The association of sub-clinical atherosclerosis and estimated glomelular filtration rate with albuminuria among general Japanese.

• Project/Area Number: 23590791
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Shiga University of Medical Science (2011, 2014); Osaka Kyoiku University (2012-2013)
• Principal Investigator: KADOTA Aya 滋賀医科大学, アジア疫学研究センター, 特任准教授 (60546068)
• Co-Investigator(Kenkyū-buntansha): UESHIMA Hirotsugu 滋賀医科大学, アジア疫学研究センター, 特任教授 (70144483) ; MIURA Katsuyuki 滋賀医科大学, 医学部, 教授 (90257452)
• Co-Investigator(Renkei-kenkyūsha): FUJIYOSHI Akira 滋賀医科大学, 医学部, 特任助教 (10567077) ; OHKUBO Takayoshi 帝京大学, 医学部, 教授 (60344652) ; KADOWAKI Sayaka 滋賀医科大学, 医学部, 客員助教 (60510344) ; SEKIKAWA Akira 滋賀医科大学, 医学部, 客員准教授 (10216525)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2011: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
• Keywords: 潜在性動脈硬化症 / 腎機能障害 / 微量アルブミン尿 / 疫学研究 / 循環器疫学 / 慢性腎臓病 / 尿中アルブミン

Outline of Final Research Achievements

We investigated to clarify the association of subclinical atherosclerosis and estimated glomelular filtration rate (eGFR) with albuminuria among general Japanese. 860 Japanese men aged 40 to 74 years were randomly selected from Kusatsu City, Japan. Carotid atherosclerosis was assessed by ultra-sonography and the baPWV were investigated using an automated machine with a standardized method. Both serum creatinine and urine albumin were measured enzymaticaly.
Both eGFR and urine albumin were related with subclinical atherosclerosis assessed by carotid atherosclerosis (IMT and plaque) and baPWV. When subclinical atherosclerosis was assessed with the combination of eGFR and urine albumin, we found that the subclinical atherosclerosis was progressed with albuminuria>=30mg/gCr even though eGFR>=60ml/min/1.72m2. In the multivariate adjusted regression model, we found that urine albumin related with the subclinical atherosclerosis independently from eGFR.

