Role of miRNA on tumor-stromal interaction in the pancreas
| Project/Area Number |
23590469
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Nagoya City University |
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Principal Investigator |
FUKAMACHI Katsumi 名古屋市立大学, 医学(系)研究科(研究院), 講師 (90381798)
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| Co-Investigator(Renkei-kenkyūsha) |
TSUDA Hiroyuki 名古屋市立大学, その他部局, 教授 (10163809)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 膵癌 / 膵がん |
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| Outline of Final Research Achievements |
Pancreatic ductal adenocarcinoma is an extreamly stroma-rich and highly aggressive solid tumor. We established an animal model for human pancreatic ductal adenocarcinoma using transgenic rats in which expression of a human KRAS oncogene is regulated by the Cre/loxP system. Using this model, we searched for candidate extracellular miRNAs for participating in the stroma formation in pancreatic cancer. Many miRNAs showed different expression patterns between tumor tissue and serum of rats bearing pancreatic ductal adenocrcinoma. It is suggest that the some kind of sorted miRNAs were secreted to extracellular. These miRNA might be involved in the stroma formation.
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Report
(5 results)
Research Products
(8 results)
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[Journal Article] Twenty-one proteins up-regulated in human H-ras oncogene transgenic rat pancreas cancers are up-regulated in human pancreas cancer2013
Author(s)
Yabushita S., Fukamachi K., Kikuchi F., Ozaki M., Miyata K., Sukata T., Deguchi Y., Tanaka H., Kakehashi A., Kawamura S., Uwagawa S., Wanibuchi H., Suzui M., Alexander D.B., Tsuda H.
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Journal Title
Pancreas
Volume: 42
Issue: 6
Pages: 1034-1039
DOI
Related Report
Peer Reviewed
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[Journal Article] Metabolomic and transcriptomic profiling of human K-ras oncogene transgenic rats with pancreatic ductal adenocarcinomas2013
Author(s)
Yabushita S., Fukamachi K., Tanaka H., Fukuda T., Sumida K., Deguchi Y., Mikata K., Nishioka K., Kawamura S., Uwagawa S., Suzui M., Alexander D.B., Tsuda H.
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Journal Title
Carcinogenesis
Volume: 34
Issue: 6
Pages: 1251-1259
DOI
Related Report
Peer Reviewed
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