journal Article] RNA干渉と肝疾患の治療 (2012)
  • Author(s): 梶野一徳、樋野興夫
  • Journal Title: 生体の科学 Volume: 63巻第2号 Pages: 129-132
• [Journal Article] DNA binding protein A expression and methylation status in hepatocellular carcinoma and the adjacent tissue (2012)
  • Author(s): Yaesn M et al.
  • Journal Title: International Journal of Oncology Volume: 40 Pages: 789-797
  • Peer Reviewed
• [Presentation] 悪性中皮腫に対する新規標的抗体作製およびその発現の検討 (2013)
  • Author(s): 水谷奈津子, 松岡周二, 梶野一徳, 脇屋緑, 樋野興夫
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2013-10-05
• [Presentation] miRNAによるERC/mesothelin転写産物の制御 (2013)
  • Author(s): 譚珂, 梶野一徳, 脇屋緑, 樋野興夫
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2013-10-03
• [Presentation] 悪性中皮腫に対する新規治療抗体の作製およびその標的分子発現の検討 (2013)
  • Author(s): 水谷奈津子, 松岡周二, 阿部雅明, 梶野一徳, 脇屋緑, 樋野興夫
  • Organizer: 第102回日本病理学会総会
  • Place of Presentation: ロイトン札幌
  • Year and Date: 2013-06-07
• [Presentation] 中皮腫におけるERC/mesothelin発現制御機構 (2012)
  • Author(s): 譚珂, 梶野一徳, 脇屋緑, 樋野興夫
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: ロイトン札幌
  • Year and Date: 2012-09-19
• [Presentation] 中皮腫におけるERC/mesothelin発現制御機構 (2012)
  • Author(s): 譚珂、梶野一徳、脇屋緑、樋野興夫
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌
• [Presentation] 中皮腫におけるERC/Mesothelinの発現制御機構の解明 (2011)
  • Author(s): 譚珂, 梶野一徳, 百瀬修二, 他
  • Organizer: 第70回日本癌学会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2011-10-03
• [Presentation] N-ERC/Mesothelinの結合蛋白質の単離 (2011)
  • Author(s): 王特格喜白音, 梶野一徳, 樋野興夫, 他
  • Organizer: 第70回日本癌学会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2011-10-03
• [Presentation] 肺骨化症の剖検例 (2011)
  • Author(s): 脇屋緑, 原田紀宏, 春日文子, 他
  • Organizer: 第100回日本病理学会総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2011-04-28
• [Presentation] 肺骨化症の剖検例 (2011)
  • Author(s): 脇屋 緑、原田 紀宏、春日 文子、他
  • Organizer: 第１００回日本病理学会総会
  • Place of Presentation: パシフィコ横浜 (横浜)
• [Presentation] 中皮腫における ERC/Mesothelin の発現制御機構の解明 (2011)
  • Author(s): 譚 珂、梶野 一徳、百瀬 修二、他
  • Organizer: 第７０回日本癌学会
  • Place of Presentation: 名古屋国際会議場 (名古屋)
• [Presentation] N-ERC/Mesothelin の結合蛋白質の単離 (2011)
  • Author(s): 王 特格喜白音、梶野 一徳、樋野 興夫、他
  • Organizer: 第７０回日本癌学会
  • Place of Presentation: 名古屋国際会議場 (名古屋)
• [Presentation] 乳癌における dbpA 遺伝子の発現異常 (2011)
  • Author(s): Obulhasim G、梶野 一徳、馬合木特 亜森、他
  • Organizer: 第７０回日本癌学会
  • Place of Presentation: 名古屋国際会議場 (名古屋)