Identification of Pancreatic Cancer Stem Cells and Development of Novel Therapeutic Strategies using Stem Cell Markers
| Project/Area Number |
23590477
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Nippon Medical School |
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Principal Investigator |
NAITO Zenya 日本医科大学, 医学(系)研究科(研究院), 教授 (20237184)
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| Co-Investigator(Renkei-kenkyūsha) |
ISHIWATA Toshiyuki 日本医科大学, 医学部, 准教授 (90203041)
MATSUDA Yoko 日本医科大学, 医学部, 講師 (20363187)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 癌幹細胞 / 膵癌 / 前癌病変 / 癌幹細胞マーカー |
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| Research Abstract |
The cancer stem cell markers for human pancreatic ductal adenocarcinoma are expressed in precancerous lesions, PanIN and IPMNs. The expression levels had increased strongly higher dysplasia in the precancerous lesions and marked overexpression was observed in adenocarcinomas. The CD133 overexpression in adenocarcinoma correlated with venous invasion. CD24, ESA and CXCR4 expressions in adenocarcinomas were related with well-differentiated types. The Ki-67 and MCM2 labeling indices of the cell proliferation markers was greater in higher grade precancerous lesions compered to low grade precancerous lesions, and increased markedly in carcinoma in situ and in invasive lesions. The newly ductal adenocarcinoma cell line that we established showed an overexpression of CXCR4. This cell line and 2 adenosquamous cell lines showed high levels of expression of ESA and MCM2. These cell lines were not tumorgenic in nude mice.
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Report
(4 results)
Research Products
(52 results)
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[Journal Article] Overexpressed fibroblast growth factor receptor 2 in the invasive front of colorectal cancer as a potential therapeutic target of colorectal cancer2011
Author(s)
Mastuda Y, Ishiwata T, Yamahatsu K, Kawahara K, Hagio M, Peng WX, Yamamoto T, Nakazawa N, Seya T, Ohaki Y, Naito Z.
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Journal Title
Cancer Letters
Volume: 309
Issue: 2
Pages: 209-19
DOI
Related Report
Peer Reviewed
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[Presentation] Inhibition of Phosphorylation of Nestin Decrease Pancreatic Cancer Cell Growth2013
Author(s)
Matsuda Y, Yoshimura H, Suzuki T, Naito Z, Kawahara K, Yanagisawa Y, Kawamoto Y, Ishiwata T
Organizer
American association for cancer research, 104th annual meeting 2013, AACR
Place of Presentation
Washington, DC
Year and Date
2013-04-09
Related Report
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[Presentation] Inhibition of Nestin Using siRNA as a Novel Therapeutic Option for Pancreatic Cancer2013
Author(s)
Ishiwata T, Yoshimura H, Suzuki T, Yanagisawa Y, Kawamoto Y, Kawahara K, Naito Z, Korc M, Matsuda Y
Organizer
American association for cancer research, 104th annual meeting 2013, AACR
Place of Presentation
Washington, DC
Year and Date
2013-04-07
Related Report
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[Presentation] Inhibition of Nestin Using siRNA as a Novel Therapeutic Option for Pancreatic Cancer2013
Author(s)
Ishiwata T, Yoshimura H, Suzuki T, Yanagisawa Y, Kawamoto Y, Kawahara K, Naito Z, Korc M, Matsuda Y
Organizer
American association for cancer research, 104th annual meeting
Place of Presentation
Washington,DC USA
Related Report
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[Presentation] Expression of Cancer Stem Cell Markers in Pancreatic Ductal Adenocarcinomas and Pancreatic Intraepithelial Neoplasias2012
Author(s)
Kure S, Matsuda Y, Hagio M, Suzuki T, Ueda J, Yamahatsu K, Yamamoto T, Ishiwata T, Naito Z
Organizer
American association for cancer research, 103rd annual meeting 2012, AACR
Place of Presentation
Chicago, IL
Year and Date
2012-04-01
Related Report
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[Presentation] Expression of Cancer Stem Cell Markers in Pancreatic Ductal Adenocarcinomas and Pancreatic Intraepithelial Neoplasias.2012
Author(s)
S Kure, Y Matsuda, M Hagio, T Suzuki, J Ueda, K Yamahastu, T Yamamoto, T Ishiwata, Z Naito
Organizer
American association for cancer research (103rd annual meeting 2012)
Place of Presentation
Chicago, IL, USA
Related Report
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