Research Products

• [Journal Article] Carotid Intima-Media Thickness and Plaque in Apparently Healthy Japanese Individuals with an Estimated 10-Year Absolute Risk of CAD Death According to the Japan Atherosclerosis Society (JAS) Guidelines 2012: The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA) (2013)
  • Author(s): Aya Kadota, Katsuyuki Miura, Tomonori Okamura, Akira Fujiyoshi, Takayoshi Ohkubo, Takashi Kadowaki, Naoyuki Takashima, Takashi Hisamatsu, Yasuyuki Nakamura, Fumiyoshi Kasagi, Hiroshi Maegawa, Atsunori Kashiwagi and Hirotsugu Ueshima for the SESSA Research Group and for the NIPPON DATA80/90 Research Group
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 20 Issue: 10 Pages: 755-766
  • DOI: 10.5551/jat.17244
  • NAID: 130004444645
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed
• [Journal Article] Carotid intima-media thickness and plaque among apparently healthy Japanese with estimated 10-year absolute risk of CAD death according to the Japan Atherosclerosis Society (JAS) Guideline 2012: the Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA) (2013)
  • Author(s): A Kadota, K Miura, T Okamura, A Fujiyoshi, T Ohkubo, T Kadowaki, N Takashima, THisamatsu, Y Nakamura, F Kasagi, H Maegawa, A Kashiwagi and H Ueshima
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: NA
  • Peer Reviewed
• [Presentation] The association of brachial-ankle Pulse Wave Velocity and estimated glomerular filtration rate with albuminuria among general Japanese. (2015)
  • Author(s): Aya Kadota, Katsuyuki Miura, Takayoshi Ohkubo, Takashi Hisamatsu, Akira Fujiyoshi, Naoyuki Takashima,Tomonori Okamura, and Hirotsugu Ueshima for the SESSA Research Group
  • Organizer: 第83回欧州動脈硬化学会
  • Place of Presentation: グラスゴー 英国
  • Year and Date: 2015-03-22 – 2015-03-25
• [Presentation] Carotid intima-media thickness and plaque among apparently healthy Japanese with estimated 10-year absolute risk of CAD death according to the Japan Atherosclerosis Society (JAS) Guideline 2012: the Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA) (2013)
  • Author(s): Aya Kadota, Katsuyuki Miura, Tomonori Okamura, Akira Fujiyoshi, Takayoshi Ohkubo, Takashi Kadowaki, Naoyuki Takashima, Takashi Hisamatsu, Yasuyuki Nakamura, Fumiyoshi Kasagi, Hiroshi Maegawa, Atsunori Kashiwagi and Hirotsugu Ueshima for the SESSA Research Group and for the NIPPON DATA80/90 Research Group
  • Organizer: 第81回欧州動脈硬化学会
  • Place of Presentation: Lyon
• [Presentation] The relationship of serum marine-derived n-3 fatty acids and carotid intima-media thickness among general Japanese men: the Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA) (2013)
  • Author(s): Aya Kadota, Akira Sekikawa, Katsuyuki Miura, Tomonori Okamura, Akira Fujiyoshi, Takashi Kadowaki, Takayoshi Ohkubo, Takashi Hisamatsu, Naoko Miyagawa, Yasuyuki Nakamura, Hiroshi Maegawa, Atsunori Kashiwagi and Hirotsugu Ueshima for the SESSA Research Group
  • Organizer: 第45回日本動脈硬化学会総会
  • Place of Presentation: 東京
• [Presentation] Subclinical atherosclerosis of carotid arteries among apparently healthy Japanese men and women: the Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA). (2012)
  • Author(s): Aya Kadota, Katsuyuki Miura, Akira Fujiyoshi, Tomonori Okamura, Hiroshi Maegawa, Takeshi Kimura, Atsunori Kashiwagi and Hirotsugu Ueshima et al.
  • Organizer: 日本循環器学会総会
  • Place of Presentation: 福岡市
• [Presentation] Subclinical atherosclerosis of carotid arteries among apparently healthy Japanese men and women: the Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA). (2012)
  • Author(s): Aya Kadota, Katsuyuki Miura, Akira Fujiyoshi, Tomonori Okamura, Hiroshi Maegawa, Takeshi Kimura, Atsunori Kashiwagi and Hirotsugu Ueshima et al.
  • Organizer: 国際動脈硬化学会
  • Place of Presentation: オーストラリア
• [Presentation] NIPPON DATA80リスクチャートを用いた冠動脈死亡絶対危険度と頸部動脈硬化所見との関連の検討：滋賀動脈硬化疫学研究the Shiga Epidemiological Study of Subclinical Atherosclerosis(SESSA)
  • Author(s): 門田文 三浦克之 藤吉朗 岡村智教 門脇崇 中村保幸 大久保孝義 高嶋直敬 鳥居さゆ希 笠置文善 前川聡 柏木厚典 上島弘嗣
  • Organizer: 日本動脈硬化学会総会(シンポジウム演題)
  • Place of Presentation: 福岡
• [Presentation] The relationship of serum marine-derived n-3 fatty acids and carotid intima-media thickness among general Japanese men: the Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA)
  • Author(s): A Kadota, A Sekikawa, K Miura, T Okamura, A Fujiyoshi, T Kadowaki, E Barinas-Mitchell, R W. Evans, T Ohkubo, T Hisamatsu, N Miyagawa, Y Nakamura, H Maegawa, A Kashiwagi and H Ueshima
  • Organizer: 米国心臓学会疫学部門総会
  • Place of Presentation: 米国