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A longitudinal study on the relation between overall sleep status and subsequent changes in serum high-sensitivity C-reactive protein

Research Project

Project/Area Number 23590817
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Public health/Health science
Research InstitutionKanazawa Medical University

Principal Investigator

NAKAMURA Koshi  金沢医科大学, 医学部, 准教授 (80422898)

Co-Investigator(Kenkyū-buntansha) NAKAGAWA Hideaki  金沢医科大学, 医学部, 教授 (00097437)
Co-Investigator(Renkei-kenkyūsha) MORIKAWA Yuko  金沢医科大学, 看護学部, 教授 (20210156)
SAKURAI Masaru  金沢医科大学, 医学部, 准教授 (90397216)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords睡眠 / 炎症 / 縦断研究 / 高感度C-反応性蛋白 / 追跡調査
Research Abstract

We investigated the relation between overall sleep status based on the global score of a partially-modified version of Pittsburgh Sleep Quality Index (PSQI) and subsequent changes in serum high-sensitivity C-reactive protein (hsCRP) in 991 middle-aged Japanese factory workers without increased and potentially pathogenic levels of inflammation (hsCRP at year 3 >= 1.0 mg/L). The subsequent changes in hsCRP after 3 years were grater in subjects with unfavorable sleep habits, defined as a PSQI global score > 5.5 points, compared with those with a normal pattern. The geometric means of hsCRP at year 3 were 0.275 mg/L and 0.242 mg/L, respectively, after adjusting for baseline hsCRP and other potential confounders (p=0.04). The multivariate-adjusted odds ratio for developing that inflammation due to unfavorable sleep was 2.08 (1.29-3.35). Unfavorable sleep is associated with activation of low-grade systemic inflammation.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (2 results)

All 2014 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results)

  • [Journal Article] Overall sleep status and high sensitivity C-reactive protein: a prospective study in Japanese factory workers.2014

    • Author(s)
      Nakamura K, Sakurai M, Miura K, Morikawa Y, Nagasawa SY, Ishizaki M, Kido T, Naruse Y, Nakashima M, Nogawa K, Suwazono Y, Nakagawa H.
    • Journal Title

      Journal of Sleep Research

      Volume: 未定

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overall sleep status and high sensitivity C-reactive protein : a prospective study in Japanese factory workers

    • Author(s)
      Nakamura K, Sakurai M, Miura K, Morikawa Y, Nagasawa SY, Ishizaki M, Kido T, Naruse Y, Nakashima M, Nogawa K, Suwazono Y, Nakagawa H
    • Journal Title

      Journal of Sleep Research

      Volume: (in press)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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