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Effect of a potential Chlamydial effecter protein, CpB0850 on cell cycle progression of host cells

Research Project

Project/Area Number 23590505
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Bacteriology (including Mycology)
Research InstitutionUniversity of the Ryukyus (2013)
Osaka University (2011-2012)

Principal Investigator

HIRAI Itaru  琉球大学, 医学部, 教授 (00359994)

Co-Investigator(Kenkyū-buntansha) YAMAMOTO Yoshimasa  大阪府立公衆衛生研究所, 所長 (20010100)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords遺伝子 / 細菌 / 微生物 / 肺炎クラミジア / 細胞周期
Research Abstract

In this study, we examined effect of Chlamydophila pneumoniae infection on host cells. Cell growth of host cells were suppressed by C. pneumoniae infection through modification of certain signal transduction pathway. In addition, it was suggested that a potential Chlamydial effector protein, CpB0850 might effect on cell cycle progression through interaction with host cellular chromosomal protein.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (33 results)

All 2014 2013 2012 2011

All Journal Article (27 results) (of which Peer Reviewed: 27 results) Presentation (6 results)

  • [Journal Article] Detection of chromosomal blaCTX-M-15 in Escherichia coli O25b-B2-ST131 isolates from the Kinki region of Japan2013

    • Author(s)
      Hirai I, Fukui N, Taguchi M, Yamauchi K, Nakamura T, Okano S, Yamamoto Y
    • Journal Title

      Int J Antimicrob Agents

      Volume: 42(6) Pages: 500-6

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fecal carriage of CTX-Mβ-lactamase-producing Enterobacteriaceae in nursing homes in the Kinki region of Japan2013

    • Author(s)
      Luvsansharav UO, Hirai I, Niki M, Nakata A, Yoshinaga A, Yamamoto A, Yamamoto M, Toyoshima H, Kawakami F, Matsuura N, Yamamoto Y
    • Journal Title

      Infect Drug Resist

      Volume: 22;6 Pages: 67-70

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dengue virus neutralization and antibody-dependent enhancement activities of human monoclonal antibodies derived from dengue patients at acute phase of secondary infection2013

    • Author(s)
      Sasaki T, Setthapramote C, Kurosu T, Nishimura M, Asai A, Omokoko MD, Pipattanaboon C, Pitaksajjakul P, Limkittikul K, Subchareon A, Chaichana P, Okabayashi T, Hirai I, Leuangwutiwong P, Misaki R, Fujiyama K, Ono KI, Okuno Y, Ramasoota P, Ikuta K
    • Journal Title

      Antiviral Res

      Volume: 98(3) Pages: 423-31

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chlamydophila pneumoniae in human immortal Jurkat cells and primary lymphocytes uncontrolled by interferon-γ2013

    • Author(s)
      Ishida K, Kubo T, Saeki A, Yamane C, Matsuo J, Yimin, Nakamura S, Hayashi Y, Kunichika M, Yoshida M, Takahashi K, Hirai I, Yamamoto Y, Shibata K, Yamaguchi H
    • Journal Title

      Microbes Infect

      Volume: 15(3) Pages: 192-200

    • NAID

      120005228354

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Jurkat cell proliferation is suppressed by Chlamydia (Chlamydophila) pneumoniae infection accompanied with attenuation of phosphorylation at Thr389 of host cellular p70S6 K2013

    • Author(s)
      Hirai I, Ebara M, Nakanishi M, Yamamoto C, Sasaki T, Ikuta K, Yamamoto Y
    • Journal Title

      Immunobiology

      Volume: 218(4) Pages: 527-532

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Human monoclonal antibodies to neutralize all dengue virus serotypes using lymphocytes from patients at acute phase of the secondary infection2013

    • Author(s)
      Setthapramote C, Sasaki T, Puiprom O, Limkittikul K, Pitaksajjakul P, Pipattanaboon C, Sasayama M, Leuangwutiwong P, Phumratanaprapin W, Chamnachanan S, Kusolsuk T, Jittmittraphap A, Asai A, Arias JF, Hirai I, Kuhara M, Okuno Y, Kurosu T, Ramasoota P, Ikuta K
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 432(1) Pages: 200-1

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Detection of chromosomal blaCTX-M-15 in Escherichia coli O25b-B2-ST131 isolates from the Kinki region of Japan.2013

    • Author(s)
      Hirai I, Fukui N, Taguchi M, Yamauchi K, Nakamura T, Okano S, Yamamoto Y.
    • Journal Title

      Int J Antimicrob Agents.

