Development of high sensitivity assay for oxytocin, peptide hormone, and its clinical application utilizing aptamer
| Project/Area Number |
23590690
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Laboratory medicine
|
|---|
| Research Institution | Showa University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
ARAKAWA Hidetoshi 昭和大学, 薬学部, 教授 (70129807)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | アプタマー / オキシトシン / アスペルガー / 臨床分析化学 / ホルモン / 臨床薬学 / 臨床検査 / アスペルガー症候群 / ペプチドホルモン / 血中濃度測定 / 精神疾患 |
|---|
| Research Abstract |
Aptamers are single strand DNA and RNA oligonucleotides binding to their target with high affinity by three-dimensional conformation of aptamers. In this study, we report development of the high sensitively assay utilizing the aptamer for oxytocin, is associated to autism spectrum. As a result, various aptamers for oxytocin were generated by using RNA and DNA on SELEX. Those aptamers for oxytocin have checked to evaluate the affinity with oxytocin.
|
Report
(4 results)
Research Products
(15 results)
