Elucidation of brain mechanism underlying stress-induced hyperalgesia
| Project/Area Number |
23590717
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pain science
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
IMBE Hiroki 和歌山県立医科大学, 医学部, 講師 (60326353)
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| Co-Investigator(Kenkyū-buntansha) |
KIMURA Akihisa 和歌山県立医科大学, 医学部, 准教授 (20225022)
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| Project Period (FY) |
2011 – 2014
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ストレス / 疼痛学 / 下行性疼痛調節系 |
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| Outline of Final Research Achievements |
It has been known that exposure to chronic stress for animal produces hyperalgesia (enhancement of nociceptive reaction). However the mechanism remains unknown. In the present study we have demonstrated that reductions of glial fibrillary acidic protein (GFAP), astrocyte-specific cytoskeletal protein, and glia glutamate transporter levels in the periaqueductal gray matter were observed in the rats with chronic stress-induced hyperalgesia and that in chronic stress group, the GFAP protein level in the rostral ventromedial medulla was positively correlated with mechanical threshold. These results have clearly shown that the glial change in descending pain modulatory system is involved in chronic stress-induced hyperalgesia.
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Report
(4 results)
Research Products
(15 results)
