Effect of a potential Chlamydial effecter protein, CpB0850 on cell cycle progression of host cells
Project/Area Number |
23590505
|
Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Bacteriology (including Mycology)
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Research Institution | University of the Ryukyus (2013) Osaka University (2011-2012) |
Principal Investigator |
HIRAI Itaru 琉球大学, 医学部, 教授 (00359994)
|
Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Yoshimasa 大阪府立公衆衛生研究所, 所長 (20010100)
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 遺伝子 / 細菌 / 微生物 / 肺炎クラミジア / 細胞周期 |
Research Abstract |
In this study, we examined effect of Chlamydophila pneumoniae infection on host cells. Cell growth of host cells were suppressed by C. pneumoniae infection through modification of certain signal transduction pathway. In addition, it was suggested that a potential Chlamydial effector protein, CpB0850 might effect on cell cycle progression through interaction with host cellular chromosomal protein.
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] Fecal carriage of CTX-Mβ-lactamase-producing Enterobacteriaceae in nursing homes in the Kinki region of Japan2013
Author(s)
Luvsansharav UO, Hirai I, Niki M, Nakata A, Yoshinaga A, Yamamoto A, Yamamoto M, Toyoshima H, Kawakami F, Matsuura N, Yamamoto Y
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Journal Title
Infect Drug Resist
Volume: 22;6
Pages: 67-70
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Peer Reviewed
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[Journal Article] Dengue virus neutralization and antibody-dependent enhancement activities of human monoclonal antibodies derived from dengue patients at acute phase of secondary infection2013
Author(s)
Sasaki T, Setthapramote C, Kurosu T, Nishimura M, Asai A, Omokoko MD, Pipattanaboon C, Pitaksajjakul P, Limkittikul K, Subchareon A, Chaichana P, Okabayashi T, Hirai I, Leuangwutiwong P, Misaki R, Fujiyama K, Ono KI, Okuno Y, Ramasoota P, Ikuta K
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Journal Title
Antiviral Res
Volume: 98(3)
Pages: 423-31
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Peer Reviewed
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[Journal Article] Chlamydophila pneumoniae in human immortal Jurkat cells and primary lymphocytes uncontrolled by interferon-γ2013
Author(s)
Ishida K, Kubo T, Saeki A, Yamane C, Matsuo J, Yimin, Nakamura S, Hayashi Y, Kunichika M, Yoshida M, Takahashi K, Hirai I, Yamamoto Y, Shibata K, Yamaguchi H
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Journal Title
Microbes Infect
Volume: 15(3)
Pages: 192-200
NAID
Related Report
Peer Reviewed
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[Journal Article] Human monoclonal antibodies to neutralize all dengue virus serotypes using lymphocytes from patients at acute phase of the secondary infection2013
Author(s)
Setthapramote C, Sasaki T, Puiprom O, Limkittikul K, Pitaksajjakul P, Pipattanaboon C, Sasayama M, Leuangwutiwong P, Phumratanaprapin W, Chamnachanan S, Kusolsuk T, Jittmittraphap A, Asai A, Arias JF, Hirai I, Kuhara M, Okuno Y, Kurosu T, Ramasoota P, Ikuta K
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Journal Title
Biochem Biophys Res Commun
Volume: 432(1)
Pages: 200-1
Related Report
Peer Reviewed
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[Journal Article] Fecal carriage of CTX-M β-lactamase-producing Enterobacteriaceae in nursing homes in the Kinki region of Japan.2013
Author(s)
Luvsansharav UO, Hirai I, Niki M, Nakata A, Yoshinaga A, Yamamoto A, Yamamoto M, Toyoshima H, Kawakami F, Matsuura N, Yamamoto Y.
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Journal Title
Infect Drug Resist.
