Evaluation of a minor sialic acid as an influenza A virus receptor base on functional glycomics approach.
| Project/Area Number |
23590549
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Virology
|
|---|
| Research Institution | University of Shizuoka |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MINAMI Akira 静岡県立大学, 薬学部, 助教 (80438192)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | 細胞 / シアル酸 / N-グリコリルノイラミン酸 / インフルエンザウイルス / 受容体 / 感染 / CMP-N-アセチルノイラミン酸水酸化酵素 / Neu5Gc / CMAH / CMP-N-アセチルノイラミン酸 水酸化酵素 |
|---|
| Research Abstract |
N-glycolylneuraminic acid (Neu5Gc) is said to be one of influenza A virus (IAV) receptors. However, expression of Neu5Gc on human cells suppressed infection of most Neu5Gc-binding human IAVs and equine IAVs. Neu5Gc is exogenously incorporated into human cells from Neu5Gc-rich foods such as red meat and milk. Neu5Gc on human cells may be involved in infection defense against many IAVs.
|
Report
(4 results)
Research Products
(119 results)
-
[Journal Article] Visualization of sialidase activity in mammalian tissues and cancer detection with a novel fluorescent sialidase substrate.2014
Author(s)
Akira Minami, Tadamune Otsubo, Daisuke Ieno, Kiyoshi Ikeda, Hiroaki Kanazawa, Kosuke Shimizu, Ko Ohata, Tsunehiro Yokochi, Yuuki Horii, Hokuto Fukumoto, Risa Taguchi, Tadanobu Takahashi, Naoto Oku, Takashi Suzuki.
-
Journal Title
PLoS One
Volume: 9
Issue: 1
Pages: e81941-e81941
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
[Journal Article] Sensitive and direct detection of receptor binding specificity of highly pathogenic avian influenza A virus in clinical samples.2013
Author(s)
Tadanobu Takahashi, Tatsuya Kawakami, Takashi Mizuno, Akira Minami, Yuko Uchida, Takehiko Saito, Shigeyuki Matsui, Makoto Ogata, Taichi Usui, Nongluk Sriwilaijaroen, Hiroaki Hiramatsu, Yasuo Suzuki, Takashi Suzuki.
-
Journal Title
PLoS One
Volume: 8
Issue: 10
Pages: e78125-e78125
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
[Journal Article] Bovine milk whey for preparation of natural N-glycans : structural and quantitative analysis2012
Author(s)
Sriwilaijaroen, N., Kondo, S., Yagi, H., Hiramatsu, H., Nakakita, S., Yamada, K., Ito, H., Hirabayashi, J., Narimatsu, H., Kato, K., Suzuki, Y.
-
Journal Title
Open Glycoscience
Volume: 5
Issue: 1
Pages: 2-12
DOI
Related Report
Peer Reviewed
-
-
-
[Journal Article] A Single amino acid mutation at position 170 of human parainfluenza virus type 1 fusion glycoprotein induces obvious syncytium formation and caspase-3-dependent cell death2011
Author(s)
Takaguchi, M., Takahashi, T., Hosokawa, C., Ueyama, H., Fukushima, K., Hayakawa, T., Ttoh, K., Ikeda, K., and Suzuki, T
-
Journal Title
J. Biochem
Volume: 149
Issue: 2
Pages: 191-202
DOI
NAID
Related Report
Peer Reviewed
-
[Journal Article] Synthese of 2-deoxy-2, 3-didehydro-N-acetylneuraminic acid analogues modified by N-sulfonylamidino groups at the C-4 position and biological evaluation as inhibitors of humanparainfluenza virus type 12011
Author(s)
Nishino, R., Ikeda, K., Hayakawa, T., Takahashi, T., Suzuki, T. and Sato, M
-
Journal Title
Bioorg. Med. Chem
Volume: 19
Issue: 7
Pages: 2418-2427
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
