| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
We showed the possibility of the presence of IL-18-induced metastasis inhibitory factor(s) in the previous paper. The purpose of this research is to identify the factor(s) and to clarify its metastasis suppression mechanism. We revealed that this factor mainly existed in serum. We found 32 candidates of the factor(s) using the antibody arrays. As a result of investigating the metastasis suppressing activity of five factors with high expression level, three of them inhibited the tumor cell invasion. Further, we found 42 candidates of the factor(s) through two-dimensional electrophoresis and the MALDI-TOF-MS.
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