      Volume: 42(6) Issue: 6 Pages: 500-506

    • DOI

      10.1016/j.ijantimicag.2013.08.005

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fecal carriage of CTX-M β-lactamase-producing Enterobacteriaceae in nursing homes in the Kinki region of Japan.2013

    • Author(s)
      Luvsansharav UO, Hirai I, Niki M, Nakata A, Yoshinaga A, Yamamoto A, Yamamoto M, Toyoshima H, Kawakami F, Matsuura N, Yamamoto Y.
    • Journal Title

      Infect Drug Resist.

      Volume: 6 Pages: 67-70

    • DOI

      10.2147/idr.s43868

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dengue virus neutralization and antibody-dependent enhancement activities of human monoclonal antibodies derived from dengue patients at acute phase of secondary infection.2013

    • Author(s)
      Sasaki T, Setthapramote C, Kurosu T, et al
    • Journal Title

      Antiviral Res.

      Volume: S0166-3542(13) Issue: 3 Pages: 72-7

    • DOI

      10.1016/j.antiviral.2013.03.018

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Chlamydophila pneumoniae in Human Immortal Jurkat cells and Primary Lymphocytes Uncontrolled by Interferon-γ2013

    • Author(s)
      Kasumi Ishida. Takeru Kubo, Ayumi Saeki, Chikayo Yamane, Junji Matsuo, Yimin, Shinji Nakamura, Yasuhiro Hayashi, Miyuki Kunichika, Mitsutaka Yoshida, Kaori Takahashi, Itaru Hirai, Yoshimasa Yamamoto, Kenichiro Shibata, Hiroyuki Yamaguchi
    • Journal Title

      Microbes and Infection

      Volume: 15 Issue: 3 Pages: 192-200

    • DOI

      10.1016/j.micinf.2012.11.006

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Jurkat cell proliferation is suppressed by Chlamydia (Chlamydophila) pneumoniae infection accompanied with attenuation of phosphorylation at Thr389 of host cellular p70S6K.2013

    • Author(s)
      Hirai I, Ebara M, Nakanishi S, Yamamoto C, Sasaki T, Ikuta K, Yamamoto Y.
    • Journal Title

      Immunobiology.

      Volume: 218(4) Issue: 4 Pages: 527-532

    • DOI

      10.1016/j.imbio.2012.06.008

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prevalence of and risk factors associated with fecal carriage of CTX-Mβ-lactamase-producing Enterobacteriaceae in rural Thai communities2012

    • Author(s)
      Luvsansharav UO, Hirai I, Nakata A, Imura K, Yamauchi K, Niki M, Komalamisra C, Kusolsuk T, Yamamoto Y
    • Journal Title

      J Antimicrob Chemother

      Volume: 67(7) Pages: 1769-74

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chlamydia trachomatis serovar L2 infection model using human lymphoid Jurkat cells2012

    • Author(s)
      Kubo T, Ishida K, Matsuo J, Nakamura S, Hayashi Y, Sakai H, Yoshida M, Takahashi K, Hirai I, Yamamoto Y, Yamaguchi Y
    • Journal Title

      Microb Pathog

      Volume: 53(1) Pages: 1-11

    • NAID

      120005946711

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Epidemiology of Escherichia coli, Klebsiella Species, and Proteus mirabilis Strains Producing Extended-Spectrumβ-Lactamases From Clinical Samples in the Kinki Region of Japan2012

    • Author(s)
      Nakamura T, Komatsu M, Yamasaki K, Fukuda S, Miyamoto Y, Higuchi T, Ono T, Nishio H, Sueyoshi N, Kida K, Satoh K, Toda H, Toyokawa M, Nishi I, Sakamoto M, Akagi M, Nakai I, Kofuku T, Orita T, Wada Y, Zikimoto T, Koike C, Kinoshita S, Hirai I, Takahashi H, Matsuura N, Yamamoto Y
    • Journal Title

      Am J Clin Pathol

      Volume: 137(4) Pages: 620-6

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Human monoclonal antibodies to neutralize all dengue virus serotypes using lymphocytes from patients at acute phase of the secondary infection.2012

