Study of the pathogenesis of autoimmune pancreatitis and, the relation to activation of immate immunity induced by bacteria
| Project/Area Number |
23590522
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
HARUTA Ikuko 東京女子医科大学, 医学部, 准教授 (80221513)
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| Co-Investigator(Kenkyū-buntansha) |
YAGI Junji 東京女子医科大学, 医学部, 教授 (70182300)
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| Project Period (FY) |
2011-04-28 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 自己免疫性膵炎 / IgG4関連疾患 / 自然免疫 / FliC / 自己免疫疾患 / 制御性T細胞 / 自己免疫性膵炎(AIP) / 細菌 / IgG4関連疾患(IgG4-RD) / 自己抗原 / IgG4関連腎疾患(IgG4-RKD) / 自己抗体 / 自己免疫性膵炎（AIP） / メモリーＴ細胞 / IgG4-RD（IgG4関連疾患） / 分子擬態 / 慢性炎症 / 分子相同性 |
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| Outline of Final Research Achievements |
We previously established a mouse model of AIP using chronic exposure to a commensal bacteria, Escherichia coli, leading to pancreatic inflammation, and elevation in IgG and IgG1 in serum and detection of anti-lactoferrin and anticarbonic anhydrace-II. The outer membrane fractions of E. coli were subjected to two-dimensional gel electrophoresis followed by immunoblotting against sera from the AIP model. One representative immunoreactive spot was determined using TOF/MS and Mascot search as FliC. Sera from patients with AIP had a signiticcantly higher antibody titer. Therefore, we are underway to clarify the possibility of a new diagnostic value of anti FliC-Ab titer.
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Report
(6 results)
Research Products
(32 results)
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[Journal Article] Involvement of commensal bacteria may lead to dysregulated inflammatory and autoimmune responses in a mouse model for chronic nonsuppurative destructive cholangitis2012
Author(s)
HARUTA Ikuko, KIKUCHI Ken, NAKAMURA Minoru, HIROTA Katsuhiko, KATO Hidehito, MIYAKAWA Hiroshi, SHIBATA Noriyuki, MIYAKE Yoichiro, HASHIMOTO Etsuko, SHIRATORI Keiko, YAGI Junji
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Journal Title
Journal of clinical immunology
Volume: 32(5)
Issue: 5
Pages: 1026-1037
DOI
Related Report
Peer Reviewed
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