A longitudinal study on the relation between overall sleep status and subsequent changes in serum high-sensitivity C-reactive protein

• Project/Area Number: 23590817
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Kanazawa Medical University
• Principal Investigator: NAKAMURA Koshi 金沢医科大学, 医学部, 准教授 (80422898)
• Co-Investigator(Kenkyū-buntansha): NAKAGAWA Hideaki 金沢医科大学, 医学部, 教授 (00097437)
• Co-Investigator(Renkei-kenkyūsha): MORIKAWA Yuko 金沢医科大学, 看護学部, 教授 (20210156) ; SAKURAI Masaru 金沢医科大学, 医学部, 准教授 (90397216)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 睡眠 / 炎症 / 縦断研究 / 高感度C-反応性蛋白 / 追跡調査

Research Abstract

We investigated the relation between overall sleep status based on the global score of a partially-modified version of Pittsburgh Sleep Quality Index (PSQI) and subsequent changes in serum high-sensitivity C-reactive protein (hsCRP) in 991 middle-aged Japanese factory workers without increased and potentially pathogenic levels of inflammation (hsCRP at year 3 >= 1.0 mg/L). The subsequent changes in hsCRP after 3 years were grater in subjects with unfavorable sleep habits, defined as a PSQI global score > 5.5 points, compared with those with a normal pattern. The geometric means of hsCRP at year 3 were 0.275 mg/L and 0.242 mg/L, respectively, after adjusting for baseline hsCRP and other potential confounders (p=0.04). The multivariate-adjusted odds ratio for developing that inflammation due to unfavorable sleep was 2.08 (1.29-3.35). Unfavorable sleep is associated with activation of low-grade systemic inflammation.

Research Products

• [Journal Article] Overall sleep status and high sensitivity C-reactive protein: a prospective study in Japanese factory workers. (2014)
  • Author(s): Nakamura K, Sakurai M, Miura K, Morikawa Y, Nagasawa SY, Ishizaki M, Kido T, Naruse Y, Nakashima M, Nogawa K, Suwazono Y, Nakagawa H.
  • Journal Title: Journal of Sleep Research Volume: 未定
  • Peer Reviewed
• [Journal Article] Overall sleep status and high sensitivity C-reactive protein : a prospective study in Japanese factory workers
  • Author(s): Nakamura K, Sakurai M, Miura K, Morikawa Y, Nagasawa SY, Ishizaki M, Kido T, Naruse Y, Nakashima M, Nogawa K, Suwazono Y, Nakagawa H
  • Journal Title: Journal of Sleep Research Volume: (in press)
  • Peer Reviewed