    • Author(s)
      Setthapramote C, Sasaki T, Puiprom O, et al.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 423(4) Issue: 4 Pages: 867-872

    • DOI

      10.1016/j.bbrc.2012.06.057

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Chlamydia trachomatis serovar L2 Infection Model Using Human Lymphoid Jurkat cells.2012

    • Author(s)
      Takeru Kubo, Kasumi Ishida. Junji Matsuo, Shinji Nakamura, Yasuhiro Hayashi, Haruna Sakai, Mitsutaka Yoshida, Kaori Takahashi, Itaru Hirai, Yoshimasa Yamamoto, Hiroyuki
    • Journal Title

      Microbial Pathogenesis

      Volume: 53 Issue: 1 Pages: 41-285

    • DOI

      10.1016/j.micpath.2012.02.005

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prevalence of and risk factors associated with faecal carriage of CTX-M beta-lactamase-producing Enterobacteriaceae in rural Thai communities2012

    • Author(s)
      Ulzii-Orshikh Luvsansharav
    • Journal Title

      Journal of Antimicrobial Chemotherapy

      Volume: 67 Issue: 7 Pages: 1769-1774

    • DOI

      10.1093/jac/dks118

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Epidemiology of Escherichia coli, Klebsiella species, and Proteus mirabilis strains producing extended-spectrum β-lactamases from clinical samples in the Kinki Region of Japan.2012

    • Author(s)
      Nakamura T, Komatsu M, Yamasaki K, et al.
    • Journal Title

      Am J Clin Pathol.

      Volume: 137(4) Issue: 4 Pages: 620-626

    • DOI

      10.1309/ajcp48pdvkwqoxez

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Extended-spectrumβ-lactamase-producing Escherichia coli strains in the feces of carriers contribute substantially to urinary tract infections in these patients2011

    • Author(s)
      Niki M, Hirai I, Yoshinaga A, Ulzii-Orshikh L, Nakata A, Yamamoto A, Yamamoto M, Yamamoto Y
    • Journal Title

      Infection

      Volume: 39(5) Pages: 467-71

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 医療系学生における基質特異性拡張型βラクタマーゼ産生腸内細菌保持率2011

    • Author(s)
      仁木真理恵,平井到,山本容正
    • Journal Title

      日本環境感染学会誌

      Volume: 26(3) Pages: 154-156

    • NAID

      10030236799

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chlamydophila pneumoniae attachment and infection in low proteoglycan expressing human lymphoid Jurkat cells2011

    • Author(s)
      Kobayashi M, Ishida K, Matsuo J, Nakamura S, Nagasawa A, Motohashi K, Yao T, Hirai I, Yamamoto Y, Suzuki H, Shimizu C, Matsuno K, Yamaguchi H
    • Journal Title

      Microb Pathog

      Volume: 51(3) Pages: 209-16

    • NAID

      120003295071

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of risk factors for a high prevalence of extended-spectrumβ-lactamase-producing Enterobacteriaceae in asymptomatic individuals in rural Thailand2011

    • Author(s)
      Luvsansharav UO, Hirai I, Niki M, Sasaki T, Makimoto K, Komalamisra C, Maipanich W, Kusolsuk T, Sa-Nguankiat S, Pubampen S, Yamamoto Y
    • Journal Title

      J Med Microbiol

      Volume: 60(Pt 5) Pages: 619-24

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prevalence of fecal carriage of extended-spectrumβ-lactamase-producing Enterobacteriaceae among healthy adult people in Japan2011

    • Author(s)
      Luvsansharav UO, Hirai I, Niki M, Nakata A, Yoshinaga A, Moriyama T, Yamamoto Y
    • Journal Title

      J Infect Chemother

      Volume: 17(5) Pages: 722-5

    • NAID

      10030225576

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of risk factors for a high prevalence of extended-spectrum {beta}-lactamase-producing Enterobacteriaceae in asymptomatic individuals in rural Thailand.2011

    • Author(s)
      Luvsansharav UO, Hirai I, Niki M, Sasaki T, Makimoto K, Komalamisra C, Maipanich W, Kusolsuk T, Sa-Nguankiat S, Pubampen S, Yamamoto Y.
    • Journal Title

      J Med Microbiol.

