Research Project
Grant-in-Aid for Scientific Research (C)
Anaplasma phagocytophilum is an obligatory intracellular bacterium and causes human granulocytic anaplasmosis, an emerging tick-borne infectious disease. A. phagocytophilum forms characteristic inclusions in the host cells, so called morulae, and alters the host environment for the benefit of the bacterial multiplication. In the intracellular parasitism, we found that A. phagocytophilum activates three of all ER stress sensors, inositol-requiring enzyme 1α (IRE1α), protein kinase RNA-like ER kinase (PERK) and activating transcription factor-6 (ATF6), that regulate the eukaryotic unfolded protein response. The study suggests that A. phagocytophilum manipulates host ER stress system for intracellular survival and its growth.
All 2015 2014 2013 2012 2011
All Journal Article (8 results) (of which Peer Reviewed: 8 results, Open Access: 2 results, Acknowledgement Compliant: 1 results) Presentation (17 results) (of which Invited: 3 results)
Jpn. J. Infect. Dis.
Volume: Advance Publication Issue: 5 Pages: 434-437
10.7883/yoken.jjid.2015.003
130005098926
Emerging Infectious Diseases
Volume: 20 Issue: 3 Pages: 508-509
10.3201/eid2003.131337
Volume: 19 Issue: 2 Pages: 289-292
10.3201/eid1902.120855
Volume: 19 Issue: 2 Pages: 338-340
10.3201/eid1902.120856
Journal of Veterinary Medical Science
Volume: 75 Issue: 1 Pages: 11-15
10.1292/jvms.12-0282
130001879687
Volume: 65 Pages: 79-83
Ticks Tick Borne Dis.
Volume: 2 Pages: 94-98
J. Vet. Med. Sci.
Volume: 73 Pages: 1485-1488