Development of invasion and/or metastasis of pancreatic and lung cancers by controlling S100A4
Project/Area Number |
23590452
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Experimental pathology
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Research Institution | Tohoku University |
Principal Investigator |
HORII Akira 東北大学, 医学(系)研究科(研究院), 教授 (40249983)
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | S100A4 / 膵癌 / 肺癌 / 神経浸潤 / 薬剤耐性 / 浸潤 / 転移 / メチル化 / ヒストン修飾 / Gemcitabine耐性 |
Research Abstract |
Overexpression of S100A4 is frequently found in pancreatic and lung cancers. Knockdown suppresses cell growth and forced expression promotes cell motility in both of the cancer types. Furthermore, we analyzed primary resected pancreatic cancer tissues immunohistochemically and found positive association between overexpression of S100A4 and tumor cell invasion, particularly to nerves. Microarray analyses after forced expression in S100A4-low expressing cells identified candidate downstream genes and we are now analyzing functions of these genes. Because overexpression of S100A4 and poor prognoses after gemcitabine treatment was reported in pancreatic cancer, we established 8 cancer cell lines with acquired gemcitabine resistance; these include four pancreatic, one gastric, one colon, one gallbladder, one bile duct cancers. Frequent inactivating mutation in deoxycytidine kinase was observed, and further investigation is on the way.
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Report
(4 results)
Research Products
(63 results)
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[Journal Article] Loss of NDRG2 expression activates PI3K-AKT signalling via PTEN phosphorylation in ATLL and other cancers.2014
Author(s)
Nakahata S, Ichikawa T, Maneesaay P, Saito Y, Nagai K, Tamura T, Manachai N, Yamakawa N, Hamasaki M, Kitabayashi I, Arai Y, Kanai Y, Taki T, Abe T, Kiyonari H, Shimoda K, Ohshima K, Horii A, Shima H, Taniwaki M, Yamaguchi R, Morishita K.
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Journal Title
Nat Commun
Volume: in press
Issue: 1
Pages: 3393-3393
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] New screening methods for probiotics with adhesion properties to sialic acid and sulfate residues in human colonic mucin using the Biacore assay.2013
Author(s)
Huang I-N, Okawara, T, Watanabe M, Kawai Y, Kitazawa H, Ohnuma S, Shibata C, Horii A, Kimura K, Taketomo N, Xiao J, Iwatsuki K, Saito T.
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Journal Title
J Appl Microbiol
Volume: 114
Issue: 3
Pages: 854-860
DOI
Related Report
Peer Reviewed
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[Journal Article] The expression of S100A4 in human pancreatic cancer is associated with invasion.2013
Author(s)
Tsukamoto N, Egawa S, Akada M, Abe K, Saiki Y, Kaneko N, Yokoyama S, Shima K, Yamamura A, Motoi F, Abe H, Hayashi H, Ishida K, Moriya T, Tabata T,Sunamura M, Unno M, Horii A, et al.
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Journal Title
Pancreas
Volume: in press
Related Report
Peer Reviewed
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[Journal Article] S100A4, frequently overexpressed in various human cancers, accelerates cell motility in pancreatic cancercells2012
Author(s)
Sekine H, Chen N, Sato K, Saiki Y, Yoshino Y, Umetsu Y, Jin G, Nagase H, Gu Z, Fukushige S, Sunamura M, Horii A.
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Journal Title
Biochem Biophys Res Commun
Volume: 429
Issue: 3-4
Pages: 214-219
DOI
Related Report
Peer Reviewed
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[Journal Article] An Adhesin-Like Protein, Lam29, from <i>Lactobacillus mucosae</i> ME-340 Binds to Histone H3 and Blood Group Antigens in Human Colonic Mucus2012
Author(s)
Watanabe M, Kinoshita H, Huang IN, Eguchi K, Tsurumi T, Kawai Y, Kitazawa H, Kimura K, Taketomo N, Kikuchi D, Sase T, Miura K, Ogawa H, Shibata C, Horii A, Saito T.