Volume: 6
Pages: 67-70
DOI
Related Report
Peer Reviewed
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[Journal Article] Chlamydophila pneumoniae in Human Immortal Jurkat cells and Primary Lymphocytes Uncontrolled by Interferon-γ2013
Author(s)
Kasumi Ishida. Takeru Kubo, Ayumi Saeki, Chikayo Yamane, Junji Matsuo, Yimin, Shinji Nakamura, Yasuhiro Hayashi, Miyuki Kunichika, Mitsutaka Yoshida, Kaori Takahashi, Itaru Hirai, Yoshimasa Yamamoto, Kenichiro Shibata, Hiroyuki Yamaguchi
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Journal Title
Microbes and Infection
Volume: 15
Issue: 3
Pages: 192-200
DOI
Related Report
Peer Reviewed
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[Journal Article] Chlamydia trachomatis serovar L2 infection model using human lymphoid Jurkat cells2012
Author(s)
Kubo T, Ishida K, Matsuo J, Nakamura S, Hayashi Y, Sakai H, Yoshida M, Takahashi K, Hirai I, Yamamoto Y, Yamaguchi Y
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Journal Title
Microb Pathog
Volume: 53(1)
Pages: 1-11
NAID
Related Report
Peer Reviewed
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[Journal Article] Epidemiology of Escherichia coli, Klebsiella Species, and Proteus mirabilis Strains Producing Extended-Spectrumβ-Lactamases From Clinical Samples in the Kinki Region of Japan2012
Author(s)
Nakamura T, Komatsu M, Yamasaki K, Fukuda S, Miyamoto Y, Higuchi T, Ono T, Nishio H, Sueyoshi N, Kida K, Satoh K, Toda H, Toyokawa M, Nishi I, Sakamoto M, Akagi M, Nakai I, Kofuku T, Orita T, Wada Y, Zikimoto T, Koike C, Kinoshita S, Hirai I, Takahashi H, Matsuura N, Yamamoto Y
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Journal Title
Am J Clin Pathol
Volume: 137(4)
Pages: 620-6
Related Report
Peer Reviewed
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[Journal Article] Chlamydophila pneumoniae attachment and infection in low proteoglycan expressing human lymphoid Jurkat cells2011
Author(s)
Kobayashi M, Ishida K, Matsuo J, Nakamura S, Nagasawa A, Motohashi K, Yao T, Hirai I, Yamamoto Y, Suzuki H, Shimizu C, Matsuno K, Yamaguchi H
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Journal Title
Microb Pathog
Volume: 51(3)
Pages: 209-16
NAID
Related Report
Peer Reviewed
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[Journal Article] Analysis of risk factors for a high prevalence of extended-spectrumβ-lactamase-producing Enterobacteriaceae in asymptomatic individuals in rural Thailand2011
Author(s)
Luvsansharav UO, Hirai I, Niki M, Sasaki T, Makimoto K, Komalamisra C, Maipanich W, Kusolsuk T, Sa-Nguankiat S, Pubampen S, Yamamoto Y
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Journal Title
J Med Microbiol
Volume: 60(Pt 5)
Pages: 619-24
Related Report
Peer Reviewed
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[Journal Article] Analysis of risk factors for a high prevalence of extended-spectrum {beta}-lactamase-producing Enterobacteriaceae in asymptomatic individuals in rural Thailand.2011
Author(s)
Luvsansharav UO, Hirai I, Niki M, Sasaki T, Makimoto K, Komalamisra C, Maipanich W, Kusolsuk T, Sa-Nguankiat S, Pubampen S, Yamamoto Y.
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Journal Title
J Med Microbiol.
Volume: 60
Issue: 5
Pages: 619-624
DOI
Related Report
Peer Reviewed
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[Journal Article] Chlamydophila pneumoniae attachment and infection in low proteoglycan expressing human lymphoid Jurkat cells.2011
Author(s)
Kobayashi M, Ishida K, Matsuo J, Nakamura S, Nagasawa A, Motohashi K, Yao T, Hirai I, Yamamoto Y, Suzuki H, Shimizu C, Matsuno K, Yamaguchi H.
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Journal Title
Microb Pathog.
Volume: 51
Issue: 3
Pages: 209-216
DOI
NAID
Related Report
Peer Reviewed
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[Presentation] High Prevalence of Extended Spectrumβ-lactamase-producing Escherichia coli in Household Members of a Rural Area in Vietnam2013
Author(s)
H. Bui, I. Hirai, T. Nguyen, V. Ha, N. Bui, H. Phan, T. Le, S. Ueda, H. Watabe, H. Le, Y. Yamamoto
Organizer
53rd ICAAC
Place of Presentation
Denver, CO
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