Analysis of structure-function relationship of mouse TLR5 with a focus on roles of LRRCT domain
| Project/Area Number |
23590572
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Immunology
|
|---|
| Research Institution | Saitama Medical University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 免疫学 / 炎症 / 自然免疫受容体 |
|---|
| Research Abstract |
Innate immune receptors play important roles at the first line of defense against invading pathogens. Among them, Toll-like receptors, TLR, have been a focus of intense research for years. Structure-function relationship of mouse TLR4 and TLR5 was extensively analyzed by cell biological methods. Through comparisons of various phenotype of point-mutants, and chimera receptors, mouse TLR4 and TLR5 are found, unexpectedly, to be activated by distinct molecular mechanisms. Further analyses would reveal detailed mechanisms for TLR activation, and lead to development of methods to modulate TLR activation and signaling in vivo.
|
Report
(4 results)
Research Products
(4 results)