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Journal Title
Bioscience, Biotechnology, and Biochemistry
Volume: 76
Issue: 9
Pages: 1655-1660
DOI
NAID
ISSN
0916-8451, 1347-6947
Related Report
Peer Reviewed
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[Journal Article] miR-34a is downregulated in cis-diamminedichloroplatinum treated sinonasal squamous cell carcinoma patients with poor prognosis2012
Author(s)
Ogawa T, Saiki Y, Shiga K, Chen N, Fukushige S, Sunamura M, Nagase H, Hashimoto S, Matsuura K, Saijo S, Kobayashi T, Horii A.
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Journal Title
Cancer Sci
Volume: 103
Issue: 9
Pages: 1737-1743
DOI
Related Report
Peer Reviewed
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[Journal Article] Methylation of death-associated protein kinase (DAPK) is associated with cetuximab and erlotinib resistance2012
Author(s)
Ogawa T, Liggett TE, Melnikov AA, Monitto CL, Kusuke D, Shiga K, Kobayashi T, Horii A, Chattejee A, Levenson VV, Koch W, Sidransky D, Chang X
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Journal Title
Cell Cycle
Volume: 11
Issue: 8
Pages: 1655-1662
DOI
Related Report
Peer Reviewed
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[Presentation] IFI27 and NOV, downstream regulated genes by S100A4, are playing important roles in pancreatic carcinogenesis2014
Author(s)
Chen N, Saiki Y, Sekine H, Sunamura M, Fukushige S, Motoi F, Egawa S, Unno M, Horii A
Organizer
アメリカ癌学会
Place of Presentation
アメリカ・サンディエゴ
Related Report
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[Presentation] IFI27 and NOV, downstream regulated genes by S100A4, are playing important roles in pancreatic carcinogenesis.2014
Author(s)
Na Chen, Yuriko Saiki, Hitoshi Sekine, Makoto Sunamura, Shinichi Fukushige, Fuyuhiko Motoi, Shinichi Egawa, Michiaki Unno, Akira Horii
Organizer
American Association for Cancer Research Annual Meeting
Place of Presentation
San Diego、アメリカ合衆国
Related Report
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[Presentation] Suppressed NDRG2 expression correlates with poor prognosis in pancreatic cancer, and suppression mechanism is different from colorectal and gastric cancer2013
Author(s)
Mizuguchi Y, Yamamura A, Miura K, Karasawa H, Morishita K, Abe K, Saiki Y, Fukushige S, Kaneko N, Sase T, Motoi F, Egawa S, Shibata C, Unno M, Sasaki I, Horii A
Organizer
日本癌学会-アメリカ癌学会合同会議
Place of Presentation
アメリカ・マウイ島
Related Report
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[Presentation] Suppressed NDRG2 expression correlates with poor prognosis in pancreatic cancer, and the suppression mechanisms are distinct from that of colorectal and gastric cancers.2013
Author(s)
Mizuguchi Y, Yamamura A, Miura K, Karasawa H, Morishita K, Saiki Y, Fukushige S, Motio F, Egawa S, Shibata C, Unno M, Horii A.
Organizer
Ninth AACR-Japanese Cancer Association Joint Conference
Place of Presentation
Maui, HI, USA
Related Report
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[Presentation] New prevention strategy for inflammatory bowel disease using probiotic lactic acid bacteria and/or Bifidobacterium with specific adhesion to human intestine2011
Author(s)
Saito T, Yukishita R, Watanabe M, Katazawa H, Kawai Y, Horii A, Ikezawa F, Yamamura A, Ogawa H, Miura K, Shibata C, Sasaki I
Organizer
Lactic Acid Bacteriaシンポジウム
Place of Presentation
ニュージーランド・エグモントアーンゼー
Related Report
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[Presentation] New prevention strategy for inflammatory bowel disease using probiotic lactic acid bacteria and/or Bifidobacterium with specific adhesion to human intestine2011
Author(s)
Saito T, Yukishita R, Watanabe M, Katazawa H, Kawai Y, Horii A, Ikezawa F, Yamamura A, Ogawa H, Miura K, Shibata C, Sasaki I.
Organizer
The 10th Symposium on Lactic Acid Bacteria
Place of Presentation
Egmond aan Zee, the Netherlands
Related Report
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