      Volume: 60 Issue: 5 Pages: 619-624

    • DOI

      10.1099/jmm.0.026955-0

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prevalence of fecal carriage of extended-spectrum β-lactamase-producing Enterobacteriaceae among healthy adult people in Japan.2011

    • Author(s)
      Luvsansharav UO, Hirai I, Niki M, Nakata A, Yoshinaga A, Moriyama T, Yamamoto Y.
    • Journal Title

      J Infect Chemother

      Volume: 17 Issue: 5 Pages: 722-725

    • DOI

      10.1007/s10156-011-0225-2

    • NAID

      10030225576

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Chlamydophila pneumoniae attachment and infection in low proteoglycan expressing human lymphoid Jurkat cells.2011

    • Author(s)
      Kobayashi M, Ishida K, Matsuo J, Nakamura S, Nagasawa A, Motohashi K, Yao T, Hirai I, Yamamoto Y, Suzuki H, Shimizu C, Matsuno K, Yamaguchi H.
    • Journal Title

      Microb Pathog.

      Volume: 51 Issue: 3 Pages: 209-216

    • DOI

      10.1016/j.micpath.2011.03.010

    • NAID

      120003295071

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Extended-spectrum β-lactamase-producing Escherichia coli strains in the feces of carriers contribute substantially to urinary tract infections in these patients.2011

    • Author(s)
      Niki M, Hirai I, Yoshinaga A, Ulzii-Orshikh L, Nakata A, Yamamoto A, Yamamoto M, Yamamoto Y.
    • Journal Title

      Infection

      Volume: 39 Issue: 5 Pages: 467-471

    • DOI

      10.1007/s15010-011-0128-2

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Dissemination of CTX-M type ESBL-producing bacteria in Southeast Asian countries2014

    • Author(s)
      Itaru Hirai
    • Organizer
      第87回日本細菌学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] High Prevalence of Extended Spectrumβ-lactamase-producing Escherichia coli in Household Members of a Rural Area in Vietnam2013

    • Author(s)
      H. Bui, I. Hirai, T. Nguyen, V. Ha, N. Bui, H. Phan, T. Le, S. Ueda, H. Watabe, H. Le, Y. Yamamoto
    • Organizer
      53rd ICAAC
    • Place of Presentation
      Denver, CO
    • Related Report
      2013 Final Research Report
  • [Presentation] 健常人由来CTX-M型ESBL産生菌株におけるESBL遺伝子の存在形態と地理的分布の関連性2013

    • Author(s)
      平井到,山内紘,山本容正
    • Organizer
      第86回日本西院学会総会
    • Place of Presentation
      千葉市
    • Related Report
      2013 Final Research Report
  • [Presentation] A sequencing analysis of genetic environment surrounding blaCTX-M-15 in Escherichia coli2012

    • Author(s)
      Naoki Fukui, Itaru Hirai, Arisa Nakata, Aya Yoshinaga, Ulzii-Orshikh Luvsansharav, Tatsuya Nakamura, Yoshimasa Yamamoto
    • Organizer
      第85回日本細菌学会総会
    • Place of Presentation
      長崎市
    • Related Report
      2013 Final Research Report
  • [Presentation] A 2-year trend of CTX-M beta-lactamase-producing Enterobacteriaceae in asymptomatic Thai people2012

    • Author(s)
      Ulzii-Orshikh Luvsansharav, Itaru Hirai, Arisa Nakata, Kaori Imura, Kou Yamauchi, Marie Niki, Chalit Komalamisra, Teera Kusolsuk, Yoshimasa Yamamoto
    • Organizer
      第85回日本細菌学会総会
    • Place of Presentation
      長崎市
    • Related Report
      2013 Final Research Report
  • [Presentation] CELL DIVISION OF INFECTED CELLS IS RETARDED BY SECRETION OF A NOVEL EFFECTER PROTEIN, CPB0850, OF CHLAMYDIA (CHLAMYDOPHILA) PNEUMONIAE2011

    • Author(s)
      Itaru Hirai, Masanori Matsuba, Yoshimasa Yamamoto
    • Organizer
      The IUMS 2011 Sapporo Congress
    • Place of Presentation
      札幌
    • Related Report
      2013 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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