Analysis of structure-function relationship of mouse TLR5 with a focus on roles of LRRCT domain

Research Project

Project/Area Number	23590572
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Immunology
Research Institution	Saitama Medical University
Principal Investigator	UOZUMI Naonori 埼玉医科大学, 医学部, 講師 (70313096)
Project Period (FY)	2011 – 2013
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000) Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000) Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	免疫学 / 炎症 / 自然免疫受容体
Research Abstract	Innate immune receptors play important roles at the first line of defense against invading pathogens. Among them, Toll-like receptors, TLR, have been a focus of intense research for years. Structure-function relationship of mouse TLR4 and TLR5 was extensively analyzed by cell biological methods. Through comparisons of various phenotype of point-mutants, and chimera receptors, mouse TLR4 and TLR5 are found, unexpectedly, to be activated by distinct molecular mechanisms. Further analyses would reveal detailed mechanisms for TLR activation, and lead to development of methods to modulate TLR activation and signaling in vivo.

Report

(4 results)