The NK cell receptor KIR2DL4 on human mast cells

• Project/Area Number: 23590437
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: Kyoto University
• Principal Investigator: KATAOKA Tatsuki 京都大学, 医学(系)研究科(研究院), 助教 (20343254)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: マスト細胞 / アレルギー / NK活性 / KIR2DL4 / SCF

Research Abstract

The killer cell Ig-like receptor (KIR) 2DL4 (CD158d) acts as a receptor for human leukocyte antigen (HLA)-G and is expressed on almost all human NK cells. The expression and function of KIR2DL4 in other hematopoietic cells is poorly understood. Here, we focused on human mast cells, which exhibit similar cytotoxic activity to NK cells. KIR2DL4 was detected in all examined human cultured mast cells derived from healthy volunteers (huMC), the human mast cell line LAD2, and human non-neoplastic mast cells including pathological specimens of skin. An agonistic antibody against KIR2DL4 decreased KIT-mediated and IgE-triggered responses of LAD2 cells by activating Src homology 2-containing protein tyrosine phosphatase (SHP)-2. These findings would show that KIR2DL4 is a new target for the treatment of mast cell-related allergic diseases.

Research Products

• [Journal Article] DIHS/DRESS with Remarkable Eosinophilic Pneumonia Caused by Zonisamide (2014)
  • Author(s): Shibuya R, Tanizaki H, Nakajima S, Koyanagi I, Kataoka TR, Miyachi Y, Kabashima K
  • Journal Title: Acta Derm Venereol Volume: 95 Issue: 2 Pages: 229-230
  • DOI: 10.2340/00015555-1863
  • NAID: 120006223399
  • Peer Reviewed
• [Journal Article] Apparent diffusion coefficient as a potential surrogate marker for Ki-67 index in mucinous breast carcinoma. (2014)
  • Author(s): Onishi N, Kanao S, Kataoka M, Iima M, Sakaguchi R, Kawai M, Kataoka T, Mikami Y, Toi M, Togashi K., et al.
  • Journal Title: Journal of Magnetic Resonance Imaging. Volume: (印刷中) Issue: 3 Pages: 24615-24615
  • DOI: 10.1002/jmri.24615
  • Peer Reviewed
• [Journal Article] Coexistent Skin Lesions of Vitiligo and Psoriasis Vulgaris. Immunohistochemical Analyses for IL-17A-producing Cells and Regulatory T cells. (2014)
  • Author(s): Ono S, Tanizaki H, Otsuka A, Endo Y, Koyanagi I, Kataoka TR, Miyachi Y, Kabashima K.
  • Journal Title: Acta Dermato-Venereologica Volume: 94 Issue: 3 Pages: 329-330
  • DOI: 10.2340/00015555-1713
  • Peer Reviewed
• [Journal Article] Serum granusin as a positive key marker of activity of alopecia areata. (2014)
  • Author(s): Ono S, Otsuka A, Kataoka TR, Koyanagi I, Miyachi Y, Kabashima K.
  • Journal Title: Journal of Dermatological Science Volume: 73 Issue: 1 Pages: 74-79
  • DOI: 10.1016/j.jdermsci.2013.08.009
  • Peer Reviewed
• [Journal Article] Serum granulysin as a possible key marker of the activity of alopecia areata. (2014)
  • Author(s): Ono S, Otsuka A, Yamamoto Y, Kataoka TR, Koyanagi I, Miyachi Y, Kabashima K.
  • Journal Title: J Dermatol Sci. Volume: 73 Pages: 74-79
  • Peer Reviewed
• [Journal Article] CD72 regulates the growth of KIT-mutated leukemia cell line Kasumi-1 open (2013)
  • Author(s): Kataoka TR, Kumanogoh A, Hirata M, Moriyoshi K, UeshimaC, Kawahara M, Tsuruyama T, Haga H.
  • Journal Title: Sci Rep Volume: 3 Issue: 1 Pages: 2861-2861
  • DOI: 10.1038/srep02861
  • Peer Reviewed
• [Journal Article] PD-1 regulates the growth of human mastocytosis cells (2013)
  • Author(s): Kataoka TR, Fujimoto M, Moriyoshi K, Koyanagi I, Ueshima C, Kono F, Tsuruyama T, Okayama Y, Ra C, Haga H
  • Journal Title: Allergol Int. Volume: 62(1) Pages: 99-104
• [Journal Article] Fc receptor beta chain deficiency exacerbates murine arthritis in the anti-type II collagen antibody-induced experimental model. (2013)
  • Author(s): Ohtsubo-Yoshioka M, Nunomura S, Kataoka TR, Okayama Y, Ra C.
  • Journal Title: Mod Rheumatol. Volume: (In press) Issue: 4 Pages: 804-810
  • DOI: 10.1007/s10165-012-0749-z
  • NAID: 10031189177
  • Peer Reviewed
• [Journal Article] PD-1 Regulates the Growth of Human Mastocytosis Cells (2013)
  • Author(s): Kataoka TR, Fujimoto M, Moriyoshi K, Koyanagi I, Ueshima C, Kono F, Tsuruyama T, Okayama Y, Ra C, Haga H
  • Journal Title: Allergology International Volume: 62 Issue: 1 Pages: 99-104
  • DOI: 10.2332/allergolint.12-OA-0450
  • NAID: 130004477172
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed
• [Journal Article] 抑制性受容体によるヒトマスト細胞の制御 (2012)
  • Author(s): 片岡竜貴、羽賀博典
  • Journal Title: アレルギー Volume: 61(6) Pages: 805-812
  • Peer Reviewed
• [Presentation] ヒト・マスト細胞におけるKIR2DL4の役割 (2011)
  • Author(s): 片岡 竜貴
  • Organizer: 日本アレルギー学会総会
  • Place of Presentation: 東京